Medicine sustained release nanofiber membrane for treating periodontitis and preparation method for medicine sustained release nanofiber membrane

A nanofiber film and periodontitis technology, applied in the field of sustained-release nanofiber film for the treatment of periodontitis and its preparation, can solve the problems of difficult degradation of hydroxyapatite, difficulty in sustained release, difficulty in cell adhesion, etc., and achieve Good biodegradability and biocompatibility, achieving slow release and avoiding secondary infection

Inactive Publication Date: 2012-04-25
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the hydroxyapatite in the film layer is difficult to degrade, and only briefly mentions the drug sustained release function of metronidazole
[0005] Although biodegradable periodontal regeneration sheets have been clinically applied, there are still some problems to be solved, such as the poor mechanical properties and strong hydrophobicity of pure biodegradable polymers, which easily lead to material collapse and difficult cell adhesion; When the drug is passed through the coating process or the hydrophobic polymer is used as the carrier, the drug is often enriched on the surface of the material, which is prone to early "burst release" of the drug and is difficult to release continuously

Method used

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  • Medicine sustained release nanofiber membrane for treating periodontitis and preparation method for medicine sustained release nanofiber membrane
  • Medicine sustained release nanofiber membrane for treating periodontitis and preparation method for medicine sustained release nanofiber membrane
  • Medicine sustained release nanofiber membrane for treating periodontitis and preparation method for medicine sustained release nanofiber membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Slowly add the cellulose nanocrystals dispersed in N,N-dimethylformyl into the chloroform solution of polyhydroxybutyrate valerate (PHBV) while stirring, wherein the PHBV and CNCs in the mixed solution The sum of the mass fractions is 9%, the mass ratio of PHBV to CNCs is 9:1, and the mass ratio of N,N-dimethylformamide to chloroform is 1:8;

[0034] (2) The mixed solution is heated up to 70° C., fully stirred and swollen, and cooled down to room temperature after being mixed uniformly; then tetracycline hydrochloride is added to the mixed solution, wherein the quality of tetracycline hydrochloride is 5% of the total mass of PHBV and CNCs, to obtain Stable and uniform electrospinning stock solution;

[0035] (3) Electrospinning the above-mentioned spinning solution prepared under the spinning conditions that the inner diameter of the needle tube is 0.7mm, the flow rate is 1.8mL / h, the voltage is 15kV and the receiving distance is 16cm, and collected by a flat electr...

Embodiment 2

[0038] (1) Slowly add the cellulose nanocrystals dispersed in N,N-dimethylacetamide into the chloroform solution of polylactic acid (PLA) while stirring, wherein the sum of the mass fractions of PLA and CNCs in the mixed solution is 16%, the mass ratio of PLA to CNCs is 5:1, and the mass ratio of N,N-dimethylacetamide to chloroform is 1:7;

[0039] (2) Raise the temperature of the mixed solution to 60°C, fully stir and swell, and cool down to room temperature after mixing evenly; then add minocycline hydrochloride to the mixed solution, wherein the quality of minocycline hydrochloride is the total of PLA and CNCs 10% of the mass to obtain a stable and uniform electrospinning dope;

[0040] (3) Electrospin the spinning solution prepared above under the spinning conditions of 0.7mm inner diameter of the needle tube, 1.5mL / h flow rate, 15kV voltage and 18cm receiving distance, and collect it by a rotating drum. The above product was vacuum-dried at room temperature for 20 h to o...

Embodiment 3

[0043] (1) Slowly add cellulose nanocrystals dispersed in tetrahydrofuran into an acetone solution of poly(lactic acid-glycolic acid) copolymer (PLGA) while stirring, wherein the sum of the mass fractions of PLGA and CNCs in the mixed solution is 7 %, the mass ratio of PLGA and CNCs is 49:1, and the mass ratio of THF and acetone is 1:2;

[0044] (2) Warm up the mixed solution to 58°C, fully stir and swell, and cool down to room temperature after mixing evenly; then add metronidazole benzoic acid into the mixed solution, wherein the mass of metronidazole benzoic acid is the total of PLGA and CNCs 19% of the mass, to obtain a stable and uniform electrospinning dope;

[0045] (3) Electrospin the spinning solution prepared above under the spinning conditions of 0.7mm inner diameter of the needle tube, 1.0mL / h flow rate, 12kV voltage and 14cm receiving distance, and collect it with a rotating drum. The above product was vacuum-dried at room temperature for 15 hours to obtain a dru...

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Abstract

The invention relates to a medicine sustained release nanofiber membrane for treating periodontitis and a preparation method for the medicine sustained release nanofiber membrane. The nanofiber membrane comprises biodegradable polymer, cellulose nanocrystals and an active medicine, wherein the mass ratio of the biodegradable polymer to the cellulose nanocrystals is (4-99):1; and the actual loading capacity of the active medicine of the nanofiber membrane is 10 to 500mu g / mg. The preparation method for the medicine sustained release nanofiber membrane comprises the following steps of: (1) adding the cellulose nanocrystals which are dispersed in an organic solvent A into an organic solution B of the biodegradable polymer with stirring to obtain mixed liquid; (2) adding the active medicine into the mixed liquid to obtain an electrostatic spinning stock solution; and (3) performing electrostatic spinning on the electrostatic spinning stock solution, drying a product, and thus obtaining the nanofiber membrane. The preparation process is simple, quick, cheap and efficient, and is suitable for industrialized batch production; and the obtained nanofiber membrane has high biocompatibility, high medicine loading capacity, appropriate hydrophillic performance and a broad application prospect, and the sustained release of the active medicine is slow.

Description

technical field [0001] The invention belongs to the field of electrospinning drug sustained-release nanofiber membrane and its preparation, in particular to a drug sustained-release nanofiber membrane for treating periodontitis and a preparation method thereof. Background technique [0002] Periodontitis has been considered as the "number one killer" of oral health by medical definitions, and it is also known as the third killer that threatens human health after cancer and cardiovascular and cerebrovascular diseases. The prevalence rate of oral diseases in our country has been as high as 97.6%, and many people are enduring the pain of oral diseases. According to research, oral diseases are mainly caused by direct or indirect infection of periodontal tissue, so the treatment of periodontitis is urgent for our country and even the world. Periodontal disease is a chronic destructive disease of the periodontal tissue caused by dental plaque. If it is not treated effectively, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/16D01F6/92D01F1/10D01D1/02D01D5/00D04H1/435
Inventor 秦宗益余厚咏田菲
Owner DONGHUA UNIV
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