Preparation method and application of PEGylated MSNs nanoparticle and mesoporous silica modified sustained-release hydrogel composite material

Abstract

The invention relates to a preparation method and application of a PEGylated MSNs nanoparticle and mesoporous silica modified sustained-release hydrogel composite material. Octyl modified hydrophobicMSNs and an amphiphilic block copolymer PF127 are used, and through the hydrophobic effect between PPO blocks of the PF127 and octyls on the surfaces of the MSNs, the hydrophobic MSNs are easily transferred to the surfaces of the MSNs through self-assembly of PF127 molecules. Besides, the hydrophobic MSNs are loaded before the capping process of the PF127, loaded and PEGylated MSNs can be simply prepared, the prepared OMSF still shows good dispersity in water and has high affinity with dental pulp stem cells, and a PF127 polymer layer around the nanoparticles achieves the effect of preventinga diffusion barrier of drug release from pores, so that the release rate of drug-loaded H2S is reduced, and the required drug concentration can be prolonged and maintained in vivo to provide more effective treatment.

Description

technical field [0001] The invention relates to the technical field of new materials, in particular to a preparation method and application of a slow-controlled release hydrogel composite material modified by PEGylated MSNs nanoparticles and mesoporous silica. Background technique [0002] The high specific surface area and pore volume, good chemical stability and easy surface functionalization of mesoporous silica nanoparticles (MSNs) make them promising as drug carriers and medical agents in biological applications. . Silica-based materials are generally recognized as biocompatible by the U.S. Food and Drug Administration (FDA). However, recent studies have demonstrated potential toxicity in vitro and in vivo when their particle size is reduced to the nanoscale. Although the toxicity of silica-based nanomaterials depends on several factors including particle size, shape, surface chemistry, and porosity, it is generally accepted that the chemical structure of the surface ...

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Problems solved by technology

However, the PEGylation process has some limitations: (1) mainly requires tedious organic synthesis and surface modification; (2) the pores of MSNs may be blocked by long PEG polymer chains, which hinders the drug loading process

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