The invention provides sealed mixing equipment capable of performing secondary charging, which comprises a mixing barrel and a barrel cover, and a stirring shaft is arranged in the mixing barrel; a first feeding pipe is arranged on the side wall of the mixing barrel in a communicating manner, and a first electromagnetic valve is arranged on the first feeding pipe; a second feeding pipe is arranged on the barrel cover, a second electromagnetic valve is arranged on the second feeding pipe, a transfer box is arranged at the top end of the second feeding pipe, a third feeding pipe is arranged on the side wall of the transfer box, and a third electromagnetic valve is arranged on the third feeding pipe; a buffer pipe is arranged on the outer side of the top of the mixing barrel, the bottom end of the buffer pipe is communicated with the interior of the mixing barrel, a limiting frame is arranged on the inner wall of the bottom end of the buffer pipe, an end cover is arranged at the top end of the buffer pipe, a piston block is arranged in the buffer pipe, and the piston block slides along the inner wall of the buffer pipe in a sealed mode to achieve adjustment of air pressure; the device is novel in structure, materials can be conveniently added in the mixing process, the change of air pressure can be reduced as much as possible, the air pressure can be subsequently adjusted in an auxiliary mode, and the proper internal air pressure condition is maintained.