Vibrio parahaemolyticus lytic bacteriophage vB_VpP_DE17 and application thereof

A hemolytic vibrio and phage technology, applied in the direction of phage, virus/phage, and medical raw materials derived from virus/phage, can solve threats, irreversible damage to the native microbial ecosystem, antibiotic residues, human health, etc.
CN113337474AActive Publication Date: 2021-09-03SOUTH CHINA AGRI UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTH CHINA AGRI UNIV
Publication Date
2021-09-03

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Abstract

The invention discloses a vibrio parahaemolyticus bacteriophage vB_VpP_DE17, which has a strong lysis effect on vibrio parahaemolyticus and can infect 10 vibrio parahaemolyticus in 11 O antigens. The bacteriophage can be amplified through a specific host to generate a fermentation product with high titer, and can tolerate the high temperature of 60 DEG C and tolerate pH of 5.0-10.0. The optimal multiplicity of infection (MOI) of the vibrio parahaemolyticus bacteriophage is wide, and the vibrio parahaemolyticus bacteriophage has a strong effect of preventing and controlling the vibrio parahaemolyticus when the MOI is in a range of 1-0.1. Therefore, the vibrio parahaemolyticus bacteriophage can be used for preventing and controlling acute hepatopancreas necrosis syndrome caused by vibrio parahaemolyticus in the aquaculture process, and has high application value.
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Description

technical field

[0001] The invention relates to the field of disease prevention and treatment, in particular to Vibrio parahaemolyticus lytic phage and application thereof. Background technique

[0002] Vibrio parahaemolyticus (Vibrio parahaemolyticus) is a halophilic Gram-negative bacterium belonging to the Vibrio family and the genus Vibrio, and is a zoonotic pathogen. After a person is infected by parahemolytic, the main symptoms are diarrhea, fever, gastroenteritis, etc., which can be fatal in severe cases. Vibrio parahaemolyticus is mainly widely distributed in seawater and aquatic products such as fish, shrimp, crab, and shellfish. It is also a pathogen that needs to be controlled and controlled in most aquaculture processes.

[0003] From the beginning of the 20th century to the present, antibiotics are still used to prevent and control Vibrio parahaemolyticus in the process of aquaculture, and the long-term use and abuse of antibiotics have led to the continuous inc...

Claims

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