The utility model discloses a kind of waterproof male and female plugs of high sealing property, belong to plug technical field, including female plug and male plug, female plug and male plug are plugged together, the outside of female plug and male plug is equipped with anti-falling sealing mechanism, and anti-falling sealing mechanism includes O type sealing ring, connecting ring, arc rotating plate, fixed rod, compression spring and L shape limit board, O type sealing ring is nested on the outer wall of female plug right side ring, the use of the anti-falling sealing mechanism cooperation female plug and male plug, the connection strength between male and female plug can be improved, avoid male and female plug under external force and occur displacement, separate and fall off problem, to play the protection effect of anti-falling after connecting female plug and male plug, ensure that female plug and male plug keep close and fit, prevent sealing structure and appear gap, guarantee the uniform pressure of sealing structure to contact surface, to reach the purpose of improving the sealing waterproof performance of male and female plug connection use.