Visual polyhydroxy polymer embolism microsphere and preparation method thereof

A technology of embolic microspheres and polymers, applied in the field of medical materials, can solve the problems of increased difficulty, cumbersome operation steps, and vascular stimulation, and achieve the effects of simple operation, reduced surgical risk, and good scalability

Active Publication Date: 2017-08-18
SUZHOU HENGRUI CALLISYN BIOLOGICAL MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to achieve better embolization and imaging effects, it is necessary to mix embolization microspheres and ethyliodol to form a stable suspension system during the process of adding ethyliodol, but such a combination is often unstable, which means that the injection combination The substance needs to be prepared immediately before injection, and the ethyliodol and embolic microspheres may be in different positions in the tissue after injection, which greatly increases the difficulty of the doctor's operation. At the same time, the use of contrast medium will also directly stimulate blood vessels. , bringing additional risk
[0006] WO2014/152488 describes a polymer microsphere (LC/DC- ) to activate preformed hydrogel beads by nucleophilic attack, and then covalently attach iodine-containing compounds to polymer microspheres to prepare visualization microspheres. Th

Method used

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  • Visual polyhydroxy polymer embolism microsphere and preparation method thereof
  • Visual polyhydroxy polymer embolism microsphere and preparation method thereof
  • Visual polyhydroxy polymer embolism microsphere and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0036] Example 1

[0037]

[0038] Slowly add 50mL of dimethyl sulfoxide solution containing 419.0g of 3,5-diiodo-4-aminobenzaldehyde dimethyl acetal to a four-necked reaction flask containing an aqueous sodium hydroxide solution (40g, 300mL), and stir to make the solution Uniform; slowly add acryloyl chloride (99.5g) dropwise, and continue the reaction for 1 hour after the dropwise addition is complete. Then, saturated sodium chloride solution (100mL) was added to the above solution, ethyl acetate (2×200mL) was added for extraction, the organic phase was washed with water (2×100mL), and the crude product obtained after concentration of the organic phase was purified by column chromatography to obtain light Yellow oily product 3,5-diiodo-4-acrylamido benzaldehyde dimethyl acetal 1 (300g), HPLC purity 99.0%, 1 HNMR[DMSO-d 6 ]: 8.201 (s, 1H), 7.541 (s, 2H), 6.482-6.410 (m, 1H), 6.172-6.124 (m, 1H), 5.714-5.682 (m, 1H), 5.490 (s, 1H), 3.252(s, 6H).

Example Embodiment

[0039] Example 2

[0040]

[0041] In a 2L four-necked reaction flask, add 1000g of water and the molecular weight is 5×10 4 ~8×10 4 150g of polyvinyl alcohol, heated to 96°C for 4 hours, cooled the fully dissolved polyvinyl alcohol solution to room temperature, and added 15.7g of 3,5-diiodo-4-acrylamidobenzaldehyde dimethylacetal 10 mL of dimethyl sulfoxide solution and 100 mL of concentrated hydrochloric acid were reacted for 3 hours. After the reaction, 560 g of 2.5M sodium hydroxide solution was added. The collected crude product was concentrated to obtain 550 g of gel-like functionalized macromolecular intermediates with a viscosity of 3000 cps. The intermediate 2 is kept for use.

Example Embodiment

[0042] Example 3

[0043]

[0044] In a 2L reaction flask, add sodium 2-acrylamide-2-methylpropanesulfonate (20.0g), potassium persulfate (12.0g) and water, mix and stir until potassium persulfate is completely dissolved, and add it to the functionalization in Application Example 2. The macromolecular intermediate (400g) was stirred evenly to obtain the macromonomer solution, which was placed for later use. Add butyl acetate (2.5L) and the ethyl acetate solution (35g) of 10% butyl acetate cellulose to the 5L reaction kettle, blow in nitrogen, increase the temperature of the system to 63°C, add the above macromonomer solution and four Methyl ethylenediamine (20 mL), then the reaction was stirred at 58°C for 3 hours. After the reaction, the reaction mixture was washed sequentially with butyl acetate and acetone, filtered with suction, and dried under vacuum to obtain polyvinyl alcohol embolic microspheres 3 (80 g).

[0045] After being swelled and sieved, the embolic microspheres a...

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Abstract

The invention relates to a visual polyhydroxy polymer embolism microsphere and a preparation method thereof, belonging to the technical field of medical treatment materials. The visual embolism microsphere is prepared from functional macromolecules with biocompatibility and a cross-linking agent, namely an iodobenzene compound through cross-linking polymerization and is capable of reflecting or weakening X rays. The invention relates to a novel visual embolism microsphere in the technical field of medical materials and a preparation process of the novel visual embolism microsphere. According to the process, the defect that a contrast agent is added into a traditional surgical embolism process for developing is changed, the surgical risk is reduced, and convenience is provided for treating tumor diseases by virtue of a minimally invasive interventional therapy; the visual microsphere prepared by virtue of the preparation process is capable of reflecting or weakening the X rays and has good flexibility, elasticity and compression deformation property; and meanwhile, a traditional embolism microsphere needs to be dyed so as to guarantee that a doctor can conveniently observe in a surgical process, but the embolism microsphere prepared by virtue of the process is yellow and does not need to be dyed, so that the operation is simple and feasible.

Description

technical field [0001] The invention relates to a visualized polyhydroxy polymer embolic microsphere and a preparation method thereof, in particular to a preparation process of a visualized embolic microsphere with good deformation elasticity for minimally invasive interventional therapy for tumor diseases, belonging to the technical field of medical materials . Background technique [0002] In recent years, interventional embolization therapy has played an increasingly important role in clinical medicine, especially in the treatment of tumors rich in blood vessels such as liver cancer, kidney cancer, and uterine fibroids. The preferred alternative for treating tumors that cannot be surgically removed. At present, commonly used embolic materials for interventional embolization include microspheres, microcatheters, coils, silk threads, etc., and microspheres are highly targeted to specific tissues and organs, have good embolization effects, can be combined with chemotherapy ...

Claims

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Application Information

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IPC IPC(8): A61L24/06A61L24/04A61L24/08A61K9/16A61K47/32A61K47/10A61K47/36A61P35/00C08F16/06C08F8/30C08F8/36
CPCA61K9/1635A61K9/1641A61K9/1652A61L24/046A61L24/06A61L24/08A61L2300/416C08F8/36C08F16/06C08L29/04C08L71/02C08L3/02C08L5/08C08L1/284C08F8/30
Inventor 王鹤明柳小平汪青松徐伟春
Owner SUZHOU HENGRUI CALLISYN BIOLOGICAL MEDICINE TECH CO LTD
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