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Preparation method of HA/MoS2 biological composite coating, with photocatalytic activity, on surface of titanium alloy

A technology of photocatalytic activity and composite coating, which is applied in the interdisciplinary field of material science and biomaterials, can solve the problems of bacterial resistance, weak binding force, and functional effects, and achieve the effect of convenient acquisition and low price

Inactive Publication Date: 2018-08-03
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the general biological composite coating has the problem of weak binding force and cannot interact with the host for a long time, and the regulation and preparation of the biological structure requires sophisticated instruments for complex and delicate operations.
Although there are many ways to solve the antibacterial effect of implants, such as oral administration and injection of antibiotics, these traditional antibiotic antibacterial methods can easily lead to bacterial resistance and induce super-resistant bacteria that cannot be eliminated by any antibiotics.

Method used

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  • Preparation method of HA/MoS2 biological composite coating, with photocatalytic activity, on surface of titanium alloy
  • Preparation method of HA/MoS2 biological composite coating, with photocatalytic activity, on surface of titanium alloy
  • Preparation method of HA/MoS2 biological composite coating, with photocatalytic activity, on surface of titanium alloy

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Experimental program
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Effect test

preparation example Construction

[0022] A photocatalytically active HA / MoS on the surface of titanium alloy 2 The preparation method of biological composite coating, the steps include as follows:

[0023] S1. Combine HA and MoS 2 Powder mixing and formulation of HA / MoS at a concentration of 1-200mg / mL 2 solution, ultrasonication, and then drop the obtained mixed solution onto the surface of the substrate, and after drying, the surface of the substrate with HA / MoS 2 Pre-coated samples;

[0024] Preferably, in step S1, HA and MoS 2 The mass ratio is 1-100:1-100;

[0025] Preferably, in step S1, ultrasonication is performed in an ultrasonic machine above 500W for 0.5-2h;

[0026] Preferably, in step S1, the volume of the mixed solution dripped onto the surface of the substrate is 10-100uL;

[0027] Preferably, in step S1, the specific method of drying is: place the substrate with the mixed solution dripped on the surface in an oven, and dry it at 25-65°C for 0.3-3h;

[0028] S2. Laser cladding treatment i...

Embodiment 1

[0036] A photocatalytically active HA / MoS on the surface of titanium alloy 2 The preparation method of biological composite coating, the steps include as follows:

[0037] S1. Mix 5mg of HA powder and 5mg of MoS 2 Mix the powders and prepare 1ml of HA / MoS with a concentration of 10mg / mL with deionized water 2 Suspension (50% MoS 2 ), put the obtained suspension into a 600W power ultrasonic instrument for 1h, and then use a pipette to draw 50uL of HA / MoS 2 The suspension was added dropwise to the surface of Ti6Al4V, put into an oven, and dried at 60 °C for 1 h, so that the surface of Ti6Al4V was coated with HA / MoS 2 pre-coating;

[0038] S2. The sample obtained in step S1 is placed on a two-dimensional laser platform, and the laser current is set to 100A, the frequency is 20Hz, and the pulse width is 2ms, and laser cladding is performed;

[0039] S3, due to the laser treatment in S2, there is a part of MoS on the surface of Ti6Al4V 2 oxidized to MoO 3-X , therefore, put ...

Embodiment 2

[0042] This embodiment provides a preparation method before and after vulcanization of the prefabricated coating in proportion, and the steps include as follows:

[0043] S1, 2.5mg of HA powder and 7.5mg of MoS 2 Mix the powders and prepare 1ml of HA / MoS with a concentration of 10mg / mL with deionized water 2 Suspension (75% MoS 2 ), put the obtained suspension into a 600W power ultrasonic instrument for 1h, and then use a pipette to draw 50uL of HA / MoS 2 The suspension was added dropwise to the surface of Ti6Al4V, put into an oven, and dried at 60 °C for 1 h, so that the surface of Ti6Al4V was coated with HA / MoS 2 pre-coating;

[0044] S2. Place the sample obtained in step S1 on a two-dimensional laser platform, and set the laser current to 100A, frequency to 20Hz, and pulse width to 2ms to perform laser cladding treatment, and then separate a part of the sample and mark it as 75% L-MoS 2 ;

[0045] S3, due to the laser treatment in S2, there is a part of MoS on the surf...

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Abstract

The invention discloses a method of preparing a hydroxyapatite / molybdenum disulfide biological composite coating, with the photocatalytic activity, on the surface of titanium alloy. The method endowsthe coating with excellent biocompatibility, bone formation performance and photocatalytic sterilization. The method comprises the following steps of firstly, preparing an HA / MoS2 suspension liquid, performing ultrasonic treatment, and dropwise adding the suspension liquid on the surface, subjected to polishing treatment, of Ti6Al4V with a pipette to form a preset coating; then performing laser treatment to enable the preset coating to be firmly combined with a base; and finally, performing sulphur treatment on a sample after laser cladding through a CVD furnace to prepare the HA / MoS2 biological composite coating. The method has the advantages that through a preparation method by combining a laser cladding technology with a CVD phase, except that combination of the coating and the Ti6Al4Vbase is firm, HA in the coating can effectively exert the advantages of the biocompatibility, bone formation and osseointegration, and meanwhile, MoS2 in the coating can produce a photocatalytic product through illumination with 660nm laser light, can effectively oxidize cell walls and cytomembranes of bacteria and damage DNA of the bacteria so as to cause bacteria apoptosis.

Description

technical field [0001] The invention relates to the interdisciplinary technical field of material science and biomaterials, specifically a HA / MoS with photocatalytic activity on the surface of titanium alloy 2 Preparation method of biocomposite coating. Background technique [0002] As an important titanium alloy, Ti6Al4 is widely used in bone implant surgery and orthopedic surgery because of its excellent toughness and strength as an implant material. However, due to its own inertia, it cannot accelerate the repair of bone tissue and shorten the recovery time, and postoperative infection caused by external factors during the implantation process often leads to surgical failure, forcing patients to undergo a second operation, which not only increases the number of patients The pain of reoperation also increases the heavy economic burden for patients. [0003] Therefore, titanium alloy implants urgently need to solve both biological activity and antibacterial problems. Mor...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/30A61L27/32A61L27/50A61L27/54C23C24/10
CPCA61L27/06A61L27/306A61L27/32A61L27/50A61L27/54A61L2300/102A61L2300/404A61L2300/606A61L2420/02A61L2420/06A61L2430/02C23C24/10
Inventor 刘想梅张演哲吴水林李朝阳朱胜利崔振铎杨贤金
Owner HUBEI UNIV
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