Temperature-sensitive block copolymer and its hydrogel as well as application
A technology of block copolymers and copolymers, applied in the fields of application, animal cells, food science, etc., to achieve the effects of high purity, easy operation and controllable properties
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[0032] Example 1: Synthesis of poly(2-ethyl-2-oxazoline)-polylactic acid-poly(2-ethyl-2-oxazoline) (PEOz1000-PLA2300-PEOz1000)
[0033] In a three-necked flask equipped with a stirrer, add 2-ethyl-2-oxazoline (10g, 150mmol), acetonitrile (40mL), and methyl p-toluenesulfonate (0.47g) at an oil bath temperature of 80°C. Under nitrogen atmosphere, the reaction was stirred for 30h. After cooling, the methanol solution of KOH was added, and the reaction was continued for 4 hours. The solvent was removed, the residue was dissolved in THF, passed through a silica gel column, and the effluent was poured into excess cold ether for precipitation, suction filtration, and vacuum drying for 12 hours. The obtained PEOz-OH powder (4g) was dissolved in chlorobenzene (80mL), D,L-lactide (6.3g) and stannous octoate (0.63g) were added under nitrogen atmosphere, and reacted at 140°C for 24h. The reaction solution was poured into excess ether for precipitation, filtered, and vacuum dried at room te...
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[0034] Example 2: Synthesis of poly(2-methyl-2-oxazoline)-polycaprolactone-poly(2-methyl-2-oxazoline) (PMOz1200-PCL2000-PMOz1200)
[0035] In a three-necked flask equipped with a stirrer, add 2-methyl-2-oxazoline (15g), acetonitrile (40mL), and methyl p-toluenesulfonate (0.47g). At an oil bath temperature of 80°C, The reaction was stirred under nitrogen atmosphere for 30h. After cooling, the methanol solution of KOH was added, and the reaction was continued for 4 hours. The solvent was removed, the residue was dissolved in THF, passed through a silica gel column, and the effluent was poured into excess cold ether for precipitation, suction filtration, and vacuum drying for 12 hours. The obtained PMOz-OH powder (0.47g) was dissolved in chlorobenzene (40mL), caprolactone (0.47g) and stannous octoate (0.47g) were added under nitrogen atmosphere, and reacted at 140°C for 24h. The reaction solution was poured into excess ether for precipitation, filtered, and vacuum dried at room te...
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[0036] Example 3: Synthesis of polylactic acid-poly(2-ethyl-2-oxazoline)-polylactic acid (PLA900-PEOz3000-PLA900)
[0037] Dissolve 2-ethyl-2-oxazoline (9.9g) and 1,4-dibromo-2-butene (420mg) in acetone (40mL), and under nitrogen atmosphere at 100°C (stir and reflux for 20h. Cool. After reaching room temperature, add 0.1 mol / L KOH methanol solution (40 mL) to the reaction flask, and continue the reaction for 4 hours. Pass through a silica gel column, pour the effluent into excess cold ether for precipitation, suction filtration, and vacuum dry for 24 hours. HO-PEOz-OH powder (2g) was dissolved in chlorobenzene (20mL), D,L-lactide (0.58g) and stannous octoate (30mg) were added under nitrogen atmosphere, and reacted at 140°C for 24h. The reaction solution was poured into excess ether for precipitation, filtered, and vacuum dried at room temperature for 12 hours to obtain the triblock copolymer PLA900-PEOz3000-PLA900 of the present invention.
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