Preparation method of porous hydroxyapatite and strontium oxide composite bone repair material

Abstract

The invention relates to a preparation method of a porous hydroxyapatite and strontium oxide composite bone repair material, and belongs to the technical field of biomedical material preparation. The method comprises the steps that 88%-99% by mass of hydroxyapatite and 12%-1% by mass of strontium oxide ceramic powder are weighed and ball-milled, and mixed powder is obtained; 40%-70% by mass of the mixed powder and 60%-30% by mass of ammonium bicarbonate pore-forming agent powder are mixed to be uniform and mechanically pressed into a block pressed blank; the pressed blank is put into a graphite mold, then the graphite mold is put into a discharging plasma sintering furnace for sintering, the sintered mold is naturally cooled to room temperature along with the furnace, demolding is conducted, and the porous hydroxyapatite and strontium oxide composite bone repair material is obtained. According to the porous hydroxyapatite and strontium oxide composite bone repair material prepared through the preparation method, any binding agent and templating agent do not need to be added, the components are pure, harmful impurities do not exist, the porosity is controllable between 20% and 50%, the degradation rate is appropriate, good osteogenic induction capacity is achieved, the technology is simple and easy to carry out, and the porous hydroxyapatite and strontium oxide composite bone repair material can be used for a bone defect repair material for hard tissue regeneration or reconstruction of organisms.

Description

technical field [0001] The invention relates to a preparation method of a porous hydroxyapatite / strontium oxide composite bone repair material, belonging to the technical field of preparation of biomedical materials. Background technique [0002] In the clinical medical process, it is often encountered in the reconstruction or regeneration of bone defects caused by disease or trauma, which requires a large number of bone defect repair materials. At present, the most widely used bone defect repair materials in clinical practice are autologous bone and allogeneic bone. Among them, autologous bone is the most ideal material for bone defect repair, but there are problems such as insufficient sources and complications in the donor area, which limit its application; and Allograft bone has problems such as graft rejection, disease transmission, and long fusion time. Therefore, there is a need to research and develop new artificial bone repair materials to meet a large number of cl...

AI Technical Summary

Problems solved by technology

However, the above method has the following problems: (1) In order to improve the mechanical properties of the material and obtain a stable porous structure, the preparation process of the above method often requires a long-term high-temperature sintering process for the material

Excessively high sintering temperature and long holding time will cause partial decomposition of HA. Because the decomposition products of HA are inconsistent with the degradation rate of HA, the degradation rate of the material does not match the crawling replacement rate of bone tissue, resulting in bone defects of the material. (2) In the process of preparing materials by the above method, binders (such as polyvinyl alcohol, sodium silicate, etc.) need to be added. Although most of the binders will decompose and volatilize during high-temperature sintering, there are still A small amount of binder remains in the material

These residual binders such as sodium silicate will not degrade, will affect the ingrowth of microvessels and bone tissue, and reduce the biocompatibility and osteogenic activity of the material, while polyvinyl alcohol has been proved to be toxic to liver and gallbladder tissue; (3) The above method is easy to introduce impurities in the process of preparing porous HA materials, which will adversely affect the biocompatibility of materials

Therefore, the porous HA bone repair material prepared by the above method cannot fully meet the requirements of clinical use, and it is necessary to find a new preparation method to overcome the problems existing in the above preparation method

[0005] In addition to many deficiencies in the preparation technology of porous HA-based bone repair materials, it has also been found in clinical experiments that although it has a certain osteogenic induction activity, its ability to promote osteogenesis and inhibit osteoclastosis needs to be improved.

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