Biological membrane stent material with gradient degradation effect and preparation method thereof

A scaffold material and biofilm technology, which is applied in medical science, textiles, papermaking, prostheses, etc., can solve the problems affecting the transportation of nutrients and metabolites, and the difficulty of extracting or synthesizing biologically active factors, so as to achieve superior performance and good biological performance. Effect of compatibility, fast degradation rate

Active Publication Date: 2018-01-19
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the purification and cross-linking of natural polymers, as well as the difficulty in extracting or synthesizing bioactive factors, are important factors that limit its clinical application.
On the other hand, once one of the components in these bilayer structures degrades, it will form a dense barrier layer, which will greatly affect the delivery of nutrients and metabolites during tissue growth.

Method used

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  • Biological membrane stent material with gradient degradation effect and preparation method thereof
  • Biological membrane stent material with gradient degradation effect and preparation method thereof
  • Biological membrane stent material with gradient degradation effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Preparation of polycaprolactone (PCL) electrospinning solution

[0042] Weigh 0.6 g of PCL particles, dissolve them in 5 mL of trifluoroethanol, add 1.2 mg of calcium chloride, and stir for 1 hour to obtain polycaprolactone spinning solution.

[0043] (2) Preparation of polyurethane (PU) electrospinning solution

[0044] Polyurethane synthesis: Prepolymerize 20g PCL (molecular weight 2000) and 11.1g isophorone diisocyanate (IPDI) (molecular weight 222.28) under mechanical stirring, nitrogen atmosphere, and 75℃ for 4 h, then add about 0.1 mL of stannous octoate Continue to stir for 1 h, then add 5 g of lysine ethyl ester hydrochloride and continue to react for 3 h, then add about 0.1 mL of stannous octoate to react for 2 h, then add 10 mL of deionized water, and place the reaction system at 90°C for 2 h. , The degradable medical polyurethane material target product can be obtained by cooling at room temperature.

[0045] Polyurethane composite (PUO) electrospinning solution...

Embodiment 2

[0051] (1) Preparation of polycaprolactone electrospinning solution

[0052] Weigh 0.7 g of PCL particles, dissolve them in 5 mL of trifluoroethanol, add 2.1 mg of calcium nitrate, and stir for 1 h to obtain polycaprolactone spinning solution.

[0053] (2) Preparation of polyurethane electrospinning solution and polyurethane / n-HA mixed electrospinning solution

[0054] Polyurethane synthesis: 20g PCL (molecular weight 2000) and 11.1g isophorone diisocyanate (IPDI) (molecular weight 222.28) were pre-polymerized for 6 h under mechanical stirring, nitrogen atmosphere, and 75°C; then about 0.15 mL stannous octoate was added Continue to stir for 1 h, then add 5 g of lysine ethyl ester hydrochloride and continue to react for 3 h, then add about 0.15 mL of stannous octoate to react for 3 h, then add 10 mL of deionized water and place the reaction system at 90°C for maturation After 10 hours, the target product of degradable polyurethane can be obtained by cooling at room temperature.

[005...

Embodiment 3

[0065] (1) Preparation of polycaprolactone electrospinning solution

[0066] Weigh 0.8 g of PCL particles, dissolve them in 5 mL of dichloromethane, add 3.2 mg of calcium bromide, and stir for 1 h to obtain polycaprolactone spinning solution.

[0067] (2) Preparation of composite polyurethane electrospinning solution

[0068] Polyurethane synthesis: 40 g of polycaprolactone diol (molecular weight 4000) and 9.05 g of lysine diisocyanate (LDI) (molecular weight 226.23) were pre-polymerized under mechanical stirring, nitrogen atmosphere, and 40°C for 10 h, and then added approximately 0.15 mL of stannous chloride was stirred for 2 hours, then 8g of PEG (molecular weight 400) was added for 4 hours, and then about 0.15 mL of stannous chloride was added to react for 3 hours, and then 8 mL of deionized water was added and the reaction system was placed at 70 The target product of degradable polyurethane can be obtained by curing at ℃ for 10 h and cooling at room temperature.

[0069] Compos...

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Abstract

The invention relates to a biological membrane stent material with gradient degradation effect and a preparation method thereof. The biological membrane stent material is provided with an inner layer,a middle layer and an outer layer which are mutually combined, wherein the inner layer is an electrospinning fiber membrane and is prepared by mixing composite polyurethane of polyoxyethylene and nanometer hydroxyapatite into medical polyurethane material, the mass of the composite polyurethane is equal to 2.5 to 10wt% of the mass of the medical polyurethane material, and the mass of the nanometer hydroxyapatite is equal to 0 to 60wt% of the mass of the stent material; the middle layer is coated to the surface of the inner surface, and is a mixed electrospinning fiber membrane, and the mixedelectrospinning fiber membrane is formed by weaving the electrospinning fiber of polycaprolactone containing 0.2 to 0.5wt% of calcium salt component and the electrospinning fiber of composite polyurethane; the outer layer is coated to the surface of the middle layer, and is an electrospinning fiber membrane which is formed by the polycaprolactone containing 0.2 to 0.5wt% of calcium salt component.The biological membrane stent material has the advantages that the functions of the natural biological membrane can be simulated to promote the tissue regeneration, and the biological membrane stentmaterial can be widely applied to the fields and industries of biology and medicines.

Description

Technical field [0001] The invention relates to a stent material applied in the field of biomedicine, in particular to a biomembrane stent material that can be gradient degraded, and a preparation method of the biomembrane stent material. Background technique [0002] Tissue engineering scaffolds are currently an important part of tissue repair, which can provide a place for cell adhesion growth, nutrient and gas exchange, waste excretion, and growth and metabolism. The ideal tissue engineering scaffold should not only mimic the fibrous structure of natural extracellular matrix but also provide specific biological functions of the tissue. [0003] Electrospinning technology has gradually attracted the attention of researchers all over the world since its realization by Formhals and others in 1934. The diameter of the fiber obtained by electrospinning technology can vary from tens of nanometers to several microns. This fiber material can have a higher specific surface area, porosi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/12A61L27/02A61L27/50A61L27/58D04H1/728
Inventor 左奕孙富华李玉宝杨博渊邹琴李吉东
Owner SICHUAN UNIV
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