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Plant selective antibacterial composition and application thereof

A composition and selective technology, applied in the direction of plant/algae/fungus/moss components, plant raw materials, antibacterial drugs, etc., can solve the problems that antibiotics are not easy to degrade quickly, hidden safety hazards, and have no antibacterial specificity

Pending Publication Date: 2020-12-04
SUZHOU SYLVAN NATURAL PROD R&D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And it is not easy to be rapidly degraded after antibiotic residues
For chemical preservatives, such as quaternary ammonium salts, ethanol, triclosan, etc., it is difficult to be decomposed by the human body, and they may have potential toxic and side effects after accumulating to a certain amount, so there are potential safety hazards, and there may also be risks in use. Sensory discomfort and irritation
These antibacterial agents are all broad-spectrum antibacterial agents, and have no targeted antibacterial specificity

Method used

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  • Plant selective antibacterial composition and application thereof
  • Plant selective antibacterial composition and application thereof
  • Plant selective antibacterial composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The preparation of embodiment 1 plant antibacterial composition:

[0049] Source of material:

[0050] Coptis chinensis, Cortex Phellodendron, Radix Paeoniae Rubra, Radix Cortex Radix, Fangfeng (Bozhou Lijian Pharmaceutical Co., Ltd. complies with Pharmacopoeia standards)

[0051] Ethanol (Suzhou Lihua Wine Co., Ltd., food grade)

[0052] 2. Adopted the following formula:

[0053] Formula 1: Coptidis 9kg, Phellodendron 9kg, Radix Paeoniae Rubra 9kg, Fresh Cortex 12kg, extracted by percolation with 70% ethanol for 24 hours, concentrated under reduced pressure with 0.6g of crude drug / ml in water, and left to stand for 3-6 days to take the supernatant for later use.

[0054] Windproof 9kg, water distilled for 10 hours, get the volatile oil distillate for subsequent use.

[0055] The above extracts are fed in a weight ratio of 0.3g crude drug / ml, mixed, added with conventional auxiliary materials for lotion, adjusted to pH 5-6, filtered, filled, and obtained.

[0056] F...

Embodiment 2

[0065] The quality detection of embodiment 2 plant antibacterial compositions:

[0066] 1. Test method:

[0067] 1.1 pH: Measure the 10% aqueous solution of the sample with an acidity meter.

[0068] 1.2 Determination of paeoniflorin content:

[0069] Determination is carried out by HPLC method, which has many kinds of literature reports and can be optional. In this paper, the mobile phase was methanol-water-phosphoric acid (28:72:0.1), the flow rate was 1.0ml / min, the detection wavelength was 230nm, and the column temperature was 25°C.

[0070] 1.3 Determination of coptisine content:

[0071] Determination is carried out by HPLC method, which has many kinds of literature reports and can be optional. In this paper, the mobile phase is acetonitrile-water-triethylamine-phosphoric acid (25:75:0.5:0.33), the flow rate is 1.0ml / min, the detection wavelength is 345nm, and the column temperature is 25°C.

[0072] 1.4 Determination of berberine content:

[0073] Determination is...

Embodiment 3

[0088] The bacteriostasis performance measurement of embodiment 3 plant antibacterial lotions

[0089] 1.1 Experimental materials and instruments

[0090] 1.1.1 Drugs and reagents

[0091] (1) The bacteriostatic composition preparation of Formula 1 in Example 1, with a content of 0.3 g crude drug / ml, provided by Suzhou Siyuan Natural Products Research and Development Co., Ltd.

[0092] (2) Preparation blank: content 0g crude drug / ml, provided by Suzhou Siyuan Natural Products Research and Development Co., Ltd.

[0093] (3) Compound flavescens lotion: 150ml / bottle, Zhejiang Zhongfa Pharmaceutical Co., Ltd.

[0094] (4) Penicillin sodium for injection: 800,000 U / bottle, Shandong Lukang Pharmaceutical Co., Ltd.

[0095] (5) Nystatin tablets: 500,000 units / tablet, Zhejiang Zhenyuan Pharmaceutical Co., Ltd.

[0096] (6) Sodium chloride: Shanghai Jiuyi Chemical Reagent Co., Ltd.

[0097] (7) Nutrient Broth Medium: Microbiological Reagent Factory of Jiangsu Provincial Center for...

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PUM

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Abstract

The invention discloses a plant selective antibacterial composition. The plant selective antibacterial compositioncontains active ingredients, and the active ingredients are composed of rhizoma coptidis, cortex phellodendri, radix paeoniae rubra, cortex dictamni and radix saposhnikoviae according to the weight ratio of 1: (0.5-2): (0.5-2): (0.5-3): (0.5-2), and a pharmaceutically acceptable carrier. The invention also discloses an application and a quality standard of the compound in preparation of a selective bacteriostatic agent.

Description

technical field [0001] The invention relates to the field of antibacterial disinfectant, in particular to a plant antibacterial agent selectively resisting bacterial infection. Background technique [0002] Abnormal growth of bacteria can cause disease and require the use of antibacterial agents. Commonly used antibacterial agents include synthetic antibiotics, fungicides, preservatives, natural antibacterial agents, and traditional Chinese medicines. Although people are constantly pursuing the broad-spectrum and potent antibacterial agents, not all bacteria need to be inhibited. From the perspective of human health, bacteria, probiotics and pathogenic bacteria, especially in the skin, mucous membranes, and intestinal tract, are beneficial to the human body. Only when the pathogenic bacteria proliferate in large numbers, the proportion of probiotics and pathogenic bacteria is out of balance, and the micro-ecological protection barrier of the body is damaged, will lead to di...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61P31/04A61P31/10
CPCA61K36/238A61K36/65A61K36/71A61K36/718A61K36/75A61K36/756A61K2236/331A61K2236/333A61K2236/39A61P31/04A61P31/10A61K2300/00A61P31/02Y02A50/30
Inventor 徐丽华
Owner SUZHOU SYLVAN NATURAL PROD R&D CO LTD
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