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Composition with effects of reinforcing barrier, resisting allergy and preserving moisture as well as preparation method and application of composition

A composition and barrier technology, applied in the direction of medical preparations containing active ingredients, drug combinations, cosmetic preparations, etc., can solve complex skin problems, frequent allergic symptoms, etc., to prevent re-aggregation and reduce sensitization , high affinity effect

Active Publication Date: 2021-10-22
COSMAX CHINA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most of the anti-sensitivity raw materials on the market are repairing and soothing after sensitive skin. However, due to external factors such as sunlight, pollution, and excessive use of cosmetics, modern people have skin problems Complex, frequent sensitive symptoms

Method used

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  • Composition with effects of reinforcing barrier, resisting allergy and preserving moisture as well as preparation method and application of composition
  • Composition with effects of reinforcing barrier, resisting allergy and preserving moisture as well as preparation method and application of composition
  • Composition with effects of reinforcing barrier, resisting allergy and preserving moisture as well as preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0047] The preparation method is as follows:

[0048] (1) Colostrum preparation: select fresh colostrum, filter to remove impurities, centrifugally degrease, 0.22 μm pore size ceramic membrane cross-flow filtration technology microfiltration to sterilize, collect the filtrate after high-pressure homogenization, add deionized water 20 times, mix well, That is the diluted colostrum. The centrifugation conditions are 3000-5000r / min, 10-30min, below 40°C, and the filtration temperature is below 45°C.

[0049] (2) Preparation of keratin: clean and dry the wool fibers, shred them and add hydrogen peroxide for oxidation pretreatment. The oxidation pretreatment time is 30-40min. Add keratinase to carry out enzymolysis reaction for 100-120min, the amount of keratinase added is 3-5% of the substrate, and the reaction temperature is 60°C. Warm to inactivate the enzyme, the enzymolysis solution is cooled to room temperature and centrifuged, the supernatant is taken, and dried at low tem...

experiment example 1

[0058] Cytotoxicity test:

[0059] MTT assay is an experimental method widely used in the detection of cytotoxicity or cell proliferation by measuring the number of living cells. The detection principle is that succinate dehydrogenase in the mitochondria of living cells can make the water-soluble yellow salt MTT (3- (4,5-dimethylthiazole-2)-2,5-diphenyltetrazolium bromide) is reduced to water-insoluble blue formazan and deposited in cells, while dead cells have no such function. The generated crystalline formazan is generally added to DMSO (dimethyl sulfoxide), and the absorbance is measured after dissolution. The specific experimental method is in a 96-well plate according to 1X10 4 Inoculate 100 μl of DMEM medium containing 10% bovine serum and 100 μl of keratinocytes (HaCaT) at a density of one per well, and replace with serum-free medium after 24 hours of culture. Different concentrations of the composition were added to the serum-free medium for treatment and cultured f...

experiment example 2

[0066] Antisensitivity test:

[0067] Hyaluronidase is a participant in allergic reactions. Studies have shown that hyaluronidase has a strong correlation with inflammation and allergy. Many antiallergic drugs have a strong inhibitory effect on hyaluronidase activity. In vitro hyaluronidase inhibition method uses the hyaluronidase inhibition rate as an index, which can evaluate the anti-sensitivity ability.

[0068] Take 0.1mL of 0.25mmol / L CaCl2 solution and 0.5mL hyaluronidase solution and incubate at 37°C for 20min; add Examples 1-12 and Comparative Examples 1-3, 0.5mL each, and continue to incubate at 37°C for 20min; Add 0.5mL sodium hyaluronate solution at 37°C for 30min, and place it at room temperature for 5min; add 0.1mL of 0.4mol / L NaOH solution and 0.5mL acetylacetone solution, heat in a boiling water bath for 15min, then immediately cool with ice water for 5min; Add 1.0 mL of Ehrlich reagent and dilute with 3.0 mL of absolute ethanol, let stand for 20 min to develo...

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Abstract

The invention discloses a composition with effects of reinforcing a barrier, resisting allergy and preserving moisture as well as a preparation method and an application of the composition. The composition is prepared from the following components: diluted colostrum, keratin and deep sea fish oil in a mass ratio of (5-15): (1-2): (0.05-0.2). The composition with the barrier strengthening, anti-allergy and moisturizing effects has the advantages of being good in affinity with skin and hair, mild and low in irritation. The composition can strengthen the barrier function and improve the skin protection, has the effects of preserving moisture, nourishing, resisting inflammation, relieving allergy, resisting oxidation, smoothing wrinkles and the like, and can prevent and improve the sensitive symptom of the skin.

Description

technical field [0001] The invention belongs to the field of cosmetics, and in particular relates to a composition with barrier-strengthening, anti-allergic and moisturizing effects, a preparation method and application thereof. Background technique [0002] With the rapid development of society and the acceleration of industrialization, the living environment of human beings is also changing rapidly. The external environment faced by the skin is becoming more and more complicated, and the self-regulation level of the skin is disordered, especially on the face, there will be some skin sensations such as dryness, itching, burning, tingling, and tightness. Feeling of discomfort, thinking that I have sensitive skin or sensitive skin. [0003] Sensitive skin (Sensitive Skin, SS) specifically refers to a hyperresponsive state of the skin under physiological or pathological conditions, which mainly occurs on the face. Subjective symptoms such as itching, tightness, etc., with or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/98A61K8/92A61K8/65A61P37/08A61Q19/00
CPCA61K8/986A61K8/65A61K8/92A61K8/987A61Q19/00A61P37/08A61K2800/782A61K2800/5922A61K2800/805Y02P20/54
Inventor 周春亚周秋娜金荣熙申彦晟金延埈
Owner COSMAX CHINA INC
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