Preparation method of responsive drug carrier for spinal cord injury repair

A technology of spinal cord injury and responsiveness, which is applied in the field of preparation of responsive drug carriers, can solve the problems of difficulty in achieving specific drug release at the injury site, simplicity, etc., and achieve the effects of increasing loading capacity, improving therapeutic effect, and avoiding burst release

Active Publication Date: 2022-05-03
WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite great progress, existing biomaterials for the treatment of spinal cord injury are still relatively simple in structure, making it difficult to achieve injury-site-specific drug release

Method used

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  • Preparation method of responsive drug carrier for spinal cord injury repair
  • Preparation method of responsive drug carrier for spinal cord injury repair
  • Preparation method of responsive drug carrier for spinal cord injury repair

Examples

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Embodiment Construction

[0035] The invention provides a method for preparing a responsive drug carrier for spinal cord injury repair, such as figure 1 As shown, it specifically includes the following steps:

[0036] S1. Preparation of Stretched Inverse Opal Membrane

[0037] Disperse silica nanoparticles with a diameter of 300nm in an ethanol solution to form a 2% w / v monodisperse silica nanoparticle ethanol solution, pour the monodisperse silica nanoparticle ethanol solution into a beaker, and prepare a clean Insert the glass slide vertically into the ethanol solution of monodisperse silica nanoparticles, then place the beaker in a constant temperature and humidity incubator until the ethanol evaporates and open the incubator, the monodisperse silica nanoparticles The assembly was deposited on a glass slide, which was then calcined in a muffle furnace at 400°C for 2 hours to form an array of closely connected silica colloidal crystals. Prepare the PLGA ethyl acetate solution of 15% w / v, wherein PL...

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Abstract

The invention provides a preparation method of a responsive drug carrier for spinal cord injury repair, which comprises the following steps: S1, depositing monodisperse silicon dioxide nanoparticles on a glass slide, dropwise adding poly (lactic acid-glycolic acid) on the glass slide, and etching the monodisperse silicon dioxide nanoparticles after the poly (lactic acid-glycolic acid) is cured, so as to obtain poly (lactic acid-glycolic acid); a flexible inverse opal film is obtained; s2, dissolving agarose in a phosphoric acid buffer salt solution to form a solution A, dissolving gelatin and hyaluronic acid in the phosphoric acid buffer salt solution to form a solution B, mixing the solution A and the solution B to form a pre-gel solution, then adding fibroblast growth factors 10, chloroquine phosphate and black phosphorus quantum dots into the pre-gel solution, and mixing to form a drug-loaded pre-gel solution; s3, dropwise adding the drug-loaded pre-gel solution prepared in the step S2 into the inverse opal membrane prepared in the step S1, and obtaining the drug-loaded inverse opal membrane after the drug-loaded pre-gel solution is gelatinized.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a preparation method of a responsive drug carrier for spinal cord injury repair. Background technique [0002] Spinal cord injury is a severe neurological trauma that can lead to limb and muscle weakness, impaired motor control and even paralysis. Spinal cord injury is divided into direct mechanical injury and secondary injury. After direct mechanical injury, the blood-spinal cord barrier is destroyed, inflammatory cell chemotactic infiltration, axonal atrophy, neuron apoptosis and other secondary injuries hinder the regeneration and repair of the spinal cord. major factor. In order to effectively repair spinal cord injury, a variety of drugs and treatment methods have been explored, but the treatment effect is not satisfactory and needs to be further improved. Growth factors, such as fibroblast growth factor 10 (FGF10), have been reported to protect neurons, stabi...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/34A61K47/36A61K47/42A61K38/18A61K33/42A61K31/4706A61K41/00A61P25/00
CPCA61K9/7007A61K38/1825A61K31/4706A61K33/42A61K47/34A61K47/36A61K47/42A61P25/00A61K41/0042A61K2300/00Y02A50/30
Inventor 赵远锦邬芬赞肖健邵长敏
Owner WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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