69 results about "Diseases onset" patented technology

The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and / or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of signal at selected values in k-space, with multiple successive acquisitions at individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only signal values at select places in k-space, along selected directions, enables much higher in vivo resolution than is obtainable with current MRI techniques.

Methods and pharmaceutical compositions are disclosed, effective in breaking-down immunological tolerance the CXC chemokine interferon gamma-inducible protein 10 (IP-10), resulting in the generation of self specific immunity to IP-10, for the treatment of diseases, such as autoimmune diseases, in which IP-10 plays a pivotal role in disease onset and / or progression, e.g., in multiple sclerosis (MS).

The invention discloses a processing system of human body health data and a method thereof. The processing system comprises an acquisition unit, a first processing unit, a second processing unit, a computing unit and an output unit. The acquisition unit is used for obtaining physical sign data of healthy state of an individual through an APP application; the first processing unit is used for carrying out healthy features construction on the physical sign data by using a vector space modal; the second processing unit is used for extracting features, constructing a data set, and detecting denoising and reconstitution of the data through the features; the computing unit is used for digging and determining healthy impact factors which impact the corresponding individual; the output unit is used for generating a healthy analysis result of the corresponding individual as well as information about guidance and suggestions. The processing system of human body health data and the method thereof have the advantages that through techniques such as data automatic detection, mobile computing, information extraction, association digging, neutral network and machine learning, determining individual health state and developmental tendency from individual health data, conducting continuously trailing and real-time warning, analyzing healthy impact factor, promoting individual health level, carrying out prevention before disease onset, preventing disease from exacerbating and guiding the individual to adopt a most appropriate health behavior. The processing system of human body health data and method thereof are very convenient to realize.

The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in-vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and / or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of selected values in k-space, with multiple successive acquisitions of individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only select values in k-space along selected directions, enables much higher in-vivo resolution than is obtainable with current MRI techniques.

The invention relates to medicinal liquor, and aims to provide the medicinal liquor capable of synchronously tonifying qi, blood, yin and yang. The medicinal liquor is prepared by adding raw medicaments in an amount which is 1 / 16 to 1 / 12 of the weight of white spirit into 50 to 60 percent white spirit. The raw medicaments contain 55 to 65 parts of bunge auriculate root, 1 to 3 parts of lucid ganoderma, 1 to 2 strains of boschniakia rossica, 45 to 55 parts of Chinese angelica, 55 to 65 parts of songaria cynomorium herb, 1 to 2 pairs of geckoes, 1 to 2 grains of ginseng, 55 to 65 parts of red morning glory, 8 to 12 parts of pipe fish, 55 to 65 parts of achyranthes root and 1 to 2 grains of snow lotus herb. The liquor is prepared by using the Chinese medicinal concepts of integrally 'securing root and strengthening kidney' and 'preventing before disease onset', and has double functions of treatment and health care.

The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in-vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and / or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of selected values in k-space, with multiple successive acquisitions of individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only select values in k-space along selected directions, enables much higher in-vivo resolution than is obtainable with current MRI techniques.

The invention belongs to the field of medical detection, and particularly discloses an improved Alzheimer disease onset risk prediction method. The method puts forward an improved wGRS (Genetic Risk Score) method based on traditional wGRS, the function of single SNP (Single nucleotide polymorphisms) is considered during wGRS calculation, and meanwhile, the mutual function of SNPs is also considered. According to the improved wGRS method, the accuracy of Alzheimer disease onset risk prediction is further improved. Therefore, the method takes the important influence of the mutual function of the SNPs on the Alzheimer disease into consideration, and the mutual function of the SNPs is applied to the Alzheimer disease onset risk prediction to further improve the accuracy of the Alzheimer disease onset risk prediction.

The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in-vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and / or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of selected values in k-space, with multiple successive acquisitions of individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only select values in k-space along selected directions, enables much higher in-vivo resolution than is obtainable with current MRI techniques.

The invention discloses a human health sleep type remote monitoring and serving system which comprises sensors, a digital collection box and a monitoring and serving center. The sensors include a weight sensor, a temperature sensor, a humidity sensor, a vibration sensor and a voice sensor which are distributed in a bed and a pillow of a monitored person, the digital collection box comprises a multiway switch, a signal conditioning circuit, an analog-digital conversion circuit, a processor, a storer and an interface circuit, the sensors are connected with the multiway switch which is connected with the signal conditioning circuit, the signal conditioning circuit is connected with the analog-digital conversion circuit, the analog-digital conversion circuit, the storer and the interface circuit are all connected with the processor, and the interface circuit and the monitoring and serving center are connected in a wired and / or wireless manner. By the human health sleep type remote monitoring and serving system, health conditions of middle-aged and elderly people can be monitored for a long time, suggestions on healthcare, disease prevention and timely treatment receiving and body alarming can be provided to users, and product and technology support is provided for health concept and practice of prevention before disease onset, treatment before disease onset and timely treatment receiving after disease onset.

The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and / or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of signal at selected values in k-space, with multiple successive acquisitions at individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only signal values at select places in k-space, along selected directions, enables much higher in vivo resolution than is obtainable with current MRI techniques.

The present invention relates to a method for identifying a DNA breakpoint and agents for use therein. More particularly, the present invention provides a method for identifying a gene translocation breakpoint based on the application of a novel multiplex DNA amplification technique. The method of the present invention facilitates not only the identification of the breakpoint position but, further, enables the isolation of the DNA segment across which the breakpoint occurs. This provides a valuable opportunity to conduct further analysis of the breakpoint region, such as to sequence across this region. The method of the present invention is useful in a range of applications including, but not limited to, providing a routine means to characterise the gene breakpoint associated with disease onset in a patient and thereby enable the design of patient specific probes and primers for ongoing monitoring of the subject disease condition. In addition to monitoring the progression of a condition characterised by the existence of the breakpoint, there is also enabled assessment of the effectiveness of existing therapeutic drugs and / or new therapeutic drugs and, to the extent that the condition is a neoplasm, prediction of the likelihood of a subject's relapse from a remissive state.

A method and composition for preventing prostate cancer and / or reducing PSA levels and / or alleviating the symptoms of BPH (Benign Prostatic Hyperplasia) or PIN (prostatic intraepithelial neoplasia) by administration of an effective amount of a mixture of flavopereirine and alstonine. A method and composition for treating low-grade prostate cancer and preventing the onset of metastatic disease and / or reducing the doubling time of PSA levels in men with positive biopsies showing relatively low Gleason scores and morphologies characteristic of non-invasive, slow-progressing prostate cancer. The flavopereirine and alstonine can be in the form of natural extracts derived from Pao Pereira and Rauwolfia Vomitoria, respectively. Alternatively, these two active compounds can be administered in purified form. The composition can be in included in a kit along with instructions for use in a treatment regimen.

The invention discloses a qi-blood body fluid network dynamic identification device and method for biological information of salivary secretion, sweating and urine excretion. The identification device is composed of microcosmic camera of mouth cavity and a tongue, a lingual surface blood flow detection device, an impedance blood flow detection device for the inner sides of two cheeks and the tongue, a calibration siphon capillary and a body fluid collection tube; dynamically acquiring and contrastively analyzing physicochemical and physiological features of salivary secretion, sweating, blood flow and urine excretion, the relevance ratio of iconic substances and the like; and establishing information obtained by the device and a multilevel topology network of four diagnostic methods information. A statistical identification mode or a BP (Back Propagation) neural network identification mode by virtue of qi, blood, clear fluid and liquid of traditional Chinese medicine, so that a new network identification mode, with multiple information fusion, of correlation of all four examinations of the traditional Chinese medicine. The device and the method can be used for the identification of the health condition and qi-blood body fluid and clinical diagnosis and treatment, can be also used for prevention before disease onset and scientific researches.

The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in-vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and / or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of selected values in k-space, with multiple successive acquisitions of individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only select values in k-space along selected directions, enables much higher in-vivo resolution than is obtainable with current MRI techniques.

The present invention provides methods for identifying genes, expression regulators, receptors, protein product receptors, and proteins that may regulate rhinovirus infections. The genes identified may be used as markers for disease onset and progression and to measure efficacy of a therapeutic. The present invention also provides methods to screen agents that are capable of regulating rhinovirus infection. The present invention also provides methods of identifying therapeutic compounds that may treat various disorders by regulating the expression and activity of genes, expression regulators, receptors, protein product receptors, and proteins identified.

The present disclosure relates to a method and an apparatus for predicting an outbreak of disease. An exemplary embodiment of the present disclosure provides a disease outbreak predicting method including: receiving original data including a plurality of fields from at least one external database; generating processing data, wherein each of processing data represents one medical treatment or one health examination as one event in accordance with a predetermined criteria based on the original data; inputting the processing data into a disease outbreak predicting model; and calculating a disease outbreak probability for at least one disease using the disease outbreak predicting model. The present disclosure provides a disease outbreak predicting method and a disease outbreak predicting apparatus which represent various types of health related data as one event to input various data to a disease outbreak predicting model.

The invention discloses a Chinese medicament for treating cardiovascular and cerebrovascular diseases, which consists of American ginseng and sanchi, wherein a weight ratio of the American ginseng to the sanchi is 1-9:9-1. The American ginseng and the sanchi are micro powders which are subjected to ultramicro wall-breaking crushing. The patent medicine is prepared into 4 grams per bag of soluble granules, or 0.4 grams per capsule of capsules, or 1 gram per tablet of tablets with auxiliary materials. The American ginseng and sanchi soluble granules, capsules or tablets of the invention have good curative effect of treating cardiovascular and cerebrovascular diseases of middle-aged and elderly people, in particular to arteriosclerosis, hypertension, hyperlipemia, heart disease, diabetes mellitus and the like, also can be used as the health care food, have effects of preventing before disease onset, treating disease, preventing thrombosis senescence and eliminating disease and prolonging life and have obvious long term effect and no any side effects.

A method and composition for extending the lifespan of an individual and delaying the onset of age-related disease is provided. The method includes the administration of an effective dose of oxaloacetate, wherein the oxaloacetate acts to mimic the cellular conditions obtained under caloric restriction to provide similar benefits. The invention further includes methods and compositions for reducing the incidence or treatment of cancer. Compositions and methods for reducing body fat by administering an effective amount of oxaloacetate are likewise provided. Compositions for DNA repair in UV damaged cells is provided are also provided. Similarly, a method for treating a hang-over comprising administering an effective amount of oxaloacetate is disclosed.

Infection by Chlamydia pneumoniae has been identified as a risk factor associated with the pathogenesis of certain chronic intraocular disorders, for example, age-related macular degeneration. The invention provides methods of identifying individuals at risk of developing chronic intraocular disorders, and methods of delaying and / or preventing the onset of such chronic intraocular disorders.

The invention discloses a method and device for interplanting konjac under a walnut forest. The method is characterized by comprising the steps: A. popularizing and applying a detoxified konjac variety; B. popularizing a ridge-culture cultivation technique; C. popularizing a formula fertilizing technique; D. popularizing a pollution-free production technique; E. changing untreated seed konjac sowing into sowing after seed sun-curing and seed soaking treatment with a pesticide; F. changing plowing and land preparation before spring sowing into frozen upturned soil plowing in winter and land preparation in spring; G. changing soil untreatment during land preparation into soil disinfection treatment with quicklime during land preparation; H. changing open field cultivation into film mulchingcultivation; and I. changing pesticide spraying control after disease onset into comprehensive prevention with prevention first combined with pesticides. The device is characterized by comprising an electromotor, brackets, a transmission case, a plastic roll film, an uncovered tank body and the like. The method and the device have the beneficial effects that the utilization rate and yield rate ofland are increased; the problem of variety nature degeneration of the konjac is solved, loss caused by disease damage is reduced, and the yield and quality of the konjac are improved; and multiple functions, i.e., pitting, sowing, fertilizing, watering, pesticide broadcasting, soil covering and film mulching are achieved.

The invention provides application of an antibiotic substitute drug melatonin in preventing the infection of meningitis escherichia coli pathogens on child patients. Meningitis-type escherichia coli is separated and identified from muscovy duck cerebrospinal fluid, a meningitis model of 3-week-old ICR mice is constructed for the first time by utilizing the strain, and the successful construction of the mouse meningitis model is evaluated from the aspects of neurological symptom scoring, mortality difference statistics, the damage degree of a blood-brain barrier, expression of meningitis-related inflammatory factors and the like respectively. With antibiotics as references, the mice are treated with the melatonin and the four combined antibiotics respectively, one week later, the disease onset conditions of the meningitis mice are detected, results show that through the melatonin and the combined use of the antibiotics, the neurological symptoms of the meningitis mice can both be reduced, the survival rate of the meningitis mice is increased, integrity keeping of the blood-brain barrier is promoted by the melatonin, the invasion of inflammatory cells into the central nervous systemis reduced, the disease onset of the meningitis in the mice is prevented through the function of the brain-gut axis, and a new antibiotic substitute and treatment strategy are provided for preventingneonatal meningitis diseases.

The invention discloses a dampness-eliminating traditional Chinese medicine composition for treating cold and cough and a preparing method thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises, by weight, 5-12 parts of herba elsholtziae, 7-15 parts of herba schizonepetae, 15-25 parts of Chinese wax gourd peel, 7-15 parts of dried tangerine peel, 5-12 parts of blackberrykiky rhizome, 10-18 parts of bulbus fritillariae cirrhosae, 5-12 parts of platycodon grandiflorum, 10-18 parts of folium eriobotryae, 10-18 parts of folium mori, 10-18 parts of saxifraga stolonifera, 5-12 parts of cortex magnoliae officinalis and 5-12 parts of licorice root. The various natural traditional Chinese medicine raw materials are preferentially selected for use in cooperation to have the functions of dispelling wind and heat, dispelling wind and relieving exterior syndromes, eliminating dampness and eliminating phlegm, removing heat from the lung to relieve cough, eliminating phlegm and relieving asthma, and clearing heat and relieving sore throat; the traditional Chinese medicine composition can be used for treating the influenza fever, headache and cough, muscular stiffness, throat dryness and pains and other symptoms, is suitable for the cold incubation period or disease onset period, can effectively prevent the cough, throat swelling and pains and other symptoms caused by cold in the later period, and is precise in treatment effect, safe and free of side effects.

Methods are provided for diagnosing and / or characterizing chronic immune disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to have a chronic immune disease. The sample is then assayed for the presence of low molecular actin fragments. The assay results are used to diagnose the presence of chronic immune disease activity and / or characterize chronic immune disease activity in the subject, e.g. to confirm an initial chronic immune disease diagnosis, to determine the stage of the disease, to monitor disease progression, to predict disease attacks, and the like. Also provided by the subject invention are kits for practicing the methods.

The present invention relates to the identification and diagnostic use of biomarkers in primary colorectal cancer tumors whose activation level are predictive of the likelihood of the onset of metastatic disease. These biomarkers may be used to determine the suitability of a patient for aggressive and / or targeted treatments. Kits and compositions of the invention are also provided.

The invention relates to stabilizing chairs and particularly relates to a stabilizing chair for an epilepsy sufferer for a neurology department. The stabilizing chair for the epilepsy sufferer for the neurology department, provided by the invention, has the advantages that the sufferer can be fixed under the condition of not injuring the sufferer, a majority of light rays can be shaded, and the condition that relatively intense response is generated due to irritation to eyes of the sufferer caused by the light rays is prevented. The stabilizing chair for the epilepsy sufferer for the neurology department comprises a base and a chair, wherein the chair is arranged on the base and is provided with a cushioning mechanism, and a hand supporting mechanism is arranged between the base and the chair. According to the stabilizing chair, through the cushioning mechanism and the hand supporting mechanism, the hand supporting mechanism is used for placing hands of the sufferer, and meanwhile, the cushioning mechanism can be used for performing cushioning when the sufferer sits down, so as to achieve the effect of reducing an impact force when the sufferer sits down; and through arranging a leg limiting mechanism and a clamping mechanism, legs of the sufferer can be fixed, and the sufferer is prevented from kicking in medical personnel during disease onset.

The invention provides a compound raspberry health wine and a preparation method thereof. The compound raspberry health wine is mainly prepared from the following raw materials in parts by mass: 25-40 parts of raspberry, 10-25 parts of cranberry, 10-20 parts of mulberry, 5-15 parts of cornus officinalis, 5-15 parts of purple berry, and 5-10 parts of blackberry. The method provided by the invention uses fresh fruit as raw materials and adopts a modern production technology; no chemicals are added; various natural organic berries are compounded in an assistant and guide manner and brewed elaborately; effective constituents are completely preserved, the activity of the effective constituents is increased, and the medicinal value of the original berries is improved; in addition, under the solvent action of wine, the drug resorts to the wine and the wine resorts to the drug efficacy, so that the yin-yang, qi-blood and viscera of the human body are regulated, the aging of human body is delayed, sub-health status is eliminated, diseases are prevented, and the purpose of prevention before disease onset is achieved.

The invention discloses a cerebrovascular disease high-risk population risk prediction method based on climatic factors. At present, research and application of cerebrovascular disease onset prediction which is specially designed for cerebrovascular disease onset data analysis and is combined with climate factor data do not exist. The method comprises the following steps: firstly, acquiring and preprocessing data; dividing climate factor indexes, and screening influence significant climatic factor indexes; substituting the number of patients with various cerebrovascular diseases and the corresponding characteristic climate factor indexes into a CME cross map scoring framework; calculating the CME score S (tau) to obtain a relation curve of the time delay tau and the S (tau); and taking thetime point corresponding to the point with the highest S (tau) as the predicted time point with the highest cerebral vascular disease onset risk in a future period of time in the time sequence. According to the invention, climate factors can be effectively analyzed, the attack risk degree of cerebrovascular disease high-risk groups can be predicted, scientific guidance is provided for medical experiment verification, and the disease early warning efficiency is improved.

A method and composition for preventing prostate cancer and / or reducing PSA levels and / or alleviating the symptoms of BPH (Benign Prostatic Hyperplasia) or PIN (prostatic intraepithelial neoplasia) by administration of an effective amount of a mixture of flavopereirine and alstonine. A method and composition for treating low-grade prostate cancer and preventing the onset of metastatic disease and / or reducing the doubling time of PSA levels in men with positive biopsies showing relatively low Gleason scores and morphologies characteristic of non-invasive, slow-progressing prostate cancer. The flavopereirine and alstonine can be in the form of natural extracts derived from Pao Pereira and Rauwolfia Vomitoria, respectively. Alternatively, these two active compounds can be administered in purified form. The composition can be in included in a kit along with instructions for use in a treatment regimen.

Given free recall or recognition test results of normal and disease populations, the present innovation provides methods for determining how close a single test subject is to the profile of a diseased population. The methods use the total items remembered and a defined recency-primacy shift to determine how similar the test subject is to a disease population. The methods are well defined and do not involve any “tinkering”.