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Self-polymeric medical repair material for enhancing rapid fracture repair and application method

A technology for repairing materials and application methods, applied in the field of medical materials, can solve problems such as long repair time, no substantial breakthrough, easy to break again, etc., to improve strength, enhance biocompatibility, and improve normal shape and strength Effect

Inactive Publication Date: 2018-09-21
CHENDU NEW KELI CHEM SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] It can be seen that the rapid repair of fractures in the prior art has always been the key to bone repair, but no substantial breakthrough has been made at present, and the existing fractures and bone damage repair still have long-term fixation, long repair time, and post-repair Disadvantages such as the risk of easy to break again

Method used

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  • Self-polymeric medical repair material for enhancing rapid fracture repair and application method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Medical repair materials are composed of A agent and B agent:

[0030] Agent A consists of 11kg of low molecular weight polybutadiene with a number average molecular weight of 40,000, 32kg of silicone acrylate dispersion, 14kg of polyurethane prepolymer, 17kg of chondroitin, 13kg of silk protein, 9kg of alginic acid, and 4kg of lactide; The B agent is composed of 2kg dibenzoyl peroxide, 1kg ethanedithiol, 2kg diethylaminoethanol, 36kg nano-bone powder, and 59kg nano-cellulose fiber dispersion; the solid content of the silicone acrylate dispersion is 39 %, the component of silicone acrylate is 6kg silicone and 6.48kg acrylate; the solid content of nanocellulose fiber dispersion is 53%, and the average diameter of nanocellulose fiber is 500nm.

[0031] The application process of medical repair materials is:

[0032] Mix Agent A and Agent B evenly at room temperature at a mass ratio of 2:1, and inject it into fractures and bone defects for 8 minutes; fix it with a plaster...

Embodiment 2

[0037] Medical repair materials are composed of A agent and B agent:

[0038]Agent A consists of 8kg of low molecular weight polybutadiene with a number average molecular weight of 30,000, 43kg of silicone acrylate dispersion, 12kg of polyurethane prepolymer, 15kg of chondroitin, 12kg of silk protein, 7kg of alginic acid, and 3kg of lactide; The B agent is composed of 1kg dibenzoyl peroxide, 1kg 1-propanethiol, 1kg glycerin, 30kg nano-bone powder, and 67kg nano-cellulose fiber dispersion; the solid content of the silicone acrylate dispersion is 32%, organic The components of silicon acrylate are 6.76kg of silicone and 7kg of acrylate; the solid content of the nanocellulose fiber dispersion is 48%, and the average diameter of the nanocellulose fibers is 300nm.

[0039] The application process of medical repair materials is:

[0040] Mix Agent A and Agent B uniformly at room temperature at a mass ratio of 3:1, inject into fractures and bone defects, and the injection time is 7 ...

Embodiment 3

[0043] Medical repair materials are composed of A agent and B agent:

[0044] Agent A consists of 12kg of low molecular weight polybutadiene with a number average molecular weight of 50,000, 24kg of silicone acrylate dispersion, 15kg of polyurethane prepolymer, 20kg of chondroitin, 14kg of silk protein, 10kg of alginic acid, and 5kg of lactide; The B agent is composed of 2kg dibenzoyl peroxide, 2kg 1,3-propanedithiol, 3kg trimethylolpropane, 40kg nano-bone powder, 53kg nano-cellulose fiber dispersion; the silicone acrylate dispersion The solid content is 45%, the silicone acrylate component is 5.1kg silicone and 5.7kg acrylate; the solid content of the nanocellulose fiber dispersion is 65%, and the average diameter of the nanocellulose fiber is 800nm.

[0045] The application process of medical repair materials is:

[0046] Mix Agent A and Agent B uniformly at room temperature at a mass ratio of 3:1, inject into fractures and bone defects, and the injection time is 9 minutes;...

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Abstract

The invention belongs to the technical field of medical materials, and provides a self-polymeric medical repair material for enhancing rapid fracture repair and an application method. The material comprises an A agent which comprises low molecular weight polybutadiene, a silicone acrylate dispersion liquid, a polyurethane prepolymer, chondroitin, a silk protein, alginic acid and lactide, and a B agent which comprises dibenzoyl peroxide, mercaptan, a chain extender, nano bone powder and a nanocellulose fiber dispersion liquid. Compared with the traditional materials, the bone repair material, prepared by the invention, can be self-polymerized by heat treatment, can effectively achieve the purpose of rapid bone repair, is good in biocompatibility and high in polymerization strength, and is of great significance for shortening of a bone repair period and improvements on the normal shape and strength of the bone after recovery.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and provides a medical repair material and an application method for self-aggregation enhanced rapid repair of fractures. Background technique [0002] All over the world, the repair and reconstruction of fractures and bone defects caused by trauma, tumors, infections, congenital defects, osteoporosis and other reasons has always been one of the orthopedic problems. In cases where bone self-repair cannot heal, bone grafting is required. Although autologous bone grafting is currently the most effective clinical treatment, its application is limited due to the shortcomings of limited sources and secondary trauma. Therefore, the clinical application prospects of bone substitute materials and bone tissue engineering are extremely broad, and research in this field is a hot issue in the international orthopedic field. [0003] The characteristics that an ideal bone repair material should pos...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/16A61L27/18A61L27/36A61L27/20A61L27/22
CPCA61L27/50A61L27/16A61L27/18A61L27/20A61L27/227A61L27/3608A61L2400/06A61L2430/02C08L9/00C08L75/04C08L5/04C08L89/00C08L1/02C08L5/08
Inventor 陈庆曾军堂
Owner CHENDU NEW KELI CHEM SCI CO LTD
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