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Magnesium-based metal microtubule for medical implantation and preparation method thereof

A magnesium-based metal and microtube technology, applied in the fields of cardiovascular and cerebrovascular repair and implant materials antibacterial, nerve repair implants, can solve the problems of unsatisfactory biological activity and poor biological activity, and achieve good biocompatibility , improve the success rate, reduce the effect of infection

Active Publication Date: 2021-08-10
SHENYANG LIGONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The biosafety and biocompatibility of traditional metal biomaterials are not satisfactory, but their bioactivity is poor
Although people have carried out a variety of surface modification works on traditional metal biomaterials, their biological activity is still not ideal

Method used

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  • Magnesium-based metal microtubule for medical implantation and preparation method thereof
  • Magnesium-based metal microtubule for medical implantation and preparation method thereof
  • Magnesium-based metal microtubule for medical implantation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Put the bismuth rod into the furnace body of the deposition chamber, the length of the bismuth rod is 8cm, and the diameter is 2.5mm. The magnesium raw material is placed in an evaporation chamber, and the chemical composition of the magnesium raw material is as follows: Cu content is 0.2%, Zn content is 1%, and the balance is Mg.

[0027] Example 1 uses coating deposition technology to uniformly deposit magnesium-based metal on the surface of bismuth rods, and then removes the bismuth rods by melting to obtain magnesium-based metal microtubes. The specific preparation steps are as follows: (1) the rod substrate Ultrasonic cleaning with anhydrous ethanol and deionized water in sequence, dried with dry nitrogen, placed on the rotating sample stage, and sent to the deposition chamber; (2) Put the magnesium alloy particles into the target position of the evaporation chamber, and pump the ultimate vacuum to 10 -4 Pa, and then filled with high-purity argon gas, and then evac...

Embodiment 2

[0029] Put the indium rod into the furnace body of the deposition chamber, the length of the indium rod is 10 cm, and the diameter is 2.5 mm. The magnesium raw material is placed in the evaporation chamber. The chemical composition of the magnesium raw material is as follows: Cu content is 0.4%, Zn content is 2%, Sr content is 2%, and the balance is Mg. Set the sublimation temperature of the magnesium alloy to 450°C and the working pressure to 1×10 -2 Pa, the deposition temperature is 200°C, and the deposition time is 60 minutes. The sample is taken out after cooling with the furnace. -4 The indium rod was melted and removed by heating to 200°C under Pa vacuum to obtain a magnesium tube with a wall thickness of 200 µm and a tube degradation time of 2 weeks. The surface electron microscope characterization and elemental analysis results of the magnesium alloy microtubes are shown as follows: figure 2 shown. The tensile strength of the pipe is 190Mpa and the elongation is 10...

Embodiment 3

[0031] Put the tin rod into the furnace body of the deposition chamber, the length of the tin rod is 10cm, and the diameter is 3mm. The magnesium raw material is placed in the evaporation chamber. The chemical composition of the magnesium raw material is as follows: Cu content is 0.5%, Zn content is 3%, Sr content is 2%, and the balance is Mg. Set the sublimation temperature of the magnesium alloy to 450°C and the working pressure to 1×10 -2 Pa, the deposition temperature is 200°C, and the deposition time is 60 minutes. The sample is taken out after cooling with the furnace. -4 The indium rod was melted and removed by heating to 200°C under Pa vacuum to obtain a magnesium tube with a wall thickness of 200 µm and a tube degradation time of 2 weeks. The pipe is soaked in SBF, and its pH value change curve is as follows image 3 shown. The tensile strength of the pipe is 180Mpa and the elongation is 11%.

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Abstract

The invention belongs to the technical field of implant materials, and particularly relates to a magnesium alloy microtubule for medical implantation and a preparation method thereof.A magnesium-based metal coating is evenly prepared on the surface of a bar through a coating deposition technology, then a bar base body is removed through a melting method, and therefore, the magnesium-based metal microtubule is obtained. The microtubule is characterized in that the tube diameter thereof is 1-5mm, the thickness of the tube wall is 50-500[mu]m, and the base body is made of any one of low-melting-point metal bismuth, indium and tin or a quartz glass tube. Compared with the prior art, the magnesium alloy microtube has the beneficial effects that 1) the requirements of different implantation parts on mechanical properties and structures are met, 2) the magnesium alloy ,microtube has good biocompatibility, an alkaline environment generated by degradation of magnesium in vivo is utilized to provide an antibacterial function, and magnesium ions generated by degradation and beneficial alloy elements promote cell proliferation, so that repair of blood vessels and nerves is promoted; 3) the problem of difficulty in traditional plastic processing of the magnesium-based metal microtube is avoided, and 4) different sizes of magnesium-based metal microtubes can be manufactured, and the degradation speed is controllable.

Description

technical field [0001] The invention belongs to the technical field of nerve repair implants, cardiovascular and cerebrovascular repairs, and antibacterial implant materials, and in particular relates to a magnesium-based metal microtube for medical implantation and a preparation method thereof. Background technique [0002] Peripheral nerve injury caused by trauma, nerve degeneration, ischemia and hypoxia has become one of the common clinical diseases. Once the nerve is broken and damaged, the nerve signal transmission pathway will be interrupted, the corresponding organ function will be affected, and the body function will be impaired, which will seriously affect people's quality of life. In addition, the ability of neurons to regenerate is weak and the nervous system is difficult to remodel. Once nerve damage occurs, it is difficult to recover. Therefore, the repair of damaged nerves has always been a hot and difficult point in the medical field. At present, autologous ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C14/24C23C14/16C23C14/18C22C23/04C22C23/00A61L27/58A61L27/54A61L27/50A61L27/04
CPCC23C14/24C23C14/16C23C14/18C22C23/04C22C23/00A61L27/047A61L27/50A61L27/54A61L27/58A61L2430/32A61L2300/412A61L2300/404A61L2300/102
Inventor 于晓明由雪儿
Owner SHENYANG LIGONG UNIV
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