Potassium iodide and preparation method and application thereof
A technology of potassium iodide and reaction, which is applied in the field of medicine, can solve problems such as strict operation requirements, high risk, and complicated process, and achieve the effects of good safety, reduced raw material costs, and simple process
Examples
Embodiment 1
[0027] (1) Add purified water into a 1000mL reaction flask, under stirring, add 150g iron powder (1.35eq.), heat up to 50°C; add 500g iodine (1.0eq.) in total in 12 batches, after the addition is complete, keep the temperature for 6h , filtered to obtain the first product.
[0028] (2) Add 1000mL of purified water to a 5000mL reaction flask, stir, add 394g of potassium bicarbonate (2.0eq.), and raise the temperature to 80°C; slowly add the initial product dropwise, after the addition is complete, keep the reaction for 3h; filter with filter paper first , and then filtered through a 0.45 μm membrane; the filtrate was concentrated to dryness, and 1000 mL of absolute ethanol was added to bring water to the azeotrope. After the water removal was completed, 2500 mL of absolute ethanol was added, stirred for 2 hours, and filtered with suction to obtain white crystals.
[0029] (3) Add 2000mL of purified water to the reaction flask, under stirring, add the crude potassium iodide, dis...
Embodiment 2
[0031] (1) Add purified water into a 1000mL reaction flask, stir, add 165g iron powder (1.5eq.), heat up to 55°C; add 500g iodine (1.0eq.) in total in 12 batches, after the addition is complete, keep the temperature for 6h , Filtration, initial product.
[0032] (2) Add 1000mL of purified water to a 5000mL reaction flask, stir, add 394g of potassium bicarbonate (2.0eq.), and heat up to 90°C; slowly add the initial product dropwise, after the addition is complete, keep the reaction for 3h; first filter with filter paper , and then filtered through a 0.45 μm membrane; the filtrate was concentrated to dryness, and 1000mL of absolute ethanol was added to concentrate and azeotroped with water.
[0033] (3) Add 2000mL of purified water to the reaction flask, under stirring, add the crude potassium iodide, dissolve completely, and filter through a 0.45μm membrane; Afterwards, 3000 mL of absolute ethanol was added, stirred for 2 h, and suction filtered to obtain 562.5 g of white crys...
Embodiment 3
[0035] (1) Add purified water into a 1000mL reaction flask, under stirring, add 150g of iron powder (1.35eq.), and heat up to 65°C; add 500g of iodine (1.0eq.) in 12 batches. After the addition is complete, keep the temperature for 4 hours , filtered to obtain the first product.
[0036] (2) Add 1000mL of purified water to a 5000mL reaction flask, under stirring, add 492.8g of potassium bicarbonate (2.5eq.), and raise the temperature to 95°C; slowly add the initial product dropwise, after the dropwise addition, keep warm for 2 hours; filter paper first Filter, and then filter with a 0.45 μm membrane; concentrate the filtrate to dryness, add 1000mL of absolute ethanol, concentrate and azeotrope with water, after the completion of water addition, add 2500mL of absolute ethanol, stir for 2 hours, and suction filter to obtain white crystals.
[0037](3) Add 2000mL of purified water to the reaction flask, under stirring, add the crude potassium iodide, dissolve completely, and filt...
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Description
Claims
Application Information
- IPC
- C01D3/12; A61K33/34; A61K33/18; A61K9/08; A61P3/02; A61K33/30; A61K33/32; A61K33/16; A61K33/04; A61K33/24; A61K33/26
- CPC
- C01D3/12; A61K33/30; A61K33/34; A61K33/32; A61K33/16; A61K33/04; A61K33/18; A61K33/24
- Inventors
- 赵立军; 徐国义