Novel process for synthesizing polyatomic alcohol ester by lipase catalysis

A polyol ester, lipase technology, applied in the direction of organic chemistry, petroleum industry, lubricating composition, etc., can solve the problems of poor selectivity, harmful catalysts, and many by-products, etc., to improve reaction activity and stability, and mild reaction conditions. , the effect of eliminating negative effects

Inactive Publication Date: 2009-07-08
北京润华源天生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the chemical catalyst can make the reaction obtain a relatively ideal esterification rate, the method using the chemical catalyst has the following disadvantages: 1) the reaction is often accompanied by side reactions such as oxidation, carbonization, polymerization, rearrangement, poor selectivity, and by-products in the reaction Many, the post-treatment process of the product is complicated, the purification of the esterified product is difficult, the production cost is high, and the product quality is affected; 2) the process is complicated, alkali neutralization and washing are required, the sewage discharge is large, and the environment is

Method used

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  • Novel process for synthesizing polyatomic alcohol ester by lipase catalysis
  • Novel process for synthesizing polyatomic alcohol ester by lipase catalysis
  • Novel process for synthesizing polyatomic alcohol ester by lipase catalysis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Methyl oleate and trimethylolpropane (13.57g) with a molar ratio of 3.1:1 were added to a rotary evaporator, and immobilized lipase Novozym 435 with 10% of the mass of methyl oleate was added, and trimethylolpropane tert-butanol with 350% propane quality, the transesterification reaction is first carried out at 20KPa vacuum degree, 40°C, 200 rpm for 8h; then, tert-butanol is distilled at 5KPa vacuum degree, 40°C temperature; Next, the transesterification reaction was continued at 5KPa vacuum degree, 40° C., and 200 rpm for another 24 hours, and the yield of trimethylolpropane oleate was 95.8%.

Embodiment 2

[0033] Methyl oleate and neopentyl glycol (18.43 g) with a molar ratio of 2.1:1 were added to a rotary evaporator, and immobilized lipase Novozym 435 with 10% of the mass of methyl oleate was added, and neopentyl For tert-butanol with a diol quality of 300%, the transesterification reaction is first carried out at 20KPa vacuum, 40°C, and 200 rpm for 8 hours; then, tert-butanol is distilled at 5KPa vacuum and 40°C; Secondly, the transesterification reaction was continued at 5KPa vacuum degree, 40° C., and 200 rpm for another 20 hours, and the yield of neopentyl glycol oleate was 96.7%.

Embodiment 3

[0035] The rapeseed oil methyl ester and trimethylolpropane (13.57g) that the molar ratio is 3.5:1 join in the rotary evaporator, and add the immobilized lipase Novozym 435 of 10% of the rapeseed oil methyl ester mass, and three Methylol propane quality 300% tert-butanol, the transesterification reaction is first carried out at 20KPa vacuum degree, 40°C, 200 rpm, and lasts for 8h; then, tert-butyl alcohol is distilled at 5KPa vacuum degree, 40°C temperature Alcohol; Secondly, the transesterification reaction was continued at 5KPa vacuum degree, 40°C, 200 rpm, and continued for another 24h, and the yield of trimethylolpropane rapeseed oil fatty acid ester was 92.3%.

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Abstract

The invention belongs to the technical field of biochemical industry, and relates to a novel process for synthesizing polyol ester by catalysis of lipase. The process is to catalyze an ester exchange reaction of fatty acid low alkanol ester and neopentyl polyol by immobilized lipase in the presence of an organic solvent to synthesize the polyol ester. Tertiary butyl alcohol is added into a reaction system to improve the solubility of substrate, so that the whole reaction system is in homogeneous (except immobilized enzyme), adverse effects of water on enzyme in catalytic activity and stability can also be completely eliminated, the reaction activity and stability of the immobilized lipase Novozym 435 and the immobilized lipase Lipozyme TL IM can be improved so as to remarkably improve the yield of the polyol ester. The fatty acid low alkanol ester adopted by the method can be selected from an alcoholysis product of natural animal and vegetable fat with methanol or ethanol, wherein the natural animal and vegetable fat has rich sources with low cost, and is a renewable resource. The renewable resource with wide sources as a raw material to synthesize the polyol ester has large market potential.

Description

technical field [0001] The invention relates to a new process for synthesizing polyol esters catalyzed by lipase, which belongs to the technical field of biochemical industry. technical background [0002] Most modern lubricating oils are composed of more than 86% base oil, plus various additives. The base oil is undoubtedly the decisive factor for the environmental or ecological impact of lubricants. With the development of modern industry and the increasing demand for environmental protection, synthetic esters as the base oil of high-performance lubricants have been more and more widely used because of their unique high and low temperature properties, viscosity-temperature properties, lubricating properties, and biodegradable properties. application. At present, it is not only used in the military field abroad, but also widely used in automobile, petrochemical, metallurgy, machinery and other industrial fields to make up for the defects of mineral oil in certain properti...

Claims

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Application Information

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IPC IPC(8): C07C67/03C07C69/675C12P7/42C10M105/40
Inventor 刘阳张利平
Owner 北京润华源天生物科技有限公司
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