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Preparing method for biological active peptide and titanium alloy hard tissue implanting material

A technology for bioactive and implantable materials, which is applied in the field of preparation of bioactive titanium and titanium alloy hard tissue implant materials, and can solve the problem of high residual stress at the interface between the coating and the substrate, poor bonding strength between the coating and the substrate, and corrosion of implants. Body and other problems, to achieve the effect of preventing the release of harmful metal ions, low cost, and improving wear resistance

Inactive Publication Date: 2004-04-21
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, plasma spraying is often used to prepare hydroxyapatite (HA) coatings in the technology of modifying the surface of titanium and titanium alloys to make them biologically active. Since plasma spraying is carried out at high temperature (12000°C , the HA coating is easy to decompose, the residual stress between the coating and the substrate is high, the bonding strength between the coating and the substrate is poor, the coating is not dense, and the biological fluid can easily penetrate into the substrate, causing interface corrosion and loosening of the implant.
[0004] In December 1999, "Material Development and Application", Volume 14, Issue 6, introduced the preparation methods of various hydroxyapatite bioceramic coatings, and compared the advantages and disadvantages of various methods; in March 2000, "Chinese Oral Implantology Magazine, Volume 5, Issue 1, introduces the research on medical titanium and titanium alloy implants, and summarizes the research progress of titanium and titanium alloy implant materials in recent years from four aspects; and for the present invention through chemical and electrochemical modification Methods to prepare bioactive titanium and titanium alloy implant materials have not been reported yet

Method used

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  • Preparing method for biological active peptide and titanium alloy hard tissue implanting material
  • Preparing method for biological active peptide and titanium alloy hard tissue implanting material
  • Preparing method for biological active peptide and titanium alloy hard tissue implanting material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Adopt method of the present invention to process on Ti6Al4V alloy surface, specifically as follows:

[0029] 1) Ti6Al4V alloy is selected, and the sample size is 25×15×1mm 3 , the sample first passes through 400 # Grinding with water-resistant sandpaper to produce a rough surface, then cleaning it with acetone for 5 times in an ultrasonic cleaner, cleaning it with distilled water, taking it out and blowing it dry;

[0030] 2) The preparation method of the electrolyte is as follows: in 1L of methanol solution (water content less than 1%), add 25g of analytically pure sodium nitrate chemical reagent to prepare the electrolyte, the concentration of the electrolyte is 25g / L, with Ti6Al4V alloy As the anode, the carbon rod is used as the cathode, and the electrolyte is used as the conductive medium to carry out anodic oxidation. 2 , when the oxidation time is 80 minutes, a uniform, dense and thick titanium oxide film is obtained. After the above treatment, the thickness of...

Embodiment 2

[0041] The difference from Example 1: Ti6Al4V alloy is selected, and the sample size is 25×15×1mm 3 , the sample first passes through 400 # Polished with water-resistant sandpaper to produce a rough surface, then cleaned with acetone for 4 times in an ultrasonic cleaner, cleaned with distilled water, and dried after taking it out; the preparation method of the electrolyte is as follows: in 1L of methanol solution (water content less than 1 %), add 10g of analytically pure potassium sulfate chemical reagent, be mixed with electrolytic solution, the concentration of electrolytic solution is 10g / l, with Ti6Al4V alloy as anode, with platinum sheet as negative electrode, with described electrolytic solution as conductive medium, carry out Anodizing, electrolysis parameters: electrolyte temperature is 20°C, current density is 10mA / cm 2 , when the oxidation time was 120min, a uniform, dense and thick titanium oxide film was obtained. After the above treatment, the thickness of the p...

Embodiment 3

[0044] Adopt the inventive method to process on metal Ti surface, specifically as follows:

[0045] 1) Metal Ti is selected, and the sample size is 20×10×1mm 3 , the sample first passes through 400 # Grinding with water-resistant sandpaper to produce a rough surface, then cleaning it with acetone for 3 times in an ultrasonic cleaner, cleaning it with distilled water, taking it out and blowing it dry;

[0046] 2) The preparation method of the electrolyte is as follows: in 1L of methanol solution, add 15g of analytically pure sodium nitrate chemical reagent to prepare the electrolyte, the concentration of the electrolyte is 15g / L, with titanium as the anode and stainless steel as the cathode, Use the electrolyte as the conductive medium for anodic oxidation, electrolysis parameters: the temperature of the electrolyte is 60°C, and the current density is 15mA / cm 2 , when the oxidation time is 90 minutes, a uniform, dense and thick titanium oxide film is obtained. After the above...

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Abstract

A bioactive Ti or Ti alloy used as the hard tissue implantation material is prepared from Ti or Ti alloy through electrochemical treating to generate an oxidized film on surface, chemical treating with alkali solution to generate a porous reticular layer of titanate gel, heat treating to make said gel layer become crystalline, and immersing in human bionic liquid to generate phoshpotite layer. Its advantages are high hardness and binding strength to basic body, and low cost.

Description

technical field [0001] The invention relates to the field of preparation of bioactive implant materials, in particular to a preparation method of bioactive titanium and titanium alloy hard tissue implant materials. Background technique [0002] The advancement of modern science and technology has enabled human beings to transform and create new life forms, and the artificialization of organs has become one of the cutting-edge technologies of today's medical science. Its potential core is the development of medical biomaterials. The development of medical biomaterials will enable people to change the methods of dealing with the loss of function of the human body from tissue removal, tissue replacement, and finally tissue reconstruction. Ti alloys have high strength, low elastic modulus, and The advantages of good corrosion performance have always attracted people's attention in the research and application of artificial implants. However, titanium and titanium alloys are biol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/32C23C28/00C25D11/26
Inventor 熊天英吴杰金花子吴敏杰崔新宇赵颖
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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