Method for synthesizing aromaticnitrile
An aromatic nitrile and compound technology, which is applied in the field of synthesizing aromatic nitrile compounds, can solve the problems of serious environmental pollution, harsh reaction conditions, high toxicity of cyanide source, etc., and achieves the effects of safe and simple operation, easy availability and low price.
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Embodiment 1
[0044]Add 0.3 mmol 4-biphenylboronic acid, 0.6 mmol 2-cyano-3-ethoxy ethyl acrylate, 0.3 mmol cuprous iodide, 2 ml N,N-dimethylformamide to the reaction flask , 0.3 millimoles of tert-butanol peroxide, in the air atmosphere, 130 ° C stirring reaction for 24 hours, stop heating and stirring, cooled to room temperature, vacuum distillation to obtain the crude product, and then separated and purified by column chromatography to obtain the target product , the column chromatography eluent used is a mixed solvent of petroleum ether and ethyl acetate, wherein the volume ratio between petroleum ether and ethyl acetate is 20:1, and the yield is 72%.
Embodiment 2
[0046] Add 0.3 mmol 4-biphenylboronic acid, 0.6 mmol 2-cyano-3-ethoxy ethyl acrylate, 0.3 mmol cuprous iodide, 2 ml N,N-dimethylformamide to the reaction flask , 0.3 millimoles of tert-butanol peroxide, in the air atmosphere, 100 ° C stirring reaction for 24 hours, stop heating and stirring, cooled to room temperature, vacuum distillation to obtain the crude product, and then separated and purified by column chromatography to obtain the target product , the column chromatography eluent used is a mixed solvent of petroleum ether and ethyl acetate, wherein the volume ratio between petroleum ether and ethyl acetate is 20:1, and the yield is 30%.
Embodiment 3
[0048] Add 0.3 mmol 4-biphenylboronic acid, 0.6 mmol 2-cyano-3-ethoxy ethyl acrylate, 0.3 mmol cuprous iodide, 2 ml N,N-dimethylformamide to the reaction flask , 0.3 millimoles of tert-butanol peroxide, under air atmosphere, 120 ° C stirring reaction for 24 hours, stop heating and stirring, cooled to room temperature, vacuum distillation to obtain the crude product, and then separated and purified by column chromatography to obtain the target product , the column chromatography eluent used is a mixed solvent of petroleum ether and ethyl acetate, wherein the volume ratio between petroleum ether and ethyl acetate is 20:1, and the yield is 52%.
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