Low-heat-release and high-biological-activity compound bone cement and preparation method thereof

A bioactive, bone cement technology, applied in the direction of medical preparations with non-active ingredients, drug combinations, bone diseases, etc., can solve the problems of refractory degradation, short service life of PMMA bone cement, easy to become a source of infection, etc., to achieve good biological The effects of compatibility, excellent mechanical properties, and broad application prospects

Inactive Publication Date: 2019-04-16
SHANDONG RIENTECH MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, PMMA bone cement is currently the most commonly used common bone cement in clinical practice. It has high mechanical strength and injectability. As high as 100 ℃, it is easy to cause peripheral nerve function damage, and its biocompatibility is poor, and residual polymerized monomers will cause bone damage. At the same time, excessive mechanical strength will easily lead to interventional treatment failure. In addition, the use of PMMA bone cement Short life expectancy and secondary surgery is required, which greatly limits its clinical application and promotion
[0003] Hydroxyapatite is similar to the inorganic components of human bones. It is a widely used bioactive material. However, under normal circumstances, its crystallinity is high, and it is relatively stable and difficult to degrade after implantation. It is easy to remain in the body for a long time. Become a source of infection, causing an inflammatory reaction at the implant site, thus affecting the complete recovery of the bone defect

Method used

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  • Low-heat-release and high-biological-activity compound bone cement and preparation method thereof
  • Low-heat-release and high-biological-activity compound bone cement and preparation method thereof
  • Low-heat-release and high-biological-activity compound bone cement and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1: Polymethyl methacrylate composite bone cement mixed with graphene and strontium-silver-hydroxyapatite

[0050] (1) 0.5 g of graphene and 1.18 mL of normal saline were used to prepare a graphene suspension by combining an ultrasonic cell pulverizer with an ultrasonic cleaner;

[0051] (2) Mix the above graphene suspension with 4.5 g strontium-silver-hydroxyapatite evenly, and mix it with 95 g polymethyl methacrylate, 38 mL methyl methacrylate, 0.02 mL hydroquinone , 0.8 mL N,N-dimethyl-p-toluidine, mix well, and record the temperature at 28 days of reaction with a thermometer, then inject 40×40×160 mm3 Put it in a triple mold with a temperature of 37 ± 1 ℃ and a humidity of 90% in a constant temperature and humidity curing box for curing until the specified age, and carry out compressive and flexural strength tests.

[0052] The temperature during the polymerization process is 65 °C; the compressive strength is 50 MPa, and the flexural strength is 10 MPa.

Embodiment 2

[0053] Example 2: Polymethyl methacrylate composite bone cement mixed with graphene and strontium-silver-hydroxyapatite

[0054] (1) 1 g of graphene and 1.18 mL of normal saline were used to prepare a graphene suspension by combining an ultrasonic cell pulverizer with an ultrasonic cleaner;

[0055] (2) Mix the above graphene suspension with 4 g strontium-silver-hydroxyapatite evenly, and mix it with 95 g polymethyl methacrylate, 38 mL methyl methacrylate, 0.02 mL hydroquinone , 0.8 mL N,N-dimethyl-p-toluidine, mix well, and record the temperature at 28 days of reaction with a thermometer, then inject 40×40×160 mm 3 Put it in a triple mold with a temperature of 37 ± 1 ℃ and a humidity of 90% in a constant temperature and humidity curing box for curing until the specified age, and carry out compressive and flexural strength tests.

[0056] The temperature during polymerization was 55 °C; the compressive strength was 65 MPa and the flexural strength was 13 MPa.

Embodiment 3

[0057] Example 3: Polymethyl methacrylate composite bone cement mixed with graphene and strontium-silver-hydroxyapatite

[0058] (1) 2 g of graphene and 1.18 mL of normal saline were used to prepare a graphene suspension by combining an ultrasonic cell pulverizer with an ultrasonic cleaner;

[0059] (2) Mix the above graphene suspension with 3 g strontium-silver-hydroxyapatite evenly, and mix it with 95 g polymethyl methacrylate, 38 mL methyl methacrylate, 0.02 mL hydroquinone , 0.8 mL N,N-dimethyl-p-toluidine, mix well, and record the temperature at 28 days of reaction with a thermometer, then inject 40×40×160 mm 3 Put it in a triple mold with a temperature of 37 ± 1 ℃ and a humidity of 90% in a constant temperature and humidity curing box for curing until the specified age, and carry out compressive and flexural strength tests.

[0060] The temperature during polymerization was 45 °C; the compressive strength was 80 MPa and the flexural strength was 23 MPa.

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Abstract

The invention discloses low-heat-release and high-biological-activity compound bone cement and a preparation method thereof. The compound bone cement is prepared by mutually mixing 40-80% of solid phase powder and 10-50% of a liquid phase, wherein the solid phase powder comprises graphene, polymethyl methacrylate and hydroxyapatite; the liquid phase comprises methyl methacrylate, hydroquinone anddimethyl-p-toluidine. The compound bone cement is high in syringeability and biological activity; by adding the graphene with the super-high specific surface area, it is ensured that in the using process of the PMMA bone cement, the reaction heat of the PMMA bone cement is gradually released without injuring surrounding bone tissue, and it is ensured that the bone cement has a high plasticity andis capable of being shaped at random. In the solidification process, the polymerization heat release temperature is greatly lowered, the overall performance is excellent, the bone cement can meet requirements of filling and repair of bone defects, and the bone cement can be used as a drug carrier to treat orthopedic related diseases.

Description

technical field [0001] The invention specifically relates to a composite bone cement with low heat release and high biological activity, a preparation method and application thereof, and belongs to the technical field of medical materials. Background technique [0002] Currently commonly used bone cements include polymethyl methacrylate (PMMA), calcium phosphate (CPC), magnesium phosphate cement (MPC) and calcium sulfate (CSC) bone cement. Among them, PMMA bone cement is currently the most commonly used common bone cement in clinical practice. It has high mechanical strength and injectability. As high as 100 ℃, it is easy to cause peripheral nerve function damage, and its biocompatibility is poor, and residual polymerized monomers will cause bone damage. At the same time, excessive mechanical strength will easily lead to interventional treatment failure. In addition, the use of PMMA bone cement The short life expectancy requires secondary surgery, which greatly limits its c...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/44A61L27/50A61L27/54A61K47/02A61K47/04A61K47/32A61P19/08
CPCA61L27/46A61K47/02A61K47/32A61L27/443A61L27/446A61L27/50A61L27/54A61L2300/104A61L2300/112A61L2300/412A61L2430/02A61P19/08C08L33/12
Inventor 张海军周超徐凯丽崔晓珊宋彩霞冯相蓺张军伟
Owner SHANDONG RIENTECH MEDICAL TECH
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