Modified macroporous adsorption resin, and preparation method and application thereof

An adsorption resin and pore adsorption technology, which is applied in separation methods, chemical instruments and methods, solid adsorbent liquid separation, etc., can solve the problem of affecting the macroporous adsorption resin pore structure parameters of the matrix and the uncontrollable thickness of the grafted polymer graft layer , difficult to control the reaction process, etc., to achieve the effect of hydrophilic or functional modification, easy control of the process, and increased compatibility

CN113231046AActive Publication Date: 2021-08-10GUANGZHOU KONCEN BIOSCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2021-08-10

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Abstract

The invention relates to a modified macroporous adsorption resin, and a preparation method and application thereof. The preparation method of the modified macroporous adsorption resin comprises the following steps: obtaining macroporous adsorption resin, wherein the surface of the macroporous adsorption resin contains double bonds; and mixing water, an oxidizing agent and the macroporous adsorption resin, and carrying out one-step oxidation reaction to oxidize the double bonds into hydroxyl groups, wherein the oxidizing agent is a combination of sulfuric acid and peracetic acid, or pypocholoride, periodate, or a combination of hydrogen peroxide and peracetic acid, the pypocholoride is at least one of sodium hypochlorite, potassium hypochlorite and calcium hypochlorite, and the periodate is at least one of sodium periodate and potassium periodate. According to the preparation method of the modified macroporous adsorption resin, hydrophilic modification of the macroporous adsorption resin can be achieved through one-step reaction, no organic solvent is needed, and the preparation method is environmentally friendly, few in reaction by-products, easy to clean and high in safety to human bodies.
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Description

technical field

[0001] The invention relates to polymer materials, in particular to a modified macroporous adsorption resin and its preparation method and application. Background technique

[0002] As early as 1974, macroporous adsorbent resin was used to adsorb barbiturate and glutamine in blood (see patent document US3794584A). This type of resin is generally synthesized with a high content (>50%) of divinylbenzene as a crosslinking agent, and the specific surface area of ​​the finished product is generally 500-800m 2 / g, on this basis, further by using chloromethyl ether reagents to carry out the Fridel-Crafts (Fridel-Crafts) reaction for secondary cross-linking, the specific surface can be greatly improved, even up to 1000m 2 / g or more (see literature "Wang Jiaxing et al., Preparation and Application of Biochemical Separation Media, Chemical Industry Press, Beijing, P84"). However, since the skeleton structure of the macroporous adsorption resin is prepared by free...

Examples

preparation example Construction

[0045] The present invention provides a kind of preparation method of modified macroporous adsorption resin, comprising the following steps:

[0046] Obtaining a macroporous adsorbent resin, the surface of which contains double bonds;

[0047] Mix (solvent) water, oxidizing agent and macroporous adsorption resin to carry out one-step oxidation reaction to oxidize the double bond to hydroxyl.

[0048] It can be understood that the one-step oxidation reaction means that the double bonds contained on the surface of the macroporous adsorption resin can be oxidized to hydroxyl groups through a one-step reaction without other intermediate treatment processes or intermediate products. Corresponding to the traditional method, the one-step oxidation reaction refers to the process without going through the epoxy intermediate product.

[0049] In one specific example, the one-step oxidation reaction does not involve other solvents except water. Furthermore, the one-step oxidation reactio...

Embodiment 1

[0088] This embodiment provides a preparation method of a modified macroporous adsorption resin, using sulfuric acid and peracetic acid as oxidants, the steps are as follows:

[0089] (1) Get 10 g of macroporous adsorption resin, add 50 mL of aqueous solution containing 2% sulfuric acid and 2% peracetic acid, and react the resulting reaction solution for 6 hours at a temperature of 20° C. and a stirring speed of 180 rpm;

[0090] (2) After the reaction is completed, the obtained macroporous adsorption resin is cleaned with absolute ethanol and purified water;

[0091] (3) Add 5 times the volume of 1M sodium hydroxide aqueous solution to the washed macroporous adsorbent resin for washing, and then wash with purified water until neutral to obtain a modified macroporous adsorbent resin.

Embodiment 2

[0093] This embodiment provides a method for preparing a modified macroporous adsorption resin, using sodium hypochlorite as an oxidizing agent, and the steps are as follows:

[0094] (1) Take 10 g of macroporous adsorption resin, add 50 mL of 1% sodium hypochlorite aqueous solution, and react the resulting reaction solution for 6 hours at a temperature of 20° C. and a stirring speed of 180 rpm;

[0095] (2) After the reaction is completed, the obtained macroporous adsorption resin is cleaned with absolute ethanol and purified water;

[0096] (3) Add 5 times the volume of 1M sodium hydroxide aqueous solution to the washed macroporous adsorbent resin for washing, and then wash with purified water until neutral to obtain a modified macroporous adsorbent resin.