Method for preparing hydroxyapatite/nano silver antimicrobial composite coating by pulse electrochemical deposition

A hydroxyapatite and nano-silver antibacterial technology, which is applied in the field of surface modification of medical biomaterials, can solve problems such as uneven distribution of silver and large particle size of silver particles

Inactive Publication Date: 2009-07-22
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods have some disadvantages, such as the large particle ...

Method used

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  • Method for preparing hydroxyapatite/nano silver antimicrobial composite coating by pulse electrochemical deposition
  • Method for preparing hydroxyapatite/nano silver antimicrobial composite coating by pulse electrochemical deposition
  • Method for preparing hydroxyapatite/nano silver antimicrobial composite coating by pulse electrochemical deposition

Examples

Experimental program
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Embodiment 1

[0027] (1) Take the titanium plate as the working electrode, and then acid and alkali surface treatment after conventional acetone ultrasonication.

[0028] (2) Dissolve 0.5g of silver nitrate in an appropriate amount of distilled water, and then slowly add 0.2g of cysteine;

[0029] (3) Take 0.394g of calcium nitrate tetrahydrate and 0.115g of ammonium dihydrogen phosphate, dissolve and mix them with distilled water, then slowly add (2) into it to prepare an electrolyte solution with a total volume of 1000ml of pH=4.0, and place the beaker Stir on a magnetic stirrer to obtain a uniform electrolyte;

[0030] (4) With the uniform electrolyte in (3), the saturated calomel electrode is used as the reference electrode, the platinum sheet is used as the counter electrode, and the biomedical metal to be coated is used as the working electrode. deposition. The relevant parameters are: pulse high potential: 0V, pulse low potential: -2.0V, pulse width: 100s, deposition time: 2h.

[...

Embodiment 2

[0051] The ammonium dihydrogen phosphate of embodiment 1 is changed into the NaH of equimolar concentration 2 PO 4 , for electrochemical deposition, other conditions remain unchanged.

Embodiment 3

[0053] The ammonium dihydrogen phosphate of embodiment 1 is changed into the KH of equimolar concentration 2 PO 4 , for electrochemical deposition, other conditions remain unchanged.

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Abstract

The invention discloses a method for preparing a hydroxyapatite/nano silver antibacterial composite coating through pulse electrochemical deposition, which comprises: using a calcium salt, phosphate, silver nitrate and a proper amount of coordination agent to prepare electrolyte with certain concentration and pH value, and performing electrodeposition in a electrolytic cell provided with a three-electrode system; taking a saturated calomel electrode as a reference electrode, a platinum sheet as a counter electrode and biological medical metal to be coated as a working electrode, wherein the pulse high electric potential is 0 volt, the pulse low electric potential is -2.0 volts, the pulse width is 100 seconds, and the deposition time is 2 hours; and depositing compositions in the coating on a base material in a mode of ions, uniformly dispersing nano silver generated during deposition in the composite coating, and finally preparing the hydroxyapatite/nano silver antibacterial compositecoating.

Description

Technical field [0001] The invention relates to a method for modifying the surface of a medical biomaterial, in particular to the preparation of a biometal material surface coating suitable for repairing human bone damage. Background technique [0002] Infection of biological materials is an important factor in surgical operations. The use of silver in biomaterials and medical devices has become an effective method of inhibiting bacteria. Silver and silver compounds have high antibacterial properties and can kill up to 16 types of bacteria, including Escherichia coli and Staphylococcus albus. Silver antimicrobial agents have received widespread attention due to their low toxicity to human cells, high thermal stability, and low volatility. The emergence of nano-silver makes the silver antibacterial agent show super antibacterial ability, and has become one of the hot spots in the research of biological antibacterial materials. Synthetic hydroxyapatite [HA, Ca 10 (PO 4 ) ...

Claims

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Application Information

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IPC IPC(8): A61L27/32A61L27/30A61L27/06A61L27/04
Inventor 鲁雄王英波周先礼张柏林冯波屈树新翁杰汪建新
Owner SOUTHWEST JIAOTONG UNIV
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