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A pH-responsive in-situ controlled-release titanium-based implant and its preparation method and application

An implant, titanium-based technology, applied in the medical field, can solve problems such as low efficiency, high infection rate, bacterial infection, etc., and achieve the effect of reducing adverse effects, excellent antibacterial properties, and promoting bone repair

Active Publication Date: 2021-09-21
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the open environment of bone defect pathology and the impaired immune system make titanium-based implants generally have the risk of bacterial infection during the application process, and the infection rate in clinical statistics is as high as 4%.
The current method of preoperative and postoperative systemic administration of antibiotics used clinically is inefficient and difficult to effectively prevent and solve the problem. Therefore, the design and construction of an in situ antibacterial surface allows antibacterial molecules to be implanted into the patient's body with the implant, and realizes in situ Precise antibacterial in situ at the implant site has become an effective method to prevent and solve bacterial infections

Method used

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  • A pH-responsive in-situ controlled-release titanium-based implant and its preparation method and application
  • A pH-responsive in-situ controlled-release titanium-based implant and its preparation method and application
  • A pH-responsive in-situ controlled-release titanium-based implant and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] (1) Titanium-based implant was subjected to ultrasound washing by acetone, ethanol and deionized water, and then treated with hydrofluoric acid having a volume of 4% by concentration of 4%.

[0057] (2) Ammonium sulfate and ammonium fluoride were dissolved with deionized water to give 0.5 m ammonium sulfate and 1 wt.% Of the ammonium fluid mixture, and the solution pH to 4 was adjusted by sulfuric acid.

[0058] (3) The titanium-based implant after the hydrofluoric acid treatment in step (1) is an negative electrode, and the platinum sheet is a positive electrode, and the anodization is performed using an electrochemical workstation in constant voltage mode, wherein the voltage is 10V, anodic oxidation time. 0.5h, the electrode spacing is 2 cm.

[0059] (4) The titanium-based implantation body having a titanium dioxide nanotube structure after the anodized surface was rinsed with deionized water, and dried at 60 ° C. figure 1 A schematic diagram of a titanium-based implant ...

Embodiment 2

[0067] (1) Titanium-based implant was subjected to ultrasound washing by acetone, ethanol and deionized water, and then treated with hydrofluoric acid having a volume of 4% by concentration of 4%.

[0068] (2) Ammonium ammonium sulfate and ammonium fluoride were dissolved with deionized water to give 0.5 m ammonium sulfate and 3 wt.% Of the ammonium fluid mixture, and the solution pH to 5 was adjusted by sulfuric acid.

[0069] (3) The titanium-based implant after the hydrofluoric acid treatment in step (1) is an negative electrode, and the platinum sheet is a positive electrode, and the anodization of the electrochemical workstation in constant pressure mode, wherein the voltage is 30V, anodation time 0.5h, the electrode spacing is 5 cm.

[0070] (4) The titanium-based implantation body having a titanium dioxide nanotube structure after the anodized surface was rinsed with deionized water, and dried at 60 ° C.

[0071] (5) Dissolve dicamine in Tris / HCl buffer solution (pH = 6.8...

Embodiment 3

[0078] (1) Titanium-based implant was subjected to ultrasound washing by acetone, ethanol and deionized water, and then treated with hydrofluoric acid having a volume of 4% by concentration of 4%.

[0079] (2) Ammonium sulfate and ammonium fluoride were dissolved with deionized water to give 0.5 M ammonium sulfate and 5 wt.% Of ammonium fluid mixture, and the solutions pH to 6 were modulated with sulfuric acid.

[0080] (3) The titanium-based implant after the treatment of hydrofluoric acid in step (1) is an negative electrode, and the platinum sheet is a positive electrode, and the anodization is performed by an electrochemical workstation in constant pressure mode, wherein the voltage range is 50V, anodized The time is 0.5h, the electrode spacing is 8cm.

[0081] (4) The titanium-based implantation body having a titanium dioxide nanotube structure after the anodized surface was rinsed with deionized water, and dried at 60 ° C.

[0082] (5) Dissolve dicamine in Tris / HCl buffer ...

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Abstract

The invention discloses a pH-responsive in-situ controlled-release titanium-based implant, a preparation method and application thereof. In the present invention, titanium-based implants are constructed on the surface of titanium-based implants through anodic oxidation to construct titanium dioxide nanotube structures, and then dopamine is used to introduce amino reaction sites on the top of titanium dioxide nanotubes, and then PMAA is grafted to it by amide reaction. Finally, the HHC36 polypeptide with antibacterial properties was loaded to obtain a pH-responsive in situ controlled-release titanium-based implant. The pH-responsive in-situ controlled-release titanium-based implant of the present invention can respond to the pH changes of the surrounding solution, regulate the release rate of antibacterial polypeptides, and has excellent antibacterial performance. In the 4th cycle sterilization experiment, it is effective against Escherichia coli and Pseudomonas aeruginosa. , Staphylococcus aureus and methicillin-resistant Staphylococcus aureus still have a bactericidal rate of more than 99%. The pH-responsive in-situ controlled-release titanium-based implant of the present invention aims at the difficult problem of bacterial infection of clinical titanium-based implants, and can reduce the risk of bacterial infection.

Description

Technical field [0001] The present invention relates to the field of medical technology, and more particularly to a pH response type in situ controlled release titanium-based implant and a preparation method thereof. Background technique [0002] Orthopedic implantation materials are one of the largest high-end medical devices, accounting for greater than 37% of the market, of which titanium-based implants are widely used in treatment due to accidents due to accidents due to accidents due to accidents, stocks. Bone necrosis, bone tumor, etc., bone defective disease, becoming one of the most commonly used orthopedic implant materials. However, the open environment and damaged immune system of bone deficiency pathogenesis makes the risks of the titanium-based implant in the application process, and the infection rate of clinical statistics is as high as 4%. At present, the preoperative preoperative method of surgery is low, it is difficult to effectively prevention and solve, and t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/30A61L27/06A61L27/50A61L27/54
CPCA61L27/06A61L27/306A61L27/34A61L27/50A61L27/54A61L2300/252A61L2300/404A61L2300/412A61L2300/606A61L2400/12A61L2400/18A61L2420/02A61L2420/04A61L2430/02C08L33/02C08L89/00
Inventor 王迎军陈军建王琳
Owner SOUTH CHINA UNIV OF TECH
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