6results about How to "Solve practical problems" patented technology

This invention discloses an adjustable end-sealing device for a multi-diameter pipe hydraulic testing machine. The device includes a pair of opposing end plates, at least one set of wedge-shaped sealing units comprising wedge-shaped sealing blocks and caps, and a synchronous drive mechanism consisting of at least three adjusting screws and locking nuts. Tightening the locking nuts causes the two end plates to move closer together, thereby synchronously pushing all the wedge-shaped sealing blocks radially inward. The smooth inclined surfaces of the wedge-shaped sealing blocks directly compress the outer walls of pipe ends of different diameters, achieving high-pressure sealing without independent sealing rings through the deformation of the pipe itself. This invention provides a single device that can be adapted to seal various pipe diameters, offering advantages such as high versatility, reliable sealing, simple operation, robust structure, and long service life.

The application discloses an industrial sensor data anomaly detection and repair method based on an attention mechanism, belongs to the technical field of industrial data processing, and carries out preprocessing on original data to obtain standardized data segments, a training set and a test set; end-to-end collaborative training is carried out on the training set to obtain a dynamic space-time attention detection model and a multi-scale self-attention repair model; the standardized data segments are input into the dynamic space-time attention detection model for anomaly detection to obtain abnormal related information; the standardized data segments and the abnormal related information are input into the multi-scale self-attention repair model for data repair to obtain repaired data; secondary verification and parameter fine-tuning operations are performed on the repaired data to obtain compliant repair data; and the POT algorithm is used to dynamically adjust an abnormality judgment threshold value, and normal industrial sensor data or compliant repair data is output. By using the above method, accurate detection and compliant repair of industrial sensor data anomalies are realized.

This invention discloses the use of oligomycin A in the preparation of a drug for competitively inhibiting EphB3 to reverse lorlatinib resistance, belonging to the field of biomedical technology. This invention experimentally discovered that EphB3 is a key factor mediating lorlatinib resistance in lung cancer, and that existing oligomycin A can effectively reverse EphB3-mediated resistance by competitively binding to EphB3. Based on this, this invention protects the use of oligomycin A in the preparation of a drug for reversing lorlatinib resistance in tumors (especially ALK-positive non-small cell lung cancer). Simultaneously, this invention also protects a therapeutically effective pharmaceutical composition comprising oligomycin A and lorlatinib, and a non-therapeutic method for reversing cellular resistance to lorlatinib in vitro. This invention provides a novel and effective solution for overcoming lorlatinib resistance in clinical practice.

The application discloses a collagen domain, a collagen protein, a recombinant collagen protein expression bacterium and application, and belongs to the field of genetic engineering. The application carries out stability prediction and sequence design on human collagen protein, obtains a collagen protein domain with high homology with natural human collagen protein, and directly expresses the recombinant human collagen protein with a triple helix structure in Escherichia coli. The high-thermal-stability collagen protein fragments designed in the application can correctly fold to form a triple helix structure, while the low-thermal-stability fragments cannot correctly fold. The high-thermal-stability recombinant human type I collagen designed in the application can self-assemble to form periodic light and dark stripes similar to natural type I collagen. The collagen domain and the collagen protein can be used in the biomedical and tissue engineering fields of the structure-function bionic recombinant collagen protein, and can be used in tissue culture, tooth tissue repair and the like.

The utility model discloses a kind of calibration device for body temperature monitoring bracelet, it is related to product calibration technical field, and its technical solution main point is: the inside of the imitation leather layer is equipped with the first probe of detecting the temperature inside imitation leather layer, the inside of the heating matrix is equipped with the second probe of detecting the temperature inside heating matrix, the first probe and the second probe are connected with the temperature control box of outside, effect is through the curvature radius matching human wrist arc of elliptic cylinder heating matrix, eliminate the contact thermal resistance deviation caused by traditional calibration equipment in midair, the double repetition of the thermal conductivity and the flexible deformation characteristics of imitation leather layer, ensure that the degree of fit of equipment sensor and real wear are consistent.

The invention discloses an aluminum alloy additive manufacturing strengthening and toughening method combining ultrasonic peening and heat treatment, and belongs to the technical field of metal additive manufacturing aftertreatment. The method sequentially comprises the following steps that firstly, a CMT technology is adopted, 7000 series aluminum alloy serves as a base plate, and aluminum-lithium alloy welding wires serve as filling materials for additive manufacturing; secondly, the surface of the manufactured part is subjected to ultrasonic impact treatment; and then, solution treatment and aging treatment are carried out. According to the method, through organic combination and sequential cooperation of the three processes, the technical problems that due to rapid cooling, residual stress is large, dispersed phase distribution is uneven, and obdurability and toughness are difficult to consider are effectively solved, the comprehensive performance of the material can be remarkably improved, the tensile strength is improved by 282.7% or above, and the service life of the material is prolonged. The elongation after fracture is improved by 543.5% or above, and the aluminum alloy is particularly suitable for preparing high-performance aluminum alloy components in the fields of aerospace and the like.