Art for synthesizing acetylide of coenzyme Q10 intermediate

Abstract

A synthesis process for ethynyl compounds - an intermediate of a coenzyme Q10. This invention is for improving existing techniques problems of high cost for ethynylation, apparent safety risk and environmental pollution etc. The main points of the technique: during the preparation process of coenzyme Q10 from semi-synthesis method, the solane-acetone through ethynylation from introducing ethynyl to produce 3-methyl-solane-butynyl-1-alcohol-3 synthesis technique. The synthesis technique is characterized by fist adding appropriate sodium hydroxide or potassium hydroxide alcohol solution and toluene into a reaction vessel, heating and refluxing reactants to make the reaction completely, separating water, the reaction liquid cooled down, ethyne going through the solution to get a ethyne reaction solution, adding the solane-acetone solution into the ethyne reaction solution to make the reaction happen, after the reaction, adding appropriate water, cooling and neutralizing with acidic solution, separating water and organic layer, washing the organic layer with water, heated to remove organic solvent, 3-methyl- solane-butynyl-1-alcohol-3 is produced.

Description

technical field [0001] The invention relates to a semi-synthetic method for preparing coenzyme Q 10 Preparation method of intermediate substances in the process, especially coenzyme Q 10 Synthetic process of intermediate acetylides. Background technique [0002] coenzyme Q 10 It is a fat-soluble quinone compound widely present in living organisms, chemical name: 2,3-dimethoxy-5-methyl-6-decyl isoprenyl-1,4-benzoquinone, chemical structural formula : [0003] [0004] Studies have shown that coenzyme Q 10 It plays an important role in proton translocation and electron transfer in the human respiratory chain. It can be used as an activator of cell metabolism and cellular respiration, as well as an important antioxidant and non-specific immune enhancer. It can promote oxidative phosphorylation and protect the integrity of biofilm structure. sex. Clinically, coenzyme Q 10 It can be used as an adjuvant drug for congestive heart failure, coronary heart disease, hypertens...

AI Technical Summary

Problems solved by technology

However, the U.S. patent of method 2 requires vinyl bromide with a low boiling point as a raw material, and method 3 also uses vinyl chloride with a low boiling point as a raw material. When a large number of applications are used, there are inconveniences in storage and transportation, and there are difficulties in large-scale industrial application.

Method 1 is an ideal method for introducing an isoprenyl group into solanesol, but the problem with method 1 is that liquid ammonia and metal sodium are used when introducing ethynyl groups for ethynylation, which are dangerous goods and are not Pressurized reaction is required, not only the process cost is high, but also there are obvious safety problems in use; the liquid ammonia cannot be fully recovered during post-processing, and the liquid ammonia is easy to escape, which will cause environmental pollution

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