Controllably degradable high-strength magnesium-based composite scaffold coating and preparation method thereof

A technology for composite stents and magnesium alloy stents, which is applied in the field of controllable degradation of high-strength magnesium-based composite stent coatings and its preparation, and can solve problems such as inability to provide stable support, decreased structural and performance stability, and failure of implanted stents , to achieve the effect of good cytocompatibility and blood compatibility, good hydrophilicity and good corrosion resistance

Active Publication Date: 2020-09-01
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bio-magnesium alloys are ideal for vascular stent materials due to their good mechanical properties, biocompatibility and complete degradability. However, magnesium and its alloys degrade too quickly in the physiological environment of the human body, and too fast degradation will lead to implant failure. The premature failure of implanted stents leads to a sharp decline in the stability of its structure and performance, and it cannot provide stable support in the process of vascular tissue repair and reconstruction in lesion parts, which largely limits its clinical application.

Method used

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  • Controllably degradable high-strength magnesium-based composite scaffold coating and preparation method thereof
  • Controllably degradable high-strength magnesium-based composite scaffold coating and preparation method thereof
  • Controllably degradable high-strength magnesium-based composite scaffold coating and preparation method thereof

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Effect test

Embodiment 1

[0033] The invention provides a method for preparing a controllable degradation high-strength magnesium-based composite stent coating, which comprises the following steps:

[0034] (1) Prefabrication of degradable magnesium alloy stent matrix: the magnesium alloy microtubes were laser cut into vascular stents, and the vascular stents were electrochemically polished in a perchloric acid alcohol solution with a concentration of 4.25% by mass; after polishing, they were treated with NaOH, Na 2 CO 3 、C 12 H 25 SO 4 Sonochemical degreasing was carried out in Na and OP-10 strong alkaline mixed solution for 3min at 60°C; in 85% H 3 PO4 and NH 3 Remove the surface oxide layer in the mixed solution of HF to obtain a passivated surface with stable potential;

[0035] (2) Treatment of the degradable magnesium alloy stent matrix: the degradable magnesium alloy stent matrix treated in step (1) was placed in Na 4 P 2O 7 10H 2 O, ZnSO4 7H 2 O solution system, then add the corrosio...

Embodiment 2

[0041] The experimental conditions and operation process of steps (1) and (2) in this example are the same as those in Example 1, and the current density of single-pulse electrodeposition in step (3) is changed to 7A / dm 2 , the specific implementation steps are in the NaOH, ZnO solution system, adding KNaC 4 H 4 O 6 ·4H 2 O was used as impurity remover, pure zinc plate was used as anode, magnesium alloy substrate was used as cathode, 260-type platinum electrode was used as auxiliary electrode, and protective zinc layer was prepared in single pulse mode, pulse frequency was 1000HZ, duty ratio was 10%, deposition temperature The temperature was 55°C, and the deposition time was 20 min. After the preparation was completed, it was rinsed with deionized water for 1 min, and dried with cold air at 25°C. Its AFM test such as figure 1 As shown in (a), the coating grains are fine and the roughness value Ra is 38.5nm; figure 2 As shown in (b), the wetting angle of the water contac...

Embodiment 3

[0043] The experimental conditions and operation process of steps (1) and (2) in this example are the same as those in Example 1, and the single-pulse electrodeposition in step (3) is changed to DC electrodeposition mode. The specific implementation steps are in the NaOH and ZnO solution system, Add KNaC 4 H 4 O 6 ·4H 2 O is used as impurity remover, pure zinc plate is used as anode, magnesium alloy substrate is used as cathode, 260-type platinum electrode is used as auxiliary electrode, and the protective zinc layer is prepared in DC mode. The deposition temperature is 55℃ and the current density is 3A / dm 2 , the deposition time is 20min, after the preparation is completed, rinse with deionized water for 1min to remove the residual solution on the surface, and dry it with cold air at 25°C.

[0044] After the preparation is completed according to the described steps, it can be observed by scanning electron microscope, such as Image 6 As shown in (a), the zinc layer on the...

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Abstract

The invention provides a controllably degradable high-strength magnesium-based composite scaffold coating and a preparation method thereof. The controllably degradable high-strength magnesium-based composite scaffold coating comprises a degradable magnesium alloy scaffold matrix, wherein the outer layer of the degradable magnesium alloy scaffold matrix is a high-strength zinc protective coating with biocompatibility; the average thickness of the high-strength zinc protective coating ranges from 5 to 40 [mu]m, the surface roughness Ra is smaller than 40 nm, and the water contact angle is smaller than 50 degrees. The specific preparation method comprises the steps that firstly, a laser cutting scaffold is subjected to an electrolytic polishing treatment, then a pretreated zinc layer is prepared, and finally the high-strength protective zinc layer is prepared through an electro-deposition process. The zinc protective coating prepared through the method is fine in tissue structure, uniform, compact and well combined with a matrix, and the mechanical strength and corrosion resistance of the magnesium alloy scaffold can be remarkably improved. The high-strength zinc protective coating shows good hydrophilicity and is very beneficial to improving the cell compatibility and the blood compatibility of a magnesium alloy intravascular scaffold.

Description

technical field [0001] The invention belongs to the technical field of magnesium alloy surface treatment, and in particular relates to a controllable degradable high-strength magnesium-based composite bracket coating and a preparation method thereof. Background technique [0002] Coronary artery stenting has become the most important means of interventional treatment for coronary heart disease today. The new generation of biodegradable stents is favored by people because it can be degraded and absorbed by the human body, and can avoid chronic complications caused by non-degradable stents. damage caused, while facilitating secondary implantation. Therefore, degradable stents become an ideal substitute for permanent stents, and the research on bioabsorbable stents has broad medical application prospects. Bio-magnesium alloys are ideal for vascular stent materials due to their good mechanical properties, biocompatibility and complete degradability. However, magnesium and its a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L31/08A61L31/14C25D5/42C25D7/00C25D3/22
CPCA61L31/022A61L31/088A61L31/14C25D5/42C25D7/00C25D3/22A61L2400/12
Inventor 朱世杰杨会玲石梦佳关绍康王利国奚廷斐王俊
Owner ZHENGZHOU UNIV
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