High-elasticity and high-drug-loading-capacity embolization microsphere and preparation method thereof

Abstract

The invention discloses a high-elasticity and high-drug-loading-capacity embolization microsphere and a preparation method thereof, and relates to the field of medical polymer materials. The embolization microsphere is prepared by random copolymerization of polyvinyl alcohol macromolecules as a parent, a ring-forming grafting agent, a double-bond-containing micromolecule bridging agent and an ionic crosslinking agent, the structure is a network structure which takes a micromolecule cross-linking body for stretching and vibration and the polyvinyl alcohol macromolecules as a skeleton, the variable elasticity is high, the drug loading capacity is high, the drug slow-control release time is long, the particle size distribution is uniform, the microsphere and the blood vessels are perfectly matched, the embolization is more thorough, meanwhile, chemotherapy drugs are slowly released to avoid sudden release of the drugs, the medicine concentration in a tumor area can be maintained at a relatively high level for a long time, the medicine concentration in systemic circulation is reduced, and the treatment effect is improved.

Description

technical field [0001] The invention relates to the field of medical polymer materials, in particular to an embolic microsphere with high elasticity and high drug loading and a preparation method thereof. Background technique [0002] Liver cancer is one of the 10 most common tumors in the world, and China is the country with the highest incidence of primary liver cancer, accounting for more than 50% of the global patients. The treatment methods for primary liver cancer include surgical resection, liver transplantation, microwave ablation, transarterial chemoembolization (TACE), radiotherapy and other treatment options. Clinical practice and research have shown that transhepatic arterial embolization is the first choice and the most effective treatment option for patients with unresectable middle and advanced liver cancer, which can lead to longer survival and has significant clinical effects. [0003] At present, the mechanism of TACE is mainly to superselectively embolize...

AI Technical Summary

Problems solved by technology

The specific defects and deficiencies are as follows: (1) For example, sodium alginate microspheres have poor elasticity due to ion cross-linking polymerization, and cannot be compressed and repaired arbitrarily. After the microspheres are transported through the catheter, the microspheres are prone to crushing, resulting There is a risk of embolism drifting, and at the same time, the vascular embolism is not tight; (2) for example, chitosan microspheres have a certain degradation ability, but their mechanical properties are poor, and they cannot withstand the impact of blood flow, which limits their clinical application; (3) and At present, there are polyvinyl alcohol embolic microspheres on the market, which are not biodegradable. As the drug-loadable polyvinyl alcohol embolic microspheres, polyvinyl alcohol needs to be modified and derivatized, and more toxicological substances are introduced, resulting in The process is complicated. Secondly, the drug loading of polyvinyl alcohol embolization microspheres is still relatively low, and it releases chemotherapy drugs in blood vessels quickly, which makes the drug stay in the target tumor tissue for a short time and affects the therapeutic effect.

At the same time, the particle size range of microspheres (100-300um, 300-500um) is widely distributed, and the particle size is not uniform. The size of the microspheres cannot be precisely regulated, and the target blood vessels cannot be completely embolized, and superselective treatment cannot be achieved.

These factors greatly reduce the clinical efficacy of drug-loaded microsphere embolization agents

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