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Potassium iodide and preparation method and application thereof

A technology of potassium iodide and reaction, which is applied in the field of medicine, can solve problems such as strict operation requirements, high risk, and complicated process, and achieve the effects of good safety, reduced raw material costs, and simple process

Pending Publication Date: 2021-06-25
合肥市未来药物开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method requires the use of hydrogen, which is highly dangerous and requires strict operation
3) Sulfide method: first, potassium sulfide is reacted with barium sulfide to generate potassium sulfide, and then potassium iodide and sulfur are produced by the reaction of potassium sulfide and iodine. The process is complex; in addition, due to the sulfur content in the potassium iodide product, its application in the fields of food and medicine is limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Add purified water into a 1000mL reaction flask, under stirring, add 150g iron powder (1.35eq.), heat up to 50°C; add 500g iodine (1.0eq.) in total in 12 batches, after the addition is complete, keep the temperature for 6h , filtered to obtain the first product.

[0028] (2) Add 1000mL of purified water to a 5000mL reaction flask, stir, add 394g of potassium bicarbonate (2.0eq.), and raise the temperature to 80°C; slowly add the initial product dropwise, after the addition is complete, keep the reaction for 3h; filter with filter paper first , and then filtered through a 0.45 μm membrane; the filtrate was concentrated to dryness, and 1000 mL of absolute ethanol was added to bring water to the azeotrope. After the water removal was completed, 2500 mL of absolute ethanol was added, stirred for 2 hours, and filtered with suction to obtain white crystals.

[0029] (3) Add 2000mL of purified water to the reaction flask, under stirring, add the crude potassium iodide, dis...

Embodiment 2

[0031] (1) Add purified water into a 1000mL reaction flask, stir, add 165g iron powder (1.5eq.), heat up to 55°C; add 500g iodine (1.0eq.) in total in 12 batches, after the addition is complete, keep the temperature for 6h , Filtration, initial product.

[0032] (2) Add 1000mL of purified water to a 5000mL reaction flask, stir, add 394g of potassium bicarbonate (2.0eq.), and heat up to 90°C; slowly add the initial product dropwise, after the addition is complete, keep the reaction for 3h; first filter with filter paper , and then filtered through a 0.45 μm membrane; the filtrate was concentrated to dryness, and 1000mL of absolute ethanol was added to concentrate and azeotroped with water.

[0033] (3) Add 2000mL of purified water to the reaction flask, under stirring, add the crude potassium iodide, dissolve completely, and filter through a 0.45μm membrane; Afterwards, 3000 mL of absolute ethanol was added, stirred for 2 h, and suction filtered to obtain 562.5 g of white crys...

Embodiment 3

[0035] (1) Add purified water into a 1000mL reaction flask, under stirring, add 150g of iron powder (1.35eq.), and heat up to 65°C; add 500g of iodine (1.0eq.) in 12 batches. After the addition is complete, keep the temperature for 4 hours , filtered to obtain the first product.

[0036] (2) Add 1000mL of purified water to a 5000mL reaction flask, under stirring, add 492.8g of potassium bicarbonate (2.5eq.), and raise the temperature to 95°C; slowly add the initial product dropwise, after the dropwise addition, keep warm for 2 hours; filter paper first Filter, and then filter with a 0.45 μm membrane; concentrate the filtrate to dryness, add 1000mL of absolute ethanol, concentrate and azeotrope with water, after the completion of water addition, add 2500mL of absolute ethanol, stir for 2 hours, and suction filter to obtain white crystals.

[0037](3) Add 2000mL of purified water to the reaction flask, under stirring, add the crude potassium iodide, dissolve completely, and filt...

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PUM

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to potassium iodide and a preparation method and application thereof. The preparation method of the potassium iodide comprises the following steps: (1) adding iron powder into purified water, heating, adding iodine in batches, and carrying out heat preservation reaction to prepare a head product; and (2) dissolving potassium bicarbonate in purified water, heating, dropwise adding the initial product into the solution, carrying out a heat preservation reaction, filtering, crystallizing and purifying to obtain potassium iodide. The method is simple and convenient in process, simple in post-treatment, good in safety and high in product yield, the content of iodate impurities in potassium iodide can be remarkably reduced, and the requirement of large-scale production of potassium iodide can be met.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to potassium iodide and its preparation method and application. Background technique [0002] Trace elements refer to some elements that account for less than 0.01% of the total amount of the body and are necessary for the body, including zinc, copper, manganese, selenium, fluorine, iodine, molybdenum, iron and chromium. Healthy people can obtain sufficient trace elements by consuming a balanced diet. Clinically, due to factors such as disease and age, a considerable number of patients have significant weight loss and / or reduced food intake upon admission. Fasting, surgical trauma, intraoperative hypothermia, pain, Anxiety and other factors lead to an increased risk of malnutrition during surgery. Patients with surgery, trauma, and burns have reduced intake of trace elements due to restricted appetite or limited intake capacity. At the same time, patients are in a hig...

Claims

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Application Information

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IPC IPC(8): C01D3/12A61K33/34A61K33/18A61K9/08A61P3/02A61K33/30A61K33/32A61K33/16A61K33/04A61K33/24A61K33/26
CPCC01D3/12A61K33/30A61K33/34A61K33/32A61K33/16A61K33/04A61K33/18A61K33/24A61K33/26A61K9/08A61K9/0019A61P3/02C01P2006/80C01P2006/60A61K2300/00
Inventor 赵立军徐国义彭松肖垒金秋
Owner 合肥市未来药物开发有限公司
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