Fluorine and silicon-containing polyurethane material with high biostability and preparation method thereof

A polyurethane material and bio-stability technology, which is applied in the field of fluorine-containing silicon-containing polyurethane materials and their preparation, can solve the problems that the bio-stability and mechanical properties cannot be improved at the same time, the mechanical properties of polyurethane are reduced, and the preparation cost is expensive, so as to improve the body and surface properties, the effect of improving biological stability

Active Publication Date: 2019-07-30
眉山尤博瑞特种新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the introduction of fluorocarbons into the soft segment or hard segment of polyurethane will lead to a reduction in the mechanical properties of polyurethane, and the preparation of diols containing fluorocarbon side chains or fluorine-containing polyglycols is expensive
[0005] At present, the biological stability and mechanical properties of polyurethane materials are difficult to be guaranteed at the same time. How to develop new preparation methods to solve the problem that the biological stability and mechanical properties cannot be simultaneously improved during the preparation process has become an urgent technical problem to be solved.

Method used

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  • Fluorine and silicon-containing polyurethane material with high biostability and preparation method thereof
  • Fluorine and silicon-containing polyurethane material with high biostability and preparation method thereof
  • Fluorine and silicon-containing polyurethane material with high biostability and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] The first step, the preparation of fluorosilicone polyether polyurethane prepolymer, add 90g of polytetrahydrofuran ether diol and 22g of hydroxyalkyl-terminated polydimethylsiloxane into a three-necked bottle with mechanical stirring at 100-105°C Vacuum dehydration for 2 hours until the water content in the raw material is less than 0.01%; then blow in N 2And cool down to 60-65°C, add 3.06g FDO (fluorine-containing dihydric alcohol), stir evenly and continue to cool down to 40-42°C, add 51g of molten completely transparent liquid MDI (methylene diphenyl diisocyanate) and 0.1% organic bismuth catalyst, stir rapidly until the temperature rises to 68-70°C, and maintain the temperature for 50 minutes until the NCO (isocyanate group) content reaches the designed theoretical value, that is, the fluorosilicon polyether polyurethane prepolymer is obtained.

[0037] The second step is the post-chain extension reaction. Cool the prepolymer prepared in the first step to 58-60°C, ...

Embodiment 2

[0040] The first step, the preparation of fluorosilicon polyether polyurethane prepolymer, add 0.095mol polyhexamethylene ether glycol and 0.005mol hydroxyethoxyl hydrocarbon group-terminated polydimethylsiloxane into three Vacuum dehydrate the bottle at 100-105°C for 2 hours until the water content in the raw material is less than 0.01%; then blow N 2 And lower the temperature to 60-65°C, add 0.01molHEPFOA (N-(1,1-Dihydroxymethylethyl) perfluorooctylamide, see patent: fluorine-containing diol CN1435410A), stir well and continue to cool down to 40- 42°C, add 0.25mol HDI (hexamethylene 1,6-diisocyanate) and 0.05% stannous octoate, stir rapidly until the temperature rises to 75-80°C, and maintain the reaction at this temperature for 50min until the NCO content reaches Design the theoretical value to obtain the fluorosilicone polyether polyurethane prepolymer.

[0041] The second step is the post-chain extension reaction. Cool the prepolymer prepared in the first step to 58-60 °...

Embodiment 3

[0044] The first step, the preparation of fluorosilicone polycarbonate polyurethane prepolymer, add 0.005mol poly 1,6-hexyl carbonate diol and 0.095mol hydroxyalkyl terminated polydimethylsiloxane into three Vacuum dehydrate the bottle at 100-105°C for 2 hours until the water content in the raw material is less than 0.01%; then blow N 2 And cool down to 60-65°C, add 0.001mol FDO, stir evenly and continue to cool down to 40-42°C, add 0.204mol molten and completely transparent liquid MDI and 0.1% organic bismuth, stir rapidly until the temperature rises to 50-55°C , and maintain the temperature at this temperature for 50 minutes until the NCO content reaches the design theoretical value, that is, the fluorosilicon polycarbonate polyurethane prepolymer is obtained.

[0045] The second step is the post-chain extension reaction. Add 0.099mol BDO to the prepolymer prepared in the first step, stir evenly at a high speed and raise the temperature to about 100°C. When the viscosity of ...

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Abstract

The invention provides a fluorine and silicon-containing polyurethane material with high biostability and belongs to the field of biomedical materials. Polyurethane of the polyurethane material is copolymerized by adopting polyether or polycarbonate diol as a first flexible chain segment, polydimethylsiloxane diol as a second flexible chain segment and diisocyanate and a chain extender as a rigidchain segment, wherein the chain extender is a diol blend of small-molecule diol or diamine and a side chain fluorine-containing alkyl group. By utilizing the low surface energy characteristic of thetwo elements, namely fluorine and silicon, in the process of melt processing or solution processing of the polyurethane, the two elements, namely fluorine and silicon can synergistically migrate to the surface to form a protective layer, water and oxidizing media can be prevented from penetrating into the material to improve the hydrolysis resistance and oxidation resistance of the material, the polyurethane material has excellent surface performance and ontological performance while the biostability is improved, and the material can be applied to the field of long-term implantation of medicalmaterials, such as artificial blood vessels, artificial heart valves, heart pulser wires and various interventional catheters.

Description

technical field [0001] The invention belongs to the technical field of polyurethane material preparation, and in particular relates to a fluorine-containing silicon-containing polyurethane material with high biological stability and a preparation method thereof. The material can be used as a medical material, especially a long-term implant material. Background technique [0002] Due to the excellent physical and mechanical properties and good biocompatibility of polyurethane, it has gained extensive attention in the field of biomedicine. However, the deficiencies in the stability of polyurethane limit its application as a long-term implant material to a certain extent, and it still faces great challenges in the application of cardiac pacemaker insulated wires and heart valves. In vivo biological stability is relatively poor. At present, polyether polyurethane (PEU) and polycarbonate polyurethane (PCU) are commonly used as long-term implant materials, but these two materials...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/66C08G18/61C08G18/48C08G18/38C08G18/32C08G18/44
CPCC08G18/3812C08G18/3825C08G18/44C08G18/4825C08G18/4854C08G18/61C08G18/664C08G18/6674
Inventor 谭鸿李震李洁华叶恒
Owner 眉山尤博瑞特种新材料有限公司
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