A degradable supramolecular microgel/drug-loaded supramolecular microgel with electroactivity and its preparation method and application

A supramolecular and microgel technology, applied in the direction of organic active ingredients, medical preparations of non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of low microgel yield and lack of multi-responsive drug control. solution, poor stability, etc., to achieve the effect of simple preparation method, good potential practical value, and low cost

Inactive Publication Date: 2022-05-13
NANJING FORESTRY UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The main purpose of the present invention is to overcome the deficiencies in the prior art and provide a degradable supramolecular microgel with electroactivity and its preparation method. Another purpose of the present invention is to provide a degradable supramolecular microgel with electroactivity. Drug-loaded supramolecular microgel and preparation method thereof, to overcome the problems of low yield and poor stability of microgel prepared by existing methods and lack of multi-responsive drug controlled release

Method used

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  • A degradable supramolecular microgel/drug-loaded supramolecular microgel with electroactivity and its preparation method and application
  • A degradable supramolecular microgel/drug-loaded supramolecular microgel with electroactivity and its preparation method and application
  • A degradable supramolecular microgel/drug-loaded supramolecular microgel with electroactivity and its preparation method and application

Examples

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Embodiment 1

[0050] A method for preparing an electroactive degradable supramolecular microgel, comprising the following steps:

[0051] a: Dissolve 0.012g of chitosan, 0.584mg of sodium chloride and 1.664mg of calcium chloride in acetic acid with a volume of 1mL and a concentration of 0.1M, and stir until completely dissolved to obtain a mixed solution of chitosan and acetic acid, which is set aside;

[0052] b: adding hydroquinone, glucose and glucose oxidase with a molar ratio of 1:1:0.06 to the chitosan acetic acid mixture prepared in step a, wherein the mass ratio of chitosan and hydroquinone The ratio is 1:0.33, stir evenly, and ultrasonically disperse in a water bath for 2 minutes to obtain a uniform water phase for later use;

[0053] c: Dissolve 0.258g of Span 80 in 10ml of cyclohexane, stir until completely dissolved, and ultrasonically disperse in a water bath for 2 minutes to obtain a uniform organic phase, which is set aside;

[0054] d: Introduce argon gas into the water pha...

Embodiment 2

[0058] A method for preparing an electroactive degradable supramolecular microgel, comprising the following steps:

[0059] a: Dissolve 0.012g of chitosan, 0.584mg of sodium chloride and 1.664mg of calcium chloride in acetic acid with a volume of 1mL and a concentration of 0.1M, and stir until completely dissolved to obtain a mixed solution of chitosan and acetic acid, which is set aside;

[0060] b: adding hydroquinone, glucose and glucose oxidase with a molar ratio of 1:1:0.06 to the chitosan acetic acid mixture prepared in step a, wherein the mass ratio of chitosan and hydroquinone The ratio is 1:0.5, stir evenly, and ultrasonically disperse in a water bath for 2 minutes to obtain a uniform water phase for later use;

[0061] c: Dissolve 0.258g of Span 80 in 10ml of cyclohexane, stir until completely dissolved, and ultrasonically disperse in a water bath for 2 minutes to obtain a uniform organic phase, which is set aside;

[0062] d: Introduce argon gas into the water phas...

Embodiment 3

[0066] A method for preparing an electroactive degradable supramolecular microgel, comprising the following steps:

[0067] a: Dissolve 0.012g of chitosan, 0.584mg of sodium chloride and 1.664mg of calcium chloride in acetic acid with a volume of 1mL and a concentration of 0.1M, and stir until completely dissolved to obtain a mixed solution of chitosan and acetic acid, which is set aside;

[0068] b: adding hydroquinone, glucose and glucose oxidase with a molar ratio of 1:1:0.06 to the chitosan acetic acid mixture prepared in step a, wherein the mass ratio of chitosan and hydroquinone 1:1, stir evenly, ultrasonically disperse in a water bath for 2 minutes, obtain a uniform water phase, and set aside;

[0069] c: Dissolve 0.258g of Span 80 in 10ml of cyclohexane, stir until completely dissolved, and ultrasonically disperse in a water bath for 2 minutes to obtain a uniform organic phase, which is set aside;

[0070] d: Introduce argon gas into the water phase prepared in step b...

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Abstract

The invention provides a degradable supramolecular microgel / drug-loaded supramolecular microgel with electrical activity and its preparation method and application. The supramolecular microgel includes chitosan, hydroquinone and auxiliary materials , wherein the preparation method includes the steps of preparing an aqueous phase containing chitosan and hydroquinone and a cyclohexane organic phase containing Span 80, which are synthesized by a water-in-oil inverse microemulsion polymerization method, wherein chitosan and Hydroquinone is cross-linked through hydrogen bonding between amino groups and hydroxyl groups, and the mass ratio of chitosan and hydroquinone is 1:0.33‑3. The supramolecular microgel can efficiently load doxorubicin hydrochloride to synthesize the drug-loaded supramolecular microgel. The drug-loaded supramolecular microgel can be degraded by urea and lysozyme to realize the controlled release of the drug in a specific environment. application, providing a new approach for the development of multi-responsive drug delivery platforms.

Description

technical field [0001] The invention relates to the field of preparation of multi-responsive drug-loaded nano-platforms, in particular to a degradable drug-loaded supramolecular microgel with electroactivity and its preparation and application. Background technique [0002] In recent years, degradable and highly biocompatible natural polymer materials have attracted extensive attention in the fields of tissue engineering and drug controlled release carriers. By degrading the carrier for transporting drugs, the purpose of controlled release of drugs in the body can be achieved. At present, natural biopolymers that are widely used include cellulose, chitosan, dextran, alginate, pullulan, chondroitin sulfate, and hyaluronic acid. In order to achieve wider applications, these natural biopolymers Molecular materials are used to prepare microgel drug carriers with high water content and high hydrophilicity. The microgel drug carrier has the advantages of high biocompatibility, b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/10A61K31/704A61P35/00C08J3/075C08L5/08
CPCA61K9/06A61K47/36A61K47/10A61K31/704A61P35/00C08J3/075C08J2305/08
Inventor 李和霖曹肖兵李延军李鑫
Owner NANJING FORESTRY UNIV
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