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Wormwood extract liniment for treating eczema

A technology of extract and wormwood, which is applied in the field of wormwood extract liniment for the treatment of eczema, can solve the problems of secondary allergies, multiple ingredients, complex ingredients, etc., to resist skin allergy symptoms, accelerate blood circulation, and inhibit bacterial growth Effect

Inactive Publication Date: 2018-02-09
马述腾
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Artemisia argyi oil is one of the active ingredients of wormwood, which has anti-inflammatory, anti-allergic, antibacterial, and antiviral effects, but excessive use can have adverse effects on the nervous system
[0004] The Chinese invention patent with application number 201510646496.4 "A traditional Chinese medicine composition for treating eczema" contains 26-35 parts of Artemisia argyi leaves, 24-33 parts of purslane, 19-24 parts of Schizonepeta, 20-27 parts of white fresh skin, cicada slough 18-26 parts, 17-25 parts of coptis, 19-26 parts of comfrey, 14-20 parts of astragalus, 13-20 parts of cassia bark, 16-21 parts of Albizia juliensis, 15-22 parts of Nocturna vine, 12-22 parts of Moringa leaves 18 parts, 13 to 19 parts of ginkgo leaves and 10 to 20 parts of licorice, the extract is obtained by alcohol extraction, microwave extraction, and reduced pressure concentration, and then used externally. This invention has complex ingredients and many ingredients, which can easily cause secondary allergies. And the external use of the extract is poor, and it is easy to cause problems such as polluting clothes
[0005] The Chinese invention patent with the application number 201410515433.0 "a pharmaceutical composition for treating infantile eczema and its preparation method" is made of comfrey, mugwort leaves, honeysuckle, chinensis, phellodendron, scutellaria baicalensis, houttuynia cordata, gypsum, and borneol. Alcohol extraction, oil immersion, and mixing steps, without purification steps, the content of active ingredients is small, and the content of impurities is high, which can easily cause skin allergic reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Purchase 100 kg of fresh wormwood whole herb, manually remove withered leaves, cut off the roots, wash the sediment, dry, chop, grind with a colloid mill, and collect 93.5 kg of homogenate. 50°C, natural pH value, add 0.94kg cellulase powder, stir evenly, enzymatically hydrolyze for 24h, heat and extract the enzymolyzed solution by steam distillation, reflux for 4h, the distillate is 0.9L crude extract of mugwort leaf oil. Use 200 mesh nylon mesh to filter the distillate after distillation to obtain 39.67kg of filtrate, obtain 9.41kg of raw material coarse powder after spray drying, dissolve the raw material coarse powder with 188.2kg of 60% ethanol solution, stir until fully dissolved, and obtain alcohol extract , use a membrane with a pore size of 45 μm for suction filtration, and retain the suction filtrate. Use a modified cellulose membrane with a molecular weight cut-off of 30kD to carry out ultrafiltration to remove impurities from the suction filtrate, add an equ...

Embodiment 2

[0029] Purchase 200kg of fresh wormwood whole herb, manually remove the withered leaves, cut off the roots, wash the sediment, dry, chop, grind with a colloid mill, and collect 189.6kg of homogenate. 50°C, natural pH value, add 3.5kg cellulase powder, stir well, enzymolyze for 24h, heat and extract the enzymolyzed solution by steam distillation, reflux for 5h, the distillate is 1.61L crude oil of mugwort leaves. Use 200 mesh nylon nets to filter the distillate after distillation, obtain 83.52kg of filtrate, obtain raw material coarse powder 19.15kg after spray drying, dissolve raw material coarse powder with 60% ethanol solution 385kg, stir until fully dissolved, obtain alcoholic extract, Use a membrane with a pore size of 45 μm for suction filtration, and retain the suction filtrate. Use a modified cellulose membrane with a molecular weight cut-off of 30kD to carry out ultrafiltration to remove impurities from the suction filtrate, add an equal volume of 60% ethanol solution,...

experiment example

[0031] 1. Diagnostic criteria

[0032]It is formulated with reference to the content of "Diagnostic Basis of Eczema" in "Diagnostic and Curative Criteria for Diseases and Syndromes of Traditional Chinese Medicine". The diagnostic criteria are:

[0033] 1. Acute eczema

[0034] 1) The skin lesions are pleomorphic, such as flushing, papules, blisters, erosions, exudations, crusts, and desquamation, and multiple forms exist at the same time.

[0035] 2) Acute onset, conscious burning, severe itching.

[0036] 3) Skin lesions are often distributed symmetrically, and are more common on the head, face, distal extremities, and scrotum. Can be distributed all over the body.

[0037] 4) It can develop into subacute or chronic eczema, which is sometimes mild and sometimes severe, and does not heal repeatedly.

[0038] 2. Subacute eczema: less exudation of skin lesions, mainly papules, papules, scabs, and scales. There is a mildly erosive surface, and the color is darker red. Mild...

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PUM

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Abstract

The invention belongs to the field of medicine, and particularly relates to a wormwood extract liniment for treating eczema, which is characterized in that it is prepared according to the following weight ratio: 27-33% of wormwood extract, 5-9% of dehydrated alcohol, stearic acid Glyceride 4-6%, Azone 4.5-5.5%, Glycerin 4-5%, Tween 80 3-5%, purified water to make up to 100%. The advantage of the present invention is that the production process of the wormwood extract is simple, and the flavonoid content in the wormwood extract is detected by ultraviolet spectrophotometry to be 25.11-34.06%; ) content is 2.107~2.514mg / g. After adding the transdermal agent azone, wormwood flavonoids can easily penetrate the skin surface, accelerate the metabolism of deep skin cells, inhibit platelet aggregation, and accelerate the blood circulation of eczema skin; mugwort oil can inhibit the growth of bacteria on the skin surface and resist skin allergy symptoms. The invention can rapidly alleviate the itching and other symptoms caused by skin eczema, and achieve the effect of treating both symptoms and root causes.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a mugwort extract liniment for treating eczema. Background technique [0002] Eczema is a clinically common inflammatory skin disease with complex etiology. According to statistics, the prevalence of eczema in developed countries is as high as 30% in children, and the incidence in adults is about 10%. Studies have shown that the prevalence of eczema in developing countries Prevalence tends to increase due to environmental degradation resulting from rapid economic growth. The internal causes of eczema include genetic factors, blood circulation disorders, endocrine changes or visceral lesions, etc.; the external causes of eczema include environmental factors, external infections, improper diet, and drug factors. Oral antihistamines combined with topical glucocorticoids are currently the most commonly used methods for the clinical treatment of eczema, but this treatment often only relieves ...

Claims

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Application Information

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IPC IPC(8): A61K36/282A61K9/00A61K47/22A61P17/04A61P31/02A61P31/04A61P37/08A61P17/00
CPCA61K36/282A61K9/0014A61K47/22A61K2236/19A61K2236/333A61K2236/37A61K2236/53A61K2300/00
Inventor 马述腾
Owner 马述腾
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