The invention discloses an intelligent sterilization and disinfection device for medical equipment. The device comprises a cleaning box body, a high-pressure fan, a mounting plate, a water distributor, a liquid inlet pipeline, a placement frame, a partition rod, a limit frame, a guide cover, a waste collection frame, a filter screen, a liquor drainage pipeline and a driving assembly. According tothe intelligent sterilization and disinfection device for the medical equipment, cleaning liquid is transported through the liquid inlet pipeline, the cleaning liquid is conveniently distributed through the water distributor, the driving assembly vibrates the placement frame, impurities on the medical equipment are conveniently vibrated during the cleaning process, the filter screen in the waste collection frame filters the impurities in waste liquid, and then the filtered waste liquid is discharged through the liquor drainage pipeline, so that the impurities in the waste liquid are avoided from blocking the liquor drainage pipeline, and the high-pressure fan air-dries the cleaned medical equipment in real time; and in addition, due to the fact that the waste collection frame is slidably connected with the cleaning box body, a user can conveniently remove the impurities in the waste collection frame in time.