Total-nutrient formula food for assisting in regulating intestinal immune functions

A technology of formula food and complete nutrition, which is applied in the direction of food ingredients, food ingredient functions, vitamin-containing food ingredients, etc., to achieve the effect of improving inflammatory bowel disease

Active Publication Date: 2020-02-04
JIANGNAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no complete nutritional formula food for inflammatory bowel disease in the approved food for special medical treatment in China.

Method used

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  • Total-nutrient formula food for assisting in regulating intestinal immune functions
  • Total-nutrient formula food for assisting in regulating intestinal immune functions
  • Total-nutrient formula food for assisting in regulating intestinal immune functions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1: Design of nutritional formula containing mixed protein

[0049] Prepare nutritional formula food according to the following formula, each 100g contains: carbohydrate (maltodextrin) 60g, protein 18g, fat 12g, dietary fiber 4g, vitamin A 669.6IU, vitamin D 3.125μg, vitamin E 0.0056IU, vitamin K1 0.024 mg, vitamin B1 1.025mg, vitamin B2 1.025mg, vitamin B6 1.25mg, vitamin B120.003mg, vitamin C 85.78mg, niacin 9.125mg, folic acid 0.12mg, calcium pantothenate 5.71mg, D-biotin 0.01mg, chloride Sodium 953.23mg, potassium citrate monohydrate 217.92mg, copper carbonate 1.388mg, magnesium oxide 247.016mg, iron citrate 43.424mg, zinc carbonate 10.304mg, manganese carbonate 3.48mg, calcium carbonate 1005.1mg, potassium dihydrogen phosphate 1466.39mg, Potassium iodate 0.089mg, sodium selenite 0.061mg, chromium potassium sulfate 0.324mg, ammonium molybdate tetrahydrate 0.094mg, choline chloride 167.56mg. Among them, the carbohydrate is maltodextrin, the protein is a mixtu...

Embodiment 2

[0051] Example 2: Potato protein group

[0052] Prepare nutritional formula food according to the following formula, each 100g contains: carbohydrate (maltodextrin) 60g, protein 18g, fat 12g, dietary fiber 4g, vitamin A 669.6IU, vitamin D 3.125μg, vitamin E 0.0056IU, vitamin K1 0.024 mg, vitamin B1 1.025mg, vitamin B2 1.025mg, vitamin B6 1.25mg, vitamin B120.003mg, vitamin C 85.78mg, niacin 9.125mg, folic acid 0.12mg, calcium pantothenate 5.71mg, D-biotin 0.01mg, chloride Sodium 953.23mg, potassium citrate monohydrate 217.92mg, copper carbonate 1.388mg, magnesium oxide 247.016mg, iron citrate 43.424mg, zinc carbonate 10.304mg, manganese carbonate 3.48mg, calcium carbonate 1005.1mg, potassium dihydrogen phosphate 1466.39mg, Potassium iodate 0.089mg, sodium selenite 0.061mg, chromium potassium sulfate 0.324mg, ammonium molybdate tetrahydrate 0.094mg, choline chloride 167.56mg.

[0053] Among them, the protein is potato protein; the carbohydrate is maltodextrin; the mass ratio o...

Embodiment 3

[0055] Example 3 Inflammatory Bowel Disease Whole Nutrition Formula Food Inhibits Colon Shortening in Mice with Enteritis

[0056] 40 healthy male C57BL / 6 mice of SPF grade 18-20g in 6-8 weeks were randomly divided into 4 groups: blank group (feeding basal feed), model group (feeding basal feed), mixed protein group (feeding the basal feed of Example 1) Nutritional formula food), potato protein group (feeding the nutritional formula food of embodiment 2). Ten animals in each group were raised in the Experimental Animal Center of Jiangnan University, with a constant temperature of 21-26°C, humidity of 40-70%, noise less than or equal to 60dB, and animal illumination of 15-20LX. All animal experimental procedures were reviewed and approved by the Animal Welfare and Ethics Management Committee of Jiangnan University.

[0057] From the 1st day to the 7th day of the experiment, 3.5% DSS was added to the drinking water of the mice to induce acute colitis, and they drank 3 cycles (7...

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PUM

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Abstract

The invention discloses a total-nutrient formula food for assisting in regulating intestinal immune functions, and belongs to the field of formula foods for special medical purposes. The invention finds that the full-nutrition formula food for inflammatory bowel diseases has the effects of regulating immunity to improve inflammatory bowel diseases, and the effects are specifically shown as follows: (1) inhibiting colonic shortening of enteritis mice; (2) reducing the activity of MPO (myeloperoxidase); (3) inhibiting the expression of proinflammatory factors IL-6 and TNF-alpha; and (4) inhibiting the expression of a proinflammatory factor IL-17. Therefore, the formula food disclosed by the invention has a huge application prospect in clinical application.

Description

technical field [0001] The invention relates to a full nutritional formula food for auxiliary regulation of intestinal immune function, which belongs to the field of formula food for special medical purposes. Background technique [0002] Inflammatory bowel disease, referred to as IBD, is a special chronic intestinal inflammatory disease. It mainly includes Crohn's disease (Crohn's disease, CD) and ulcerative colitis (Ulcerative Colitis, UC). The etiology and pathogenesis of inflammatory bowel disease have not been fully clarified, and it is currently believed to be caused by the interaction of multiple factors, mainly including genetic, infection, environment, immune and other factors. [0003] Clinical manifestations: (1) Digestive system manifestations: mainly include abdominal pain, diarrhea, bloody stool, abdominal mass, fistula formation, perianal lesions, etc. (2) A variety of off-site manifestations: including nausea, vomiting, loss of appetite, etc. (3) Systemic ...

Claims

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Application Information

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IPC IPC(8): A23L33/00A23L33/125A23L33/19A23L33/185A23L33/115A23L33/21A23L33/155A23L33/15A23L33/16
CPCA23L33/40A23L33/125A23L33/19A23L33/185A23L33/115A23L33/21A23L33/155A23L33/15A23L33/16A23V2002/00A23V2200/32A23V2200/3202A23V2250/1944A23V2250/5114A23V2250/702A23V2250/71A23V2250/712A23V2250/714A23V2250/7042A23V2250/7044A23V2250/7052A23V2250/706A23V2250/708A23V2250/7046A23V2250/7056A23V2250/705A23V2250/304A23V2250/16A23V2250/1614A23V2250/1578A23V2250/161A23V2250/1582A23V2250/1618A23V2250/1592A23V2250/1642A23V2250/1626A23V2250/1612A23V2250/1588A23V2250/1598A23V2250/1586A23V2250/1608A23V2250/5062A23V2250/54252A23V2250/54246A23V2250/548
Inventor 陆文伟陈卫钱成翟齐啸刘小鸣赵建新杭锋张灏
Owner JIANGNAN UNIV
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