Preparation process of MAME (methyl 3-methoxyacrylate)

Abstract

The invention provides a preparation process of MAME (methyl 3-methoxyacrylate) and belongs to the technical field of synthesis of organic compounds. According to the preparation process, methyl acrylate and excess methanol taken as starting raw materials are subjected to an addition-etherification reaction in an oxygen atmosphere under the action of a synthetic catalyst, a product is subjected tofiltration and extraction, methyl 3,3-dimethoxypropionate is obtained and subjected to a catalytic cracking reaction, MAME and methanol are generated, the target product MAME is obtained through distillation, and methanol is recovered, wherein the synthetic catalyst is cobalt oxide, indium oxide or a mixture of cobalt oxide and indium oxide in any proportion. The preparation process is simple andefficient, the yield of the product MAME is higher and reaches 78%-82.4%, the catalyst can be recycled for a long time, corrosive and toxic substances are avoided, reaction equipment cannot be corroded, industrial production can be realized, and considerable economic benefits are created.

Description

technical field [0001] The invention discloses a process for preparing methyl 3-methoxyacrylate, which belongs to the technical field of organic compound synthesis. Background technique [0002] 3-Methoxymethyl acrylate (MAME) is a colorless and transparent liquid, a multifunctional compound with good reactivity, and is an important C-3 building block in organic synthesis, widely used in pesticides, medicines and polymers In the field of materials and other fields, it is used to synthesize a variety of organic compounds. It has a wide range of uses and a large demand. However, domestic industrialization is less and most rely on imports. [0003] The currently reported synthesis methods of MAME are as follows: 1) Wacker catalytic oxidation method: PdCl 2 and CuCl 2 As a catalyst, it catalyzes the efficient oxidation of acrylic acid and methanol into 3,3-dimethoxymethyl propionate and 3-methoxymethyl acrylate, and the conversion rate of acrylic acid reaches 95.2%. This metho...

AI Technical Summary

Problems solved by technology

[0002] 3-Methoxymethyl acrylate (MAME) is a colorless and transparent liquid, a multifunctional compound with good reactivity, and is an important C-3 building block in organic synthesis, widely used in pesticides, medicines and polymers In the field of materials and other fields, it is used to synthesize a variety of organic compounds. It has a wide range of uses and a large demand. However, domestic industrialization is less and most rely on imports.

[0003] The currently reported synthesis methods of MAME are as follows: 1) Wacker catalytic oxidation method: PdCl 2 and CuCl 2 As a catalyst, it catalyzes the efficient oxidation of acrylic acid and methanol into 3,3-dimethoxymethyl propionate and 3-methoxymethyl acrylate, and the conversion rate of acrylic acid reaches 95.2%. This method is simple and efficient, but the catalyst is expensive and difficult to recycle. 2) Methyl propiolate method: Methyl propiolate and ethanol are catalyzed by sodium cyanide or potassium carbonate to synthesize methyl 3,3-diethoxypropionate, cyanide The catalytic yield of sodium chloride is 75%, and the catalytic yield of potassium carbonate is 70%. The process is mature, but propiolic acid is expensive, the yield is not high, and sodium cyanide is highly toxic; 3) trimethyl orthoformate and Ketene method: ketene and trimethyl orthoformate are catalyzed by montmorillonite or boron trifluoride ether to prepare methyl 3,3-dimethoxypropionate, and then catalyzed by p-toluenesulfonic acid or similar substances Cracking to prepare methyl 3-methoxyacrylate, the reaction yield is not high, 52%, and the reaction process is violently exothermic; 4) Carbon tetrachloride method: Synthesize 1 with carbon tetrachloride and vinyl ether as raw materials , 1,1,3-Tetrachloro-3-ethoxypropane, reflux esterification of propane compound and methanol to prepare 3,3-dimethoxypropionate methyl ester, and then synthesize 3-methoxymethyl acrylate by cracking , the yield of the target product in this method is also low