AIE composite electrostatic spinning fibrous membrane and preparation method and application thereof

A technology of electrospinning and electrospinning solution, which is applied in the field of AIE composite electrospinning fiber membrane and its preparation, can solve the problem of antibacterial particle stability, toxicity, in vivo drug metabolism mechanism is not completely clear, antibacterial polymer has strong toxic and side effects, It is prone to problems such as cross-resistance to achieve the effect of promoting wound healing performance, excellent antibacterial function, and accelerating wound healing

Active Publication Date: 2020-02-14
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in the existing antibacterial dressings, antibiotics and their derivatives act quickly, but cross-resistance is prone to occur; antibacterial polymers have strong side effects and poor solubility, so they cannot be directly used for the treatment of infectious diseases; nanosilver, etc. The stability, toxicity and in vivo drug metabolism mechanism of antibacterial granules have not been fully clarified, and further research is needed

Method used

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  • AIE composite electrostatic spinning fibrous membrane and preparation method and application thereof
  • AIE composite electrostatic spinning fibrous membrane and preparation method and application thereof
  • AIE composite electrostatic spinning fibrous membrane and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0059] This embodiment provides an AIE composite electrospun fiber membrane, the specific preparation method is as follows:

[0060] (1) Add 20 mg of 1,1,2,2-tetra-[4-carboxy-(1,1-biphenyl)]ethylene particles into 7 mL of N,N-dimethylformamide, sonicate for 10 minutes to make the AIE particles Dissolve completely to obtain an AIE solution with an AIE molecular concentration of 2.86 mg / mL, and store the AIE solution in the dark;

[0061] (2) Dissolve 2g of PCL in 7mL of tetrahydrofuran, stir magnetically at room temperature for 3h until completely dissolved, and obtain the electrospinning precursor;

[0062] (3) Add the AIE solution obtained in step (1) to the electrospinning precursor solution obtained in step (2), and stir for 2 hours in the dark to dissolve it completely, and then stand for 0.5 hours to obtain a uniform and stable electrospinning solution. Silk liquid, the mass percentage of PCL in the electrospinning liquid is 13%;

[0063] (4) Electrospinning the electro...

Embodiment 2

[0065] This embodiment provides an AIE composite electrospun fiber membrane, the specific preparation method is as follows:

[0066] (1) Add 50mg of 1,1,2,2-tetrakis-[4-carboxy-(1,1-biphenyl)]ethylene particles to 2g of N,N-dimethylformamide, and sonicate for 10min to make the AIE particles Completely dissolve to obtain an AIE solution with an AIE molecular concentration of 23.8 mg / mL, and store the AIE solution in the dark;

[0067] (2) Mix 1 g of PLGA with 1 g of N,N-dimethylformamide and 1 g of acetone, and stir magnetically at room temperature for 3 hours until completely dissolved to obtain an electrospinning precursor;

[0068] (3) Add the AIE solution obtained in step (1) to the electrospinning precursor solution obtained in step (2), and stir for 2 hours in the dark to dissolve it completely, and then stand for 0.5 hours to obtain a uniform and stable electrospinning solution. Silk liquid, the mass percentage of PLGA in the electrospinning liquid is 20%;

[0069] (4)...

Embodiment 3

[0071] This embodiment provides an AIE composite electrospun fiber membrane, the specific preparation method is as follows:

[0072] (1) 5 mg of tetraphenylethylene particles were added to 10 mL of dimethyl sulfoxide solvent, and the tetraphenylethylene was completely dissolved by ultrasonication for 10 minutes to obtain an AIE solution with an AIE molecular concentration of 0.5 mg / mL, which was stored in the dark;

[0073] (2) Dissolve 2 g of PLA in 5 mL of dimethyl sulfoxide, stir magnetically at room temperature for 3 h until completely dissolved, and obtain an electrospinning precursor;

[0074] (3) Add the AIE solution obtained in step (1) to the electrospinning precursor solution obtained in step (2), and stir overnight in the dark to dissolve it completely, and then stand for 0.5h to obtain a uniform and stable electrospinning solution. Silk liquid, the mass percentage of PLA in the electrospinning liquid is 11%;

[0075](4) Electrospinning the electrospinning solution...

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Abstract

The invention provides an AIE composite electrostatic spinning fibrous membrane and a preparation method and application thereof. The AIE composite electrostatic spinning fibrous membrane is a nanofiber membrane formed from a biocompatibility polymer and an AIE molecule, can slowly release antibacterial activity component AIE molecules in the using process, can effectively restrain and kill bacteria, is free from any side effect on generation of normal cells, can promote adhesion, growth and proliferation of the cells, has favorable bacteria resistance and air permeability, can be completely jointed to the surface of wounds to maintain stable physiological environment, and can increase the healing speed. The AIE composite electrostatic spinning fibrous membrane is prepared by an electrostatic spinning technique, is simple in preparation method, low in cost, and suitable for large-scale industrial production, and has important application value in the respects for treating chronic wounds of wounds or burns and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an AIE composite electrospinning fiber membrane and its preparation method and application. Background technique [0002] Chronic wounds such as burns and trauma are highly susceptible to bacterial infection, which can lead to infection-related complications such as sepsis and acute renal failure. Especially after the emergence of super-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA), wound infection has become an almost unavoidable clinical problem. According to the statistics of the World Health Organization, more than 25 million people around the world suffer from traumatic infections every year, because the treatment costs for wound infections are more than tens of billions of dollars. Wound infections have become a major problem that threatens human health in the future. question. Not only that, with the abuse of antib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/20A61L15/26A61L15/28A61L15/42A61L15/44A61L15/46D01D5/00
CPCA61L15/20A61L15/26A61L15/28A61L15/42A61L15/44A61L15/46D01D5/003D01D5/0092D01D5/0069A61L2300/404A61L2300/412A61L2300/602A61L2300/216A61L2400/12C08L67/04C08L5/04C08L5/08
Inventor 蒋兴宇董瑞华
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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