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Application of yamcin Ⅲ in the preparation of medicines and cosmetics

A kind of yam element, product technology, applied in the direction of cosmetics, cosmetic preparations, ether preparation, etc., can solve the problems of pigment instability, skin damage, etc.

Active Publication Date: 2022-01-11
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the whitening and anti-aging skin care products used today are added with arbutin, ascorbic acid, kojic acid, cell growth factors, etc. Long-term use of these chemical components will cause pigment instability and cause certain damage to the skin

Method used

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  • Application of yamcin Ⅲ in the preparation of medicines and cosmetics
  • Application of yamcin Ⅲ in the preparation of medicines and cosmetics
  • Application of yamcin Ⅲ in the preparation of medicines and cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] batatasinⅢorthogonal process

[0033] 1.1 Material test material: Bletilla striata medicinal material was produced in Hubei in July 2017, and was identified as a dried pseudobulb of Bletilla striata by the Kunming Institute of Botany, Chinese Academy of Sciences. The dried pseudobulbs of Baiji are crushed with a pulverizer and passed through a 40-mesh aperture sieve, sealed and stored for later use.

[0034] 1.2 Reagents: BatatasinⅢ standard products are self-made in the laboratory; absolute ethanol, methanol, and acetonitrile are all chromatographically pure, and are products of Sinopharm Chemical Reagent Company.

[0035] 1.3 Instruments Agilent 1260HPLC high performance liquid phase; KERN electronic analytical balance (Beijing Sartorius Instrument System Co., Ltd.); Heidolp rotary evaporator (German Hei-VAP company); chromatographic column

[0036] ZORBAX SB-C 18 (4.6×250mm, Agilent, USA).

[0037] 1.4 Test method

[0038] 1.4.1 Chromatographic conditions: using ...

Embodiment 2

[0058] After crushing 8.0 kg of white and dried tubers, soak them in ethanol (80%) at room temperature for 3 times, dissolve the concentrated extract under reduced pressure in water, and extract with ethyl acetate and n-butanol successively to obtain 220 g of ethyl acetate and n-butanol respectively 500g (obtain the active part extract, that is, white and extract). Ethyl acetate part (270g) silica gel mixed sample (200-300 mesh) was eluted by silica gel column chromatography with chloroform-methanol gradient (50:1-4:1), and was detected by TLC and merged into 9 components (Fr.A – I). Fr.A (60.9 g) was eluted with medium pressure ODS methanol-water (30% - 100%) to give 9 fractions. Fr.A2 (5.3g) was eluted with Sephadex LH-20 (chloroform-methanol 1:1), and then subjected to silica gel column chromatography, petroleum ether-acetone (3:1-1:1), to obtain the compound and the compound identified in the literature It is batatasin III (4.8 g).

Embodiment 3

[0060] Evaluation of whitening and anti-aging activities of whitening and anti-aging activities of whitening and extracts and its monomer compound batatasin III

[0061] 3.1 Experimental cells and reagents

[0062] Human dermal fibroblasts-adult (HDFa) were purchased from Cascade Biologics. DMEM (high glucose) medium, PBS, Hank's balanced salt solution (HBSS), penicillin and fetal bovine serum (FBS) were purchased from Hyclone Company; 0.25% trypsin (containing EDTA) was purchased from Gibico Company ; DPPH, water-soluble vitamin E (Trolox), mushroom tyrosinase, levodopa (L-Dopa) and kojic acid (KojicAcid) were purchased from Sigma Company; transforming growth factor β (transforming growth factor beta, TGF-β) Purchased from Peprotech Company; Collagen ELISA kit was purchased from TaKaRa Company; MTS reagent was purchased from Promega Company.

[0063] 3.2 Experimental method

[0064] 3.2.1 DPPH free radical scavenging experiment

[0065] Mix and react the drug to be tested...

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Abstract

The invention discloses an application of extracting batatasin III (batatasin III) and its analogs from bletilla tubers and natural products, and bletilla extracts in the preparation of cosmetics for promoting collagen secretion to achieve anti-aging effects. The compound batatasin III disclosed in the present invention is extracted from plants of the genus Bletach and related plants of Orchidaceae, and the content of plants of the genus Bletilla is the highest. The compound has good anti-oxidation and collagen secretion promotion functions, and can be used for anti-aging Skin care products.

Description

technical field [0001] The invention relates to the fields of biomedicine and cosmetics. In particular, it relates to a monomer component batatasin III with whitening effect and an extraction method from batatasin III. The monomer compound batatasin III (batatasin III) and the monomer compound in the invention have whitening and anti-aging effects, and can be added to cosmetics as functional additives. Background technique [0002] Since ancient times, "everyone has the love of beauty". Whether a person is beautiful or not is first shown on the face. Whitening and anti-aging are the focus of attention in the field of skin care products. Most of the whitening and anti-aging skin care products used today contain arbutin, ascorbic acid, kojic acid, cell growth factors, etc. Long-term use of these chemical components will cause pigment instability and cause certain damage to the skin. With the continuous research and development of natural products, people have shifted their a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/09A61K8/34A61K8/9794A61Q19/02A61Q19/08A61K36/898A61P39/06C07C41/34C07C41/36C07C43/205
Inventor 胡江苗王雅琴杨柳李金玉任福才周俊
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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