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Antimicrobial peptide freeze-dried preparation for treating colpitis and preparation method thereof

A freeze-dried preparation and antibacterial peptide technology, applied in the medical field, can solve the problems of insignificant drug treatment effect, incomplete treatment, bacterial resistance, etc., and achieve the effect of accelerating wound healing process, protecting physical and mental health, and strong killing effect.

Inactive Publication Date: 2014-09-17
广州舒泰生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many drugs on the market to treat diseases, the general drug treatment effect is not significant, and basically there will be incomplete treatment and rebound phenomenon
It has caused a lot of inconvenience to the life and work of patients, and it has also had a great impact on their physical and mental health. However, many drugs now have bacterial resistance problems

Method used

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  • Antimicrobial peptide freeze-dried preparation for treating colpitis and preparation method thereof
  • Antimicrobial peptide freeze-dried preparation for treating colpitis and preparation method thereof
  • Antimicrobial peptide freeze-dried preparation for treating colpitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The freeze-dried powder is configured as follows: Weigh 50g of antimicrobial peptide human beta defensin, 5g of low molecular weight heparin sodium, 600g of stabilizer, add 10000ml of injection grade water, mix well, filter and sterilize, fill in 3.2ml of vials and half-stopper Then put it into a vacuum freeze dryer and freeze-dry for 15 hours. The process conditions of vacuum freeze-drying are as follows: pre-freeze the product, lower the temperature to -50°C, cool down for 4 hours, evacuate to 0.3mbar, heat and sublimate and dry for 15 hours, until the water in the product is completely sublimated .

[0031] Wherein the stabilizer formula is: 200g glycine, 300g protein hydrolyzate, 100g (10mM) phosphoric acid.

[0032] The configuration of basic liquid of the present invention is:

[0033] Basic liquid formula:

[0034]

[0035]

[0036] After the above formula is dissolved, it is sterilized by filtration, filled and capped in 15ml / bottle. When in use, the a...

Embodiment 2

[0038] Freeze-dried powder of the present invention is configured as:

[0039] Weigh 80g of antimicrobial peptide human beta defensin, 8g of low molecular weight heparin sodium, 500g of stabilizer, add 10000ml of water for injection, mix evenly, filter and sterilize, fill in 3.2ml of vials with a half-stopper and put them into vacuum freeze-drying Freeze-dried on the machine for 25 hours. The process conditions of vacuum freeze-drying are: pre-freeze the product, lower the temperature to -50°C, cool down for 6 hours, vacuumize to 0.3mbar, heat and sublimate and dry for 20 hours, until the water in the product sublimates completely .

[0040] Wherein the stabilizer formula is: 150g trehalose, 200g sodium thiosulfate, 150g (15mM) sodium carbonate

[0041] The configuration of basic liquid in the present embodiment is:

[0042] Basic liquid formula:

[0043]

[0044] After the above formula is dissolved, it is sterilized by filtration, filled and capped in 15ml / bottle. Wh...

Embodiment 3

[0046] Freeze-dried powder of the present invention is configured as:

[0047] Weigh 100g of antimicrobial peptide, 5g of low molecular weight heparin sodium, 500g of stabilizer, add 10000ml of water for injection, mix evenly, filter and sterilize, fill in 3.2ml in a vial and put it in a vacuum freeze dryer for 35 hours with a stopper. . The process conditions of vacuum freeze-drying are: pre-freeze the product, lower the temperature to -50°C, cool down for 8 hours, vacuumize to 0.3mbar, heat and sublimate and dry for 25 hours, until the water in the product sublimates completely .

[0048] Wherein the stabilizer formula is: 200g sucrose, 200g vitamin D, 100g (10mM) potassium citrate

[0049] The configuration of the basic liquid in this embodiment is:

[0050] Basic liquid formula:

[0051]

[0052]After the above formula is dissolved, it is sterilized by filtration, filled and capped in 15ml / bottle. When in use, the antimicrobial peptide freeze-dried powder of the pr...

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Abstract

The invention provides a freeze-dried preparation for treating colpitis. The preparation includes an antimicrobial peptide freeze-dried powder and an antibacterial peptide basic liquid. The antibacterial peptide freeze-dried powder comprises the following components according to the total mass percentage: 0.1%-8% of an antibacterial peptide human beta defensin, 0.01%-0.2% of a low molecular weight heparin sodium and 1%-15% of a stabilizing agent; the antibacterial peptide basic liquid comprises the following components according to the total mass percentage: 0.01%-0.4% of hyaluronic acid, 0.5%-4% of menthoxypropanediol, 0.5%-5% of a honey extract, 0.5%-5% of PCA sodium, 0.5%-5% of dissolved protease, 0.3%-0.7% of 1,2 hexanediol, 1.5%-6% of oat beta dextran, 1%-5% soybean isoflavone, and the balance of deionized water or water for injection. The antimicrobial peptide freeze-dried preparation provided by the invention has broad-spectrum antibacterial activity, and strong killing effect on bacteria, fungi, viruses, protozoa and cancer cells, and even can enhance immunity, accelerate wound healing process; in addition, the preparation has obvious curative effect, and no rebound or side effect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an antibacterial peptide freeze-dried preparation for treating women's vaginitis and a preparation method thereof. Background technique [0002] Human defensins are widely distributed in the female reproductive tract, and are closely related to the defense mechanism of female natural immunity. It plays an important role in ensuring that the female reproductive system maintains reproductive health in a normal state and resists various exogenous bacterial infections. Under normal circumstances, there are many kinds of microorganisms in the vagina of women. These microorganisms maintain the physiological state of the reproductive tract without infection. also play an important role. [0003] In today's society, due to many reasons such as environmental pollution and accelerated pace of life, the prevalence of gynecological diseases is getting higher and higher, and the age range is gradu...

Claims

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Application Information

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IPC IPC(8): A61K38/00A61P15/02A61P17/04A61P15/00A61K31/727
Inventor 张晏万宇余少娜陈凡
Owner 广州舒泰生物技术有限公司
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