Surface modified medical metal material and preparation method thereof

A metal material and surface modification technology, applied in the field of surface-modified medical metal materials and their preparation, can solve the problem of weak bonding strength between hydroxyapatite coating and titanium-based metal materials, shortening of implant life, and implantation. The failure of bulk materials, etc., to achieve the effect of good biocompatibility and activity, low production cost and high density

Inactive Publication Date: 2013-02-06
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Although these methods can improve the biocompatibility and antibacterial properties of medical titanium or magnesium metal materials, they generally have the problem of weak bonding strength between hydroxyapatite coating and titanium-based metal materials.
It is generally believed that as a bone tissue implant material, in addition to the need to replace it due to infection after implantation in clinical applications, it may also be due to the partial peeling off of the coating and the Dissolution, etc., lead to failure of the coating, shorten the life of the implant, and cause the failure of the implant material; the main reason for this problem is the interaction between the interface between the coating and the matrix or the interface between the coating and the bone tissue
At present, most studies on the interface behavior of the bone-coating-matrix system focus on the microstructure, bonding strength and tissue response of the interface between the bone and the coating; how to improve the hydroxyapatite coating There are relatively few studies on the interface bonding strength between layers and substrates

Method used

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  • Surface modified medical metal material and preparation method thereof
  • Surface modified medical metal material and preparation method thereof
  • Surface modified medical metal material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031](1) Place a 10mm×10mm×1mm pure titanium sheet in acetone, ethanol, and deionized water for 10 minutes to obtain a pure titanium sheet with a clean surface; control the temperature of the piranha solution at 95°C, and add the pure titanium sheet with a clean surface sheet, oxidized for 20min to obtain surface oxidized titanium sheet;

[0032] (2) Put the above surface oxidized titanium sheet in 1000mL of toluene, add 2mL of silane coupling agent γ-methacryloxypropyltrimethoxysilane, stop the reaction after refluxing for 15h, take out the titanium sheet, and let it dry naturally Dry to obtain γ-methacryloxypropyltrimethoxysilane-coupled titanium sheets;

[0033] (3) Then put the pure titanium sheet coupled with γ-methacryloxypropyltrimethoxysilane in 250mL of methanol, and add 50mL of vinylpyrrolidone, 1g of azobisisobutyl Nitrile, stop the reaction after reflux reaction for 15 hours, take out the titanium sheet, and dry naturally; the medical titanium metal material graf...

Embodiment 2

[0035] (1) Place a 10mm×10mm×1mm pure titanium sheet in acetone, ethanol, and deionized water for 10 minutes to obtain a pure titanium sheet with a clean surface; control the temperature of the piranha solution at 80°C, and add the pure titanium sheet with a clean surface sheet, oxidized for 40min to obtain surface oxidized titanium sheet;

[0036] (2) Put the above surface oxidized titanium sheet in 1000mL of toluene, add 2mL of silane coupling agent γ-methacryloxypropyltrimethoxysilane, stop the reaction after refluxing for 15h, take out the titanium sheet, and let it dry naturally Dry to obtain γ-methacryloxypropyltrimethoxysilane-coupled titanium sheets;

[0037] (3) Then put the titanium plate coupled with γ-methacryloxypropyltrimethoxysilane in 250mL of methanol, and add 30mL of vinylpyrrolidone and 1g of azobisisobutyronitrile in sequence under nitrogen atmosphere , stop the reaction after 15 hours of reflux reaction, take out the pure titanium sheet, and let it dry na...

Embodiment 3

[0039] (1) Place a 10mm×10mm×1mm pure titanium sheet in acetone, ethanol, and deionized water for 10 minutes in order to obtain a pure titanium sheet with a clean surface; control the temperature of the piranha solution at 90°C, and add the pure titanium sheet with a clean surface sheet, oxidized for 20min to obtain surface oxidized titanium sheet;

[0040] (2) Put the above surface oxidized titanium sheet in 1000mL of toluene, add 2mL of silane coupling agent γ-methacryloxypropyltrimethoxysilane, stop the reaction after refluxing for 15h, take out the titanium sheet, and let it dry naturally Dry to obtain γ-methacryloxypropyltrimethoxysilane-coupled titanium sheets;

[0041] (3) Then put the titanium plate coupled with γ-methacryloxypropyltrimethoxysilane in 250mL of methanol, and add 50mL of vinylpyrrolidone and 1g of azobisisobutyronitrile in sequence under nitrogen atmosphere , stop the reaction after reflux reaction for 15 hours, take out the titanium sheet, and dry natu...

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Abstract

The invention discloses a surface modified medical metal material (titanium, titanium alloy, magnesium and magnesium alloy) and a preparation method of the surface modified medical metal material. Medical metal is firstly oxidized in a piranha solution, and an oxide layer is formed on the metal surface; a coupling reagent is used for coupling, and double bonds are led on the surface in a covalence mode; and finally a free radical polymerization method is adopted to cause copolymerization between the medical metal and vinylpyrrolidone monomers so as to lead in polyvinylpyrrolidone macromolecules on the surface of the medical metal in a covalence mode. A surface modified layer of the medical metal material is located on the oxide layer of the medical metal surface, and thickness of the modified layer is located in a micron scale. After the surface modified layer absorbs silver ions, the surface modified layer has a good antibiosis capability on escherichia coli and staphylococcus aureus, and antibiosis rate can achieve higher than 98%. The surface modified medical metal material prepared by the method has a good biological activity, stability and an antibacterial property and is simple in preparation method, free of needs of special equipment, low in production cost and applicable to industrial production.

Description

technical field [0001] The present invention relates to a surface-modified medical metal material and a preparation method thereof; in particular to a method of chemically covalently grafting polyvinylpyrrolidone to modify the surface of medical metal so as to endow the medical metal material with good biological activity and phase Capacitance and antibacterial properties belong to the technical field of surface modification of metal materials. Background technique [0002] The research on the treatment of bone defect and bone repair is still a big problem in the field of orthopedics. Since the number of autologous bone is limited and autologous bone transplantation will increase infection, it is impossible to completely use autologous bone for repair, and the transplantation of allogeneic bone (human bone, animal bone, etc.) has problems such as immune response. It is of great practical significance to provide artificial bone substitute materials with good performance, whi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C22/00A61L27/28
Inventor 彭淑鸽樊昕洁祝迎春
Owner HENAN UNIV OF SCI & TECH
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