The invention provides a detachable handle device with a multi-locking function. The detachable handle device comprises a sliding plate, an upper locking block, a push button, an upper cover, a lower cover, a sliding plate spring, an upper locking block spring, an upper unlocking button, a lower locking block spring, a lower unlocking button, a gusset plate and a gusset plate spring. The push button can drive the sliding plate to move front and back, the front of a handle cavity is provided with the upper unlocking button and an upper locking block groove, a spring and the upper locking block are arranged in the upper locking block groove, and upward force of the spring is always exerted on the upper locking block; the lower unlocking button and a lower locking block groove are formed behind an upper locking assembly, and a gusset plate is arranged at the tail end of the sliding plate; the upper locking assembly, the lower locking assembly and the rear end gusset plate are matched to lock the handle. The pot handle is convenient to disassemble freely, one pot handle can be matched with multiple pots, and the handle is convenient to assemble and disassemble and matched with the multiple pots. Meanwhile, because the multiple locking assemblies are arranged, it can be prevented that the pot handle automatically falls off when external force or misoperation occurs, and using safety is higher.