The invention relates to a sterilization combination containing meptyldinocap and pyrametostrobin. The effective components of the sterilization combination are the meptyldinocap and the pyrametostrobin which are compounded in a binary mode. The mass ratio of the meptyldinocap and the pyrametostrobin is 1-50:50-1, the mass fraction ratio of the effective components of the meptyldinocap and the pyrametostrobin in the sterilization combination is 1% to 80%, and the other components are auxiliary components allowed and accepted in pesticide. The dosage form of the sterilization combination comprises missible oil, suspending agents, wettable powder, water aqua, water dispersible granules, emulsion oil in water, microemulsion, granula, and microcapsule formulation. The sterilization combination is mainly used for preventing and treating powdery mildew of apples, citruses, pears, grapes, cucumbers, melons, watermelons, pumpkins, strawberries, roses, ornamental plants and cereal crops, downy mildew of vegetables, grapes, tobacco, lupulus and other crops and the like.