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Ginkgoleaf oral cavity disintegrating tablet and its preparation method

A technology of orally disintegrating tablets and ginkgo biloba, which is applied in the field of orally disintegrating tablets, can solve problems such as difficulty in swallowing, heavy economic burden for patients, and bioavailability of the first-pass effect of the liver and intestines, and achieve the goal of solving the difficulty of taking medicine and improving the compliance of taking medicine Effect

Active Publication Date: 2004-12-22
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] Due to reasons such as preparation technology, most oral preparations have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affects the efficacy of the drug and directly affect the outcome of the treatment
In addition, traditional oral preparations require a large amount of water to be taken down, which makes it difficult for many elderly people, infants, or patients with difficulty swallowing and inconvenient water intake.
[0020] Injections are often prone to allergic reactions or adverse reactions [2, 3]. At the same time, injections also have the disadvantages of difficult operation, great pain for patients, high manufacturing and medical costs, and heavy economic burden for patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 Direct taste correction method

[0052] 1. Prescription

[0053] 1. Raw material-40g ginkgo biloba extract;

[0054] 2. Effervescent agent-citric acid 18g; sodium bicarbonate 14g;

[0055] 3. Filling agent-microcrystalline cellulose 20g, mannitol 79g;

[0056] 4. Glidant-micro powder silica gel 4g;

[0057] 5. Disintegrant-cross-linked polyvinylpyrrolidone 16g;

[0058] 6. Flavoring agent-aspartame 8g, mint flavor 0.4g;

[0059] 7. Lubricant-0.6g magnesium stearate;

[0060] The total weight is 200g, and it is made into 1000 tablets, 200mg / tablet, and the ginkgo leaf extract content is 20%.

[0061] 2. Preparation method

[0062] The first step is to take the ginkgo biloba extract, aspartame and peppermint flavor, respectively pass through a 40-mesh sieve, and mix well to obtain the flavored ginkgo biloba extract raw materials for use;

[0063] In the second step, take microcrystalline cellulose, citric acid, sodium bicarbonate, mannitol, micronized silica gel, an...

Embodiment 2

[0065] Example 2 Prefabricated microcapsule taste masking method

[0066] 1. Prescription

[0067] 1. Raw material-40g ginkgo biloba extract;

[0068] 2. Capsule material-gelatin 15g, polyethylene glycol 8g;

[0069] 3. Filling material-mannitol 111.3g;

[0070] 4. Disintegrant-croscarmellose sodium 20g;

[0071] 5. Glidant-micro-powder silica gel 4.4g;

[0072] 6. Flavoring agent-stevioside 4g, ginseng flavor 0.4g;

[0073] 7. Lubricant-0.6g magnesium stearate;

[0074] The total weight is 203.7g, and it is made into 1000 tablets, 203.7mg / tablet, and the ginkgo leaf extract content is 19.6%.

[0075] 2. Preparation method

[0076] The first step is to take gelatin and polyethylene glycol into a solution of a certain concentration with distilled water, then add micro-powdered silica gel and mix it as a capsule material for use;

[0077] The second step is to take the ginkgo biloba extract and suspend it in a vertical airflow, and then perform the air suspension method to prepare m...

Embodiment 3

[0080] Example 3 Powder coating taste masking method

[0081] 1. Prescription

[0082] 1. Raw material-40g ginkgo biloba extract;

[0083] 2. Coating material-ethyl cellulose 12g, Eudragit  E100 8g, Eudragit  NE30D 3.3g;

[0084] 3. Filling agent-mannitol 111.3g;

[0085] 4. Glidant-micro-powder silica gel 4.4g;

[0086] 5. Disintegrant-cross-linked polyvinylpyrrolidone 16g;

[0087] 6. Flavoring agent-aspartame 4g, orange flavor 0.4g;

[0088] 7. Lubricant-0.6g magnesium stearate;

[0089] The total weight is 200g, and it is made into 1000 tablets, 200mg / tablet, and the ginkgo leaf extract content is 20%.

[0090] 2. Preparation method

[0091] The first step is to take ethyl cellulose, Eudragit  E100 and Eudragit  NE30D is dissolved in more than 95% pharmaceutical industrial ethanol and diluted to a certain concentration for use;

[0092] The second step is to take the ginkgo biloba extract and place it in a boiling bed to boil, and spray the above solution at a certain spee...

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PUM

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Abstract

A oral disintegating tablet of gingko leaf for treating coronary heart disease, angina pectoris, acute cerebral infaction and cerebral arte riosclerosis is prepared from the extract of gingko leaf, filler, disintegrant, flavouring, flowing aid, lubricant, etc.

Description

[Technical Field] [0001] The invention relates to a pharmaceutical preparation for treating cardiovascular and cerebrovascular diseases, in particular to an orally disintegrating tablet for treating coronary heart disease, angina pectoris, acute cerebral infarction, and cerebral arteriosclerosis or cerebral circulatory disorders. [Background technique] [0002] Ginkgo biloba is also known as Ginkgo biloba. Ginkgo biloba was used as a medicine since the Ming Dynasty. According to records, it was used to treat lung deficiency, cough, asthma and heart disease. At present, it is clinically used for the treatment of cardiovascular and cerebrovascular diseases, asthma, and peripheral vascular diseases. In recent years, most of the Ginkgo biloba extract is used as a raw material, and a variety of different dosage forms are made with modern preparation technology for the convenience of patients and medical workers. [0003] 1. Pharmacology and efficacy [0004] Ginkgo biloba extract (GbE...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/20A61K36/16A61K47/00A61P9/10
CPCA61K9/0056A61K36/16A61P9/10
Inventor 蒋海松王锦刚
Owner GUIZHOU YIBAI PHARMA CO LTD
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