Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Porous magnesium alloy three-dimensional reinforced absorbable medical compound material and preparation method thereof

A composite material and porous magnesium technology, which is applied in the field of porous magnesium alloy three-dimensional reinforced absorbable medical composite materials, bone internal fixation composite materials, and orthopaedic internal fixation materials, which can solve the problem of reducing the ability of fracture fixation, unable to degrade and absorb, and affecting imaging examinations. Cancer patients with chemotherapy and other problems, to achieve the effect of improving toughness and overcoming too high and too strong acidity

Inactive Publication Date: 2012-04-04
SOUTHEAST UNIV
View PDF6 Cites 16 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Internal bone fixation is a routine method in orthopedic trauma surgery, bone defect repair surgery, and plastic surgery. Currently, internal fixation plates and screws are most commonly made of pure titanium or titanium alloy, which have stable fixation effects and superior biocompatibility. It provides a good internal environment for bone tissue healing, but it also has the following problems: (1) The elastic modulus of titanium metal is 8 times that of cortical bone, and it has a stress shielding effect on normal bone tissue, which is easy to cause osteoporosis and relapse Fracture; (2) It cannot be degraded and absorbed. If it is used for a long time, it will block X-rays and affect imaging examinations and chemotherapy for cancer patients.
[0006] However, the corrosion resistance of magnesium alloys is poor, and the biodegradation rate in the human body is too fast, and the corrosion is often serious before the fracture fixation and healing are not completely stable, and the excessive corrosion degradation rate will cause a significant decrease in mechanical strength and reduce the fracture fixation rate. ability, and the rapid and large release of magnesium metal ions can cause bone dissolution
Although there are also research reports on improving its corrosion resistance through surface modification, the results are not ideal.
[0007] Therefore, in order to solve the above-mentioned existing problems, a kind of bone internal fixation composite material prepared by the present invention is composed of absorbable porous magnesium alloy three-dimensional structure as a reinforcement and polylactic acid as a matrix. Materials and biodegradable magnesium alloys have their respective advantages, but at the same time they can overcome their respective shortcomings. They have good application prospects in orthopedic trauma surgery, bone defect repair surgery, plastic surgery, especially in internal fixation of high-stress fractures. , but so far there have been no relevant research reports at home and abroad

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Porous magnesium alloy three-dimensional reinforced absorbable medical compound material and preparation method thereof
  • Porous magnesium alloy three-dimensional reinforced absorbable medical compound material and preparation method thereof
  • Porous magnesium alloy three-dimensional reinforced absorbable medical compound material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 5g of AZ31B porous magnesium alloy reinforcement with a porosity of 50% was prepared by powder metallurgy molding method, and 10g / L sodium silicate, 2g / L NaOH and 10g / L hydroxyapatite nanoparticles were used as micro-arc oxidation electrolysis In the liquid system, the magnesium alloy reinforcement is immersed in it and a voltage of 400V is applied for 20 minutes of micro-arc oxidation treatment to form a ceramic protective film rich in magnesium oxide, magnesium silicate and hydroxyapatite on the surface in situ. Take 6g of polylactic acid with a molecular weight of 200,000, heat it to 220°C and melt it, inject it into the cavity of a cube mold with a side length of 20mm, mix and stir the polylactic acid solution with the porous magnesium alloy structure evenly, so that the pores in the porous magnesium alloy will be filled. Filled with polylactic acid solution, vacuum dried at 90°C for later use. Then press at 170° C. and 10 MPa for 20 minutes, and cool to room temper...

Embodiment 2

[0041] Using the die-casting molding process, prepare a "king"-shaped three-dimensional magnesium alloy frame reinforcement 2.3g composed of support rods, and pass it through the micro-arc oxidation treatment method as shown in Example 1 to obtain magnesium oxide-rich , magnesium silicate, hydroxyapatite film layer. The three-dimensional porous magnesium alloy frame reinforcement is placed in a 20mmx40mmx5mm die cavity and fixed. Take 4.8g of polylactic acid with a molecular weight of 200,000, and directly mix the polylactic acid powder with the three-dimensional porous magnesium alloy frame reinforcement, so that the three-dimensional porous magnesium alloy frame is evenly filled with polylactic acid powder, and set aside. The mixture was molded at 200° C. under 10 MPa pressure for 10 minutes, and cooled to normal temperature. Finally, it can be machined into the required internal fixation products for orthopedics.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
elastic modulusaaaaaaaaaa
densityaaaaaaaaaa
Login to View More

Abstract

The invention discloses a porous magnesium alloy three-dimensional reinforced absorbable medical compound material and a preparation method thereof. The compound material is prepared by compounding a porous magnesium alloy structural member which has a three-dimensional mesh structure and serves as a reinforcing body and absorbable high polymer material polylactic acid which is compounded and filled into the holes of the porous magnesium alloy reinforcing body and serves as a substrate. Degradable polymer substrates such as polylactic acid and the like are mixed with the wild phase of the porous magnesium alloy structural member, are molded or extruded into bars or plates under certain pressures, and are treated with subsequent machining, so that various degradable biological medical compound materials can be obtained. The method has the characteristics of mild processing condition and easiness for operating; the product has high mechanical performance, high biocompatibility and wide application prospect, and is suitable for orthopedic internal fixation products of various shapes; the production degradation is safe, stable and controllable; and the pain to a patient caused by secondary operation or advanced invalidation of the conventional orthopedic product is avoided.

Description

technical field [0001] The invention relates to an orthopedic internal fixation material in medical equipment, belongs to the field of biomedical equipment, and is particularly suitable for the fields of orthopedic trauma surgery, bone defect repair surgery, and medical equipment for plastic surgery. Specifically, it is a porous magnesium alloy three-dimensional reinforced absorbable medical composite material, which is a bone internal fixation composite material formed by compounding a porous magnesium alloy three-dimensional structural part reinforcement with absorbability and a polylactic acid matrix. Background technique [0002] Internal bone fixation is a routine method in orthopedic trauma surgery, bone defect repair surgery, and plastic surgery. Currently, internal fixation plates and screws are most commonly made of pure titanium or titanium alloy, which have stable fixation effects and superior biocompatibility. It provides a good internal environment for bone tiss...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/14
Inventor 储成林薛烽韩啸董寅生白晶郭超盛晓波王世栋
Owner SOUTHEAST UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com