Absorbable barrier film and preparation method thereof

A technology of barrier membrane and collagen membrane, applied in the fields of medical science, prosthesis, tissue regeneration, etc., can solve the problems of unsatisfactory bone repair effect, insufficient vertical bone augmentation, poor mechanical properties, etc., which is conducive to the growth of bone regeneration cells. good bone repair effect and good mechanical properties

Active Publication Date: 2020-10-30
SHENZHEN LANDO BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the absorbable barrier film eliminates the defects of the non-absorbable film, it also shows its own inherent shortcomings, that is, its mechanical properties are poor, and it is easy to collapse during use, resulting in insufficient vertical bone augmentation and unsatisfactory bone repair effect

Method used

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  • Absorbable barrier film and preparation method thereof
  • Absorbable barrier film and preparation method thereof
  • Absorbable barrier film and preparation method thereof

Examples

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preparation example Construction

[0057] At this time, the preparation method of the second collagen film 230 includes the following steps: decellularizing, degreasing and dehydrating the animal tissue to obtain collagen; pulverizing the collagen to obtain collagen powder; dispersing the collagen powder in water to obtain Dispersion liquid; heating the dispersion liquid at 40°C to 50°C to obtain collagen fiber slurry; coating the collagen fiber slurry on the modified layer 240 of the magnesium alloy layer 220, and drying to obtain a porous second Collagen Membrane 230. At this time, the second communication hole 232 extends from a side of the second collagen film 230 away from the magnesium alloy layer 220 to a side close to the magnesium alloy layer 220 . In order to reduce the degradation rate of the second collagen film 230 , after coating the collagen fiber slurry on the modified layer 240 of the magnesium alloy layer 220 , the drying method is dehydrogenation heat treatment.

[0058] In this embodiment, ...

Embodiment 1

[0087] The preparation process of the absorbable barrier film of this embodiment is as follows:

[0088] (1) Prepare the magnesium alloy layer: punch holes on the magnesium alloy sheet to form the first connected hole on the magnesium alloy sheet to obtain the magnesium alloy layer, wherein the aperture of the first connected hole is 0.8 millimeters, and the thickness of the magnesium alloy layer is 0.4 mm. mm, the elemental composition of the magnesium alloy layer is magnesium, aluminum, manganese and copper.

[0089] (2) Coating a modified product on the surface of the magnesium alloy layer, the modified product being chitosan.

[0090] (3) Wash the animal tissue (pig's pericardium) 4 times with pure water, soak the animal tissue in a hydrogen peroxide solution with a mass percentage concentration of 3% for 1 hour, and then use a mass percentage concentration of 2% Sodium hydroxide solution soaked for 12 hours, then soaked in 1% hydrochloric acid for 6 hours, then transferr...

Embodiment 2

[0097] The preparation process of the absorbable barrier film of this embodiment is as follows:

[0098] (1) Prepare the magnesium alloy layer: punch holes on the magnesium alloy sheet to form the first connected hole on the magnesium alloy sheet to obtain the magnesium alloy layer. The aperture of the first connected hole is 0.5 mm, and the thickness of the magnesium alloy layer is 0.1 mm. The constituent elements of the magnesium alloy layer are magnesium, calcium, aluminum, silver, copper and manganese.

[0099] (2) Coating a modified product on the surface of the magnesium alloy layer, the modified product being gelatin.

[0100](3) Wash the animal tissue (cow's pleura) 3 times with pure water, soak the animal tissue in 0.1% peracetic acid solution by mass percentage for 1 hour, and then use 4% hydrogen Soak in potassium oxide solution for 1 hour, then immerse in 0.05% acetic acid solution for 12 hours, then transfer the animal tissue to 0.05% pepsin solution for 48 hours...

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Abstract

The invention relates to an absorbable barrier film and a preparation method thereof. The absorbable barrier film comprises a first collagen membrane, a magnesium alloy layer and a second collagen membrane, wherein the first collagen membrane is provided with a first compact layer and a porous first loose layer formed on the first compact layer; the magnesium alloy layer is arranged on the first loose layer and provided with two opposite surfaces; one surface of the magnesium alloy layer is arranged towards the first loose layer; the magnesium alloy layer is provided with a first communicatinghole penetrating through the two surfaces; the second collagen film is arranged on the other surface of the magnesium alloy layer and is provided with a second communicating hole; and the second communicating hole extends from the side, away from the magnesium alloy layer, of the second collagen film to the side, close to the magnesium alloy layer, of the second collagen film. The absorbable barrier film is good in mechanical properties and good in bone repair effect.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to an absorbable barrier film and a preparation method thereof. Background technique [0002] Guided bone regeneration (GBR) is an important clinical technique for obtaining sufficient bone mass in dental implants. GBR is to place a membrane material between the bone defect area and soft tissue as a physical barrier to create a barrier for bone tissue regeneration. The relatively closed space prevents the fast-migrating epithelial fibroblasts from growing into the bone defect to interfere with bone formation, and allows the slow-migrating osteoblasts to preferentially enter the bone defect. The barrier membrane is the key factor for the success of GBR technology. An ideal GBR membrane should have the following properties: (1) good biocompatibility, (2) sufficient space maintenance capacity, (3) able to block epithelial cells and be selectively permeable. (4) good host tissue int...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/04A61L27/24A61L27/56A61L27/58A61L27/50
CPCA61L27/24A61L27/047A61L27/58A61L27/56A61L27/50A61L2430/02
Inventor 康文亭李丽花钟梅玲朱勇军佘振定谭荣伟
Owner SHENZHEN LANDO BIOMATERIALS
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