Water-insoluble medicine sustained-release pellet, sustained-release orally disintegrating tablet thereof and preparation method thereof

A technology of orally disintegrating tablets and sustained-release pellets, applied in the field of sustained-release pellets, can solve the problems of inability to achieve long-acting release, short slow release time, incomplete coating, etc., to maintain blood drug concentration, production steps Simple, selective effects
CN101862297AInactive Publication Date: 2010-10-20SHANGHAI INST OF PHARMA IND +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI INST OF PHARMA IND
Publication Date
2010-10-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a water-insoluble medicine sustained-release pellet, a sustained-release orally disintegrating tablet thereof and a preparation method thereof. The water-insoluble medicine sustained-release pellet comprises a hollow pellet core, a medicine layer, an insulation layer and a sustained-release layer, wherein the sustained-release layer comprises the following ingredients: 54 to 88 percent of sustained-release materials, 2 to 30 percent of antitackiness agents and 1 to 30 percent of pore-foaming agents, wherein the percentage is the mass percentage in the sustained-release layer, wherein the sustained-release materials are one kind or several kinds of materials selected from ethyl acrylate and methyl methacrylate copolymers, polyvinyl acetate and ethyl cellulose. Through regulating the coating combinations and filling auxiliary materials to be pressed into orally disintegrating tablets, the medicine can be slowly released for more than 8 to 13 hours, so the stable blood medicine concentration can be maintained, the side effect is reduced, the medicine taking times can be reduced, and the medicine taking is convenient. The invention conforms to zero-grade release, has the advantages of high final accumulated medicine release amount, high efficacy, strong selectivity, good mouth feeling, simple production steps and high efficiency, and can be applied to large-scale production.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, in particular to a water-insoluble sustained-release pellet, its sustained-release orally disintegrating tablet and a preparation method thereof. Background technique

[0002] The existing sustained-release preparations of water-insoluble drugs have a short slow-release time and cannot achieve long-acting release, the longest being only 6 hours. For example, ibuprofen sustained-release and fast-disintegrating tablets use phospholipids as blockers and Kollicoat SR 30D as coating material. The slow-release and fast-disintegrating tablets are prepared by granulation and coating process, but due to the limitation of granulation process, the coating is not complete. The sustained release time is only 1.5 hours (Fast dispersible / slow releasing ibuprofen tablets. Adamo Fini, Valentina Bergamante, Gian Carlo Ceschel, A. Fini et al. / European Journal of Pharmaceutics and Biopharmaceutics 69 (2008...

Claims

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