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Pharmaceutical composition of red sage root and cassia twig

A composition and drug technology, applied in the field of medicine, to achieve the effects of prolonging the time of thrombus formation, good stability of preparations, and controlling product quality

Inactive Publication Date: 2008-05-14
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, the interaction between salvia miltiorrhiza or salvia miltiorrhiza extract and cassia twig or cassia twig extract is used to prepare medicines for treating cardiovascular and cerebrovascular diseases. See the report

Method used

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  • Pharmaceutical composition of red sage root and cassia twig
  • Pharmaceutical composition of red sage root and cassia twig
  • Pharmaceutical composition of red sage root and cassia twig

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Preparation and assay of embodiment 1 salvia miltiorrhiza extract

[0088] 1. Preparation of Salvia Miltiorrhiza Extract

[0089] Take Danshen medicinal material, crush it into coarse powder, add water to decoct twice, add 12 times of water for the first time, add 10 times of water for the first time, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to relative density under reduced pressure 1.10~1.15 (60°C) concentrated solution, add ethanol until the alcohol content reaches 85%, refrigerate for 24 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add hydrochloric acid to adjust the pH value to 2, shake with ethyl acetate Extracted 3 times, combined ethyl acetate solution, and evaporated to dryness. The residue was dissolved in acidic water with a pH value of 2, added to the treated polyamide column, first eluted with 2 times the column volume of water, discarded the water washing solution, and then...

Embodiment 2

[0103] Preparation and assay of embodiment 2 cassia twig extract

[0104] 1. Preparation of Cinnamon Twig Extract

[0105] Cinnamomum twig herbs are crushed to a certain particle size, put into the extraction kettle, and the SFE system is heated. The primary separation temperature is 55°C, the pressure is 30Mpa, the extraction temperature is 60°C, the secondary separation pressure is 20Mpa, and the temperature is 50°C. The time is 3 hours, and the material is discharged from the primary and secondary separation kettles.

[0106] 2. Determination of the content of cassia twig extract

[0107] Determination of cinnamic aldehyde content

[0108] Gas Chromatography:

[0109] Chromatographic conditions and system suitability test: polyethylene glycol (PEG)-20M was used as the stationary phase, the coating concentration was 10%; the column temperature was 190°C. The theoretical plate is not less than 3000.

[0110] Preparation of the reference substance solution: Take an appr...

Embodiment 3D

[0116] The preparation of embodiment 3DG tablet

[0117] Prescription one:

[0118] Salvia miltiorrhiza extract 18g (equivalent to 1kg of raw medicinal material)

[0119] Cinnamomum twig extract 24g (equivalent to 2kg of raw medicinal materials)

[0120] 120g pregelatinized starch

[0121] Microcrystalline Cellulose 40g

[0122] Low-substituted hydroxypropyl cellulose 40g

[0123] 2% HPMC aqueous solution appropriate amount

[0124] Magnesium Stearate 6g

[0125] Carboxymethyl Starch Sodium 12g

[0126]

[0127] A total of 1000 tablets were prepared

[0128] Prescription two:

[0129] Salvia miltiorrhiza extract 32.4g (equivalent to 1800g of raw medicinal materials)

[0130] Guizhi Extract 4.8g (equivalent to 400g of raw medicinal materials)

[0131] 120g pregelatinized starch

[0132] Microcrystalline Cellulose 40g

[0133] Low-substituted hydroxypropyl cellulose 40g

[0134] 2% HPMC aqueous solution ap...

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Abstract

The invention belongs to the technical field of medicine, and discloses a pharmaceutical composition of salvia miltiorrhiza or its extract and cassia twig or its extract and a preparation method thereof, its application in preparing medicine for treating cardiovascular and cerebrovascular diseases, and a preparation containing the pharmaceutical composition . Calculated according to the weight components, the composition of the raw material medicine containing the medicinal ingredients contained in it is: 200-5000 parts of Danshen, 100-2000 parts of Guizhi, or: 3-100 parts of Danshen extract, 1 part of Guizhi extract ~30 servings. It can be made into any clinically or pharmaceutically acceptable dosage form, preferably oral preparation or injection. The two medicines in the pharmaceutical composition of the invention have synergistic effect, and the therapeutic effect is greatly improved compared with the single use of salvia miltiorrhiza or its extract and cassia twig or its extract. Work together to play anti-myocardial ischemia, anti-thrombosis, anti-cerebral ischemia-reperfusion injury and other effects.

Description

[technical field] [0001] The invention relates to a pharmaceutical composition of salvia miltiorrhiza or its extract and cassia twig or its extract, a preparation method thereof, an application in preparing medicine for treating cardiovascular and cerebrovascular diseases, and a preparation containing the pharmaceutical composition, belonging to the technical field of medicine. [Background technique] [0002] Cardiovascular and cerebrovascular diseases include coronary heart disease, angina pectoris, myocardial infarction, congestive pulmonary heart disease, ischemic encephalopathy, cerebral thrombosis, hypertension, hyperlipidemia, etc. The main cause of these diseases is that arteriosclerosis causes narrowing of the lumen and blockage of the pipeline, which leads to insufficient blood supply to the heart and brain, causing symptoms such as dizziness, dizziness, headache, and chest tightness. In severe cases, it can lead to stroke and myocardial infarction. Cardiocerebral i...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61P9/10A61P9/12A61P7/02A61P3/06
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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