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Application of hydroxyethyl starch to preparation of wound dressing

A technology of hydroxyethyl starch and hydroxyethyl, which is applied in the field of sanitary materials, can solve the problems of inability to effectively protect the wound surface, inability to absorb rapidly, and inability to form a colloidal protective layer, so as to facilitate wound healing, avoid adhesive intestinal obstruction, The effect of promoting increased gastrointestinal motility

Active Publication Date: 2018-07-13
SHANDONG WEIGAO HONGRUI MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the dissolution process of alginate, there will be a "fish eye" phenomenon, and the surface of the particles will swell with water to form a colloidal layer. At this time, the molecular chains have not formed random coils that can move freely. The formation delays and hinders the penetration of water molecules into the gel, and then the particles are cemented into a block, forming a large mass with an initial gel on the surface and a dry core inside. The wound dressing cannot quickly absorb the water and blood on the wound surface. , exudate and other liquids, and thus cannot form a colloidal protective layer, and cannot effectively protect the wound surface
[0010] In view of the above-mentioned problems of wound dressings, and the current wound dressings are mainly suitable for the protection of external wounds, wounds, etc., few wound dressings can be applied to internal wounds. The wound surface formed during the operation process absorbs liquids such as blood and exudate to form a colloidal protective layer to prevent infection, reduce the application of antibiotics, promote wound healing and prevent postoperative tissue adhesion, which has urgent clinical significance

Method used

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  • Application of hydroxyethyl starch to preparation of wound dressing
  • Application of hydroxyethyl starch to preparation of wound dressing
  • Application of hydroxyethyl starch to preparation of wound dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Weigh hydroxyethyl starch, sodium alginate, and calcium chloride according to Table 1. The molecular weight of hydroxyethyl starch is 135,000 Da, the molecular weight of sodium alginate is 6000 Da, and the G / M ratio is 1.50. Sodium alginate and hydroxyethyl starch The particle size of the fluidized granulator is 60 mesh; put the above raw materials into the fluidized granulator preheated to 70°C, start the fan of the fluidized granulator, and control the wind speed of the fluidized granulator to 25HZ, so that the material is in a fluidized state.

[0070] Table 1

[0071] Numbering

[0072] Add 100g of deionized water to the boiling granulator through the spray gun for granulation, control the motor speed when the spray gun sprays to 200rpm, the pressure is 0.2MPa, and control the wind speed of the boiling granulator to 25HZ, so that hydroxyethyl starch, sodium alginate, Calcium chloride and water are mixed and granulated, the inlet temperature of the granulat...

Embodiment 2

[0074] Weigh 500g of hydroxyethyl starch, 1000g of water-soluble chitosan, the pH of 1% aqueous solution of water-soluble chitosan is 6.5, the degree of deacetylation is 95%, the molecular weight of hydroxyethyl starch is 280,000 Da, add it to preheat to 70°C In the fluidized granulator, start the fan of the fluidized granulator, and control the wind speed of the fluidized granulator to 75HZ to make the material in a fluidized state.

[0075] Add 100g of deionized water to the boiling granulator through the spray gun for granulation, control the motor speed of the spray gun to 200rpm, the pressure 0.2MPa, and control the wind speed of the boiling granulator to 75HZ to make hydroxyethyl starch and water-soluble chitosan Sugar and water are mixed and granulated, the inlet temperature of the granulator is controlled at 90°C, the outlet temperature is 50°C, and the boiling granulation time is 2 minutes.

[0076]Packing and sealing the granulated wound dressing. Put the wound dres...

Embodiment 3

[0078] Weigh 1000g of absorbable oxidized cellulose, 5000g of hydroxyethyl starch, and 100g of β-glucan into the boiling granulator preheated to 70°C. The degree of polymerization of absorbable oxidized cellulose is 400, and the degree of polymerization of absorbable oxidized cellulose The carboxyl content in the mixture is 22%, and the molecular weight of hydroxyethyl starch is 500,000 Da; start the fan of the boiling granulator, and control the wind speed of the boiling granulator to 60HZ, so that the material is in a fluidized state.

[0079] Add 1000g of deionized water to the boiling granulator through the spray gun for granulation, control the motor speed of the spray gun to 200rpm, the pressure 0.2MPa, and control the wind speed of the boiling granulator to 60HZ, so that hydroxyethyl starch and oxidized fiber can be absorbed Vegetables, β-glucan and water were mixed and granulated, the inlet temperature of the granulator was controlled at 74°C, the outlet temperature was...

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Abstract

The invention discloses an application of hydroxyethyl starch to preparation of a wound dressing. The wound dressing is prepared from hydroxyethyl starch and a dressing carrier, wherein the hydroxyethyl starch is a product prepared by substituting corn starch containing a branch-chain with ethoxy, wherein the molecular weight is 10,000Da to 70,000Da. The wound dressing prepared with the hydroxyethyl starch has larger specific surface area, high porosity, and can be used for absorbing seepage on the wound; wound dressing can be combined through a coordination bond after absorbing water to builda network-staggered structure with extremely high crosslink degree, so that high viscosity and flexibility are achieved; a moist and micro-acid environment can be provided, local sterilizing performance is enhanced, anti-bacteria effect is durable, infection rate is lowered, the dosage of the antibiotic is lowered, the healing of the wound is facilitated, postoperative tissue adhesion is avoided;the hydroxyethyl starch has high biocompatibility, can be degraded effectively in a living body, is wide in application range, is low in production cost, and can be used for lowering medical cost.

Description

technical field [0001] The invention relates to the technical field of hygienic materials, in particular to the application of hydroxyethyl starch in making wound dressings. Background technique [0002] Clinically, wound repair refers to a series of pathophysiological processes in which wound tissue repairs through regeneration, repair, and reconstruction after tissue loss due to the action of injury factors. Wound care needs to be taken during the wound repair process, and problems such as wound infection, wound bleeding, and fluid accumulation that occur during the wound healing process will affect wound healing, and wounds that are difficult to heal for a long time may even cause life-threatening. [0003] Currently widely used wound dressings mainly include fibrous wound dressings, polymer film wound dressings, foaming polymer wound dressings, hydrocolloid wound dressings and hydrogel dressings. [0004] 1. Fibrous wound dressing can quickly absorb wound exudate, and t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/60
CPCA61L15/28A61L15/42A61L15/60C08L3/08
Inventor 杜武华刘奉杜武宁林栋青邱新林邓文平林艳华程龙
Owner SHANDONG WEIGAO HONGRUI MEDICAL TECH CO LTD