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Compound topical cream and application thereof

A topical, cream technology, applied in the directions of ointment delivery, pharmaceutical formulation, emulsion delivery, etc., can solve the problems of high treatment cost and poor curative effect, and achieve the effect of improving quality of life, fast onset, and improving stability

Inactive Publication Date: 2015-04-08
HEFEI YIFAN PHARMA MANAGEMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment principles of western medicine for herpes zoster are anti-virus, anti-inflammatory, pain-relieving and prevention of secondary infection, which has a certain relieving effect, but there are problems of high treatment cost and poor curative effect

Method used

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  • Compound topical cream and application thereof
  • Compound topical cream and application thereof
  • Compound topical cream and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Prepare the compound topical cream according to the following formula:

[0046]

[0047] The preparation method is as follows:

[0048] Add phthalobutane into dimethyl sulfoxide water bath and heat to dissolve, set aside;

[0049] Put cetostearyl alcohol, liquid paraffin, and glyceryl monostearate into the oil phase dissolving pot respectively, heat to 80°C and keep warm for 30 minutes. spare;

[0050] Put propylene glycol and purified water into the water phase dissolving pot and heat it to 80°C for 30 minutes, then put polysorbate 80, sodium lauryl sulfate and lidocaine into the water phase dissolving pot until they are completely dissolved to obtain Water phase, keep warm for standby;

[0051] Pass the water phase and the oil phase through a 200-mesh sieve under negative pressure and suck them into the vacuum emulsification pot successively; then add the dimethyl sulfoxide solution of phthalobutanol into the vacuum emulsification pot, keep emulsification at 80°...

Embodiment 2

[0053] Prepare the compound topical cream according to the following formula:

[0054]

[0055] The preparation method is as follows:

[0056] Add phthalobutane to a lauryl alcohol water bath and heat to dissolve, set aside;

[0057] Put glyceryl monostearate, polysorbate 80, and isopropanol into the oil phase dissolving pot respectively, heat to 80°C and keep warm for 30 minutes. After the heat preservation is over, add benzyl alcohol until completely dissolved to obtain the oil phase, keep warm for later use;

[0058] Put linoleic acid and purified water into the water phase dissolving pot and heat it to 80°C for 30 minutes, then put sodium lauryl sulfate and lidocaine into the water phase dissolving pot until completely dissolved to obtain the water phase, keep it warm for later use ;

[0059] Pass the water phase and the oil phase through a 200-mesh sieve under negative pressure and suck them into the vacuum emulsification pot successively; then add the lauryl alcohol...

Embodiment 3

[0061] Prepare the compound topical cream according to the following formula:

[0062]

[0063] The preparation method is as follows:

[0064] Add phthalobutane into dimethyl sulfoxide water bath and heat to dissolve, set aside;

[0065] Put menthol, oleic acid, and sodium lauryl sulfate into the oil phase dissolving pot respectively, heat to 80°C and keep warm for 30 minutes. After the heat preservation is over, add sodium benzoate until completely dissolved to obtain the oil phase, keep warm for later use;

[0066] Put ethanol and purified water into the water-phase dissolving pot and heat it to 80°C for 30 minutes, then put polysorbate 80, sodium lauryl sulfate and lidocaine into the water-phase dissolving pot until completely dissolved to obtain Water phase, keep warm for standby;

[0067] Pass the water phase and the oil phase through a 200-mesh sieve under negative pressure and suck them into the vacuum emulsification pot successively; then add the dimethyl sulfoxid...

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Abstract

The invention belongs to the field of topical medicines and particularly relates to a compound topical cream and application thereof. The compound topical cream is mainly prepared from ftibamzone, lidocaine or an acceptable pharmaceutical salt thereof and a pharmaceutically acceptable excipient. The long-term practice of the inventor shows that ftibamzone and lidocaine can be used together for resisting herpes virus and relieving pain, can take effect quickly and can act synergistically to achieve an unexpected effect. The compound topical cream provided by the invention can be used for resisting herpes virus, relieving pain and itching and treating herpes simplex and herpes zoster effectively and has the functions of alleviating pain, astringing, protecting, diminishing inflammation, preventing anabrosis and reddening and resisting irritation. In addition, the compound topical cream can improve the stability of ftibamzone, can be well absorbed by a human body, can take effect quickly, can ensure that wounds scab quickly, can reduce the suffering of patients, has a strong pain relieving effect, a high cure rate, a significant treatment effect and a little side effects, is convenient to use and is safe and simple.

Description

technical field [0001] The invention relates to the field of topical medication, in particular to a compound topical cream and its application. Background technique [0002] Viral infection causes various diseases and seriously threatens people's health. Therefore, viral infection has always been a serious social topic that people care about. Viral skin diseases occupy an important position in skin disease patients, and herpes zoster is an acute infectious skin disease caused by varicella-zoster virus. Herpes zoster virus invades through the sensory nerve endings of the skin and enters the neurons of the ganglion cells in the dorsal roots of the spinal nerves, where it remains dormant. When the body's immunity is weakened, the virus is activated and multiplied, causing inflammation and necrosis of the affected neurons and the skin of the innervated area, resulting in pain and staged herpes. Its main features are clusters of blisters distributed along one side of the periph...

Claims

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Application Information

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IPC IPC(8): A61K31/4035A61K9/06A61P31/22A61K31/167
CPCA61K31/4035A61K9/06A61K31/167A61K2300/00
Inventor 周文艳李晓祥程先锋张艾忠
Owner HEFEI YIFAN PHARMA MANAGEMENT
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