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Zwitterionic polymer and heparin composite coating as well as preparation method and application thereof

A zwitterion, composite coating technology, applied in coatings, drug delivery, pharmaceutical formulations, etc., can solve problems such as reducing the hydrophobicity of membrane pores and increasing the risk of blood leakage through the micropores of the membrane wall.

Active Publication Date: 2021-02-05
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When this coating modifies the surface of the hollow fiber membrane, the organic solvent solution will penetrate into the membrane pores of the hollow fiber membrane to form a PC polymer coating to reduce the hydrophobicity of the membrane pores, thereby increasing the blood oxygenation process. Risk of leakage through micropores in the membrane wall

Method used

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  • Zwitterionic polymer and heparin composite coating as well as preparation method and application thereof
  • Zwitterionic polymer and heparin composite coating as well as preparation method and application thereof
  • Zwitterionic polymer and heparin composite coating as well as preparation method and application thereof

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preparation example Construction

[0046] The preparation method of the zwitterionic polymer and heparin composite coating of the present invention comprises the following steps:

[0047] Step 1: Provide a mediator layer, mix the biomimetic universal adhesive material A and the crosslinking agent B according to the mass ratio of A:B=10:1~3:2 to prepare an A+B aqueous solution, and immerse the material to be modified in the aqueous solution , get the mediation layer.

[0048] The main component of the biomimetic universal adhesive material A in the mediation layer is dopamine hydrochloride or dopa hydrochloride containing catechol groups, which are biomimetic adhesion molecules that are easily oxidized and polymerized. Biomimetic adhesion molecules will be oxidatively polymerized by dissolved oxygen or added oxidants in aqueous solution, and automatically form a coating that adheres to the surface of the material and can be modified again. In the aqueous solution, it is difficult for the adhesion molecules to e...

Embodiment 1

[0063] Step 1, dissolve dopamine hydrochloride and polyethyleneimine (PEI) in a mixed solvent of absolute ethanol: pH8.5 Tris-HCl buffer solution = 1:1 (volume ratio of 10:1) according to the mass ratio , prepared as a solution containing dopamine hydrochloride 2mg / mL, PEI 0.2mg / mL, immersed in different material sheets in Table 1 and reacting at 90rpm for 6h based on a 30°C water-bath shaker. Take it out, rinse it with deionized water, dry it with cold air, and measure its contact angle. The significant changes in the water contact angle of the surface before and after coating in Table 1 indicate that the mediation layer was successfully constructed.

[0064] Table 1. Variations of water contact angles on the surface of substrates of different materials before and after coating with a dielectric layer.

[0065] material type Water contact angle before coating (°) Water contact angle after coating (°) glass sheet 30.3±2.0 33.5±1.3 polycarbonate sheet...

Embodiment 2

[0069]Step 1, mix and prepare the bionic universal adhesive material A and crosslinking agent B aqueous solution shown in Table 2 according to the mass ratio of 10:1 to 3:2, soak and wash the PVC catheter with absolute ethanol, and then immerse it in the water solution shown in Table 2 respectively. In the solution, react at 30°C for 4h to build a mediator coating. After the catheter was taken out and rinsed with a large amount of deionized water, the water contact angle was measured after drying with a hair dryer at room temperature. Compared with the water contact angle of the PVC pipe department before modification, the significantly reduced water contact angle indicated that PVC / PDA, PVC / PDA-PEI, PVC / PDA-PLys, PVC / PDA-APTMS, PVC / PDopa-PEI and PVC / PDA PDopa-PLys-mediated coating construction was successful.

[0070] Table 2. The water contact angle and solution composition of the mediation coating constructed by dip coating on the surface of PVC catheter.

[0071]

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Abstract

The invention discloses a zwitterionic polymer and heparin composite coating and a preparation method and application thereof. The zwitterionic polymer and heparin composite coating comprises a mediation layer, a zwitterionic polymer layer and a heparin anticoagulation layer. The coating comprises the following construction steps: immersing an object to be coated and modified into an aqueous solution of bionic universal adhesive molecules to form the mediation layer with surface amino / hydroxyl on the surface of the object; then performing immersing into the zwitterionic polymer solution to form a multiple amido bond anchoring coating; and finally, performing amidation reaction with residual amino on the surface in a heparin solution for grafting heparin. The bionic adhesion mediation layerforms a cross-linked structure on the surface of the bionic adhesion mediation layer, so that the stability and the blood compatibility of the composite coating are remarkably improved. Heparin molecules are anchored onto the surface of a zwitterionic polymer anchored by multiple amido bonds through covalent bonds, so that excellent anticoagulant activity can be obtained. The method is suitable for directly constructing coatings on the surfaces of various materials and various shapes of devices, and long-term stable anticoagulation and biological pollution resistance can be obtained.

Description

technical field [0001] The invention belongs to the field of anti-coagulation, anti-biological pollution materials and surface modification of medical devices, and relates to an anti-coagulation and anti-biological pollution blood compatibility coating, which has the functions of anti-thrombosis and anti-biological component adhesion pollution Material coatings and methods for their preparation. Background technique [0002] The hemodialysis system, extracorporeal membrane oxygenation system, artificial blood vessels and various catheters composed of various polymer materials not only save lives, but also cause harm to blood and human health. After these materials come into contact with blood, the proteins in the blood are quickly adsorbed, denatured and activated on the surface, inducing platelet adhesion, aggregation and activation, triggering the endogenous coagulation cascade reaction to form thrombus, leading to treatment failure and endangering health. In addition, du...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/14A61L31/16A61L33/10A61L33/00A61L33/06
CPCA61L31/10A61L31/14A61L31/16A61L33/08A61L33/0011A61L33/0029A61L33/064A61L33/068A61L2300/42A61L2300/236A61L2400/18A61L2420/02A61L2420/08C08L33/14C08L5/10C08L79/02
Inventor 宫永宽李荣白云杰马瑶
Owner NORTHWEST UNIV(CN)
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