Novel guanidine-containing high-strength antibacterial glass cement composite material for departments of stomatology

Abstract

The invention discloses a novel guanidine-containing high-strength antibacterial glass cement composite material for departments of stomatology. The composite material takes traditional glass-ionomer cement powder, a mechanically enhanced nanomaterial and a guanidine-containing antibacterial agent commonly used in oral clinic as raw materials; a mechanical grinding / ultrasonic blending method is used to uniformly mix the above three raw materials; and therefore a novel dental material glass-ionomer cement and guanidine-containing antibacterial agent mixed powder can be obtianed. The composite material is simple in preparation method, simple in equipment, low in cost and easy in large-scale promotion. All the physical properties of the prepared novel dental material accord with national pharmaceutical industry standards; the novel dental material has extremely high antibacterial property and extremely low cytotoxicity; and therefore, cariogenic bacteria residues after filling can be greatly reduced, the success rate of filling treatment can be increased, and the clinical application scope of the glass-ionomer cement can be extended.

Description

technical field [0001] The invention belongs to the technical field of medical polymers, and relates to a novel high-strength antibacterial glass cement composite material containing guanidine in stomatology. Background technique [0002] Glass ionomer cement is a new type of dental restoration material, which is widely used in the restoration of tooth neck defects, pit and fissure sealing, and restoration of deciduous teeth. Glass ionomer cement can effectively bond with dental hard tissues such as enamel and dentin. Glass ionomers release fluoride ions (F) to replace the hydroxyl groups of hydroxyapatite in dental tissue, forming a more stable fluorapatite structure. Inhibits demineralization of dental tissue and promotes remineralization. However, the clinical system evaluation results show that the fluoride release of traditional glass cement is insufficient, and the released fluoride is not enough to inhibit bacteria and resist bacterial invasion. The residual bacteria...

AI Technical Summary

Problems solved by technology

[0003] In recent years, the antibacterial properties of glass cements are mainly improved by the composite application of fluoride or antibacterial agents and glass cements. However, the common glass cement modified materials still have defects in terms of antibacterial properties and cytotoxicity: 1) Fluorine Compounds: For example, the Chinese invention patent CN108245433 modifies glass cement by composite fluorinated graphene (FG), which improves the fluorine release and mechanical properties

However, the two-dimensional material FG is prone to agglomeration, and too much FG seriously affects the normal curing of glass cement when the added content reaches 4wt%. 2) Quaternary ammonium salts: Quaternary ammonium salts have excellent antibacterial effect, but Ammonium salts have a killing effect on eukaryotic cells, and the modified glass cement group exhibits certain cytotoxicity when the mass fraction reaches a certain level; 3) Chitosan (CS): chitosan can significantly improve the antibacterial performance of glass cement, However, the combination of glass cement material and CS often results in a low pH value of the surrounding environment, which shows obvious cytotoxicity when the extraction liquid fraction is greater than 0.50; 4) antibiotics: antibiotics have a strong antibacterial effect, but due to a large amount of abuse, 5) Chlorhexidines (CHX): constructing chlorhexidine nanoparticles is a feasible way to prepare anti-caries GIC, but chlorhexidine has toxic effects on human fibroblasts. Cytotoxicity, long-term exposure can cause dental pain, taste disturbance and other adverse reactions

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