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Glucosamine composite functional formula, tablet containing glucosamine composite functional formula and preparation method thereof

A functional and glucosamine technology, applied in the functions of food ingredients, food shaping, food ingredients containing natural extracts, etc., can solve the problem that functional ingredients cannot be well absorbed and utilized, repair and treatment effects cannot be achieved, and dosage Unreasonable and other problems, to achieve the effect of improving bioavailability, increasing nutritional and health care functions, and avoiding sticking phenomenon

Inactive Publication Date: 2021-04-30
JIANGSU ALAND NOURISHMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] As a drug, glucosamine has many disadvantages, such as glucosamine is highly hygroscopic, and its amino group is easily oxidized and discolored. Therefore, the preparation requirements of glucosamine are relatively high, such as tablets need to be coated, packed in ampoules, and capsules should The shell is sealed and requires protection from moisture and oxygen
In addition, most of the commercially available glucosamine products have less effective drug content, poor stability, and low bioavailability. At present, there are many kinds of products for osteoarthritis, bone damage or osteoporosis in the domestic and foreign markets, and the quality varies. Qi, the existing dietary supplements on the market more or less have problems such as single nutrient composition, unreasonable composition and matching ratio, or unreasonable dosage, which leads to the inability of various functional ingredients to be well absorbed in the human body And use, can not achieve the ideal repair and treatment effect

Method used

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  • Glucosamine composite functional formula, tablet containing glucosamine composite functional formula and preparation method thereof
  • Glucosamine composite functional formula, tablet containing glucosamine composite functional formula and preparation method thereof
  • Glucosamine composite functional formula, tablet containing glucosamine composite functional formula and preparation method thereof

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preparation example Construction

[0037] According to another aspect of the present invention, there is also provided a method for preparing a tablet containing the above-mentioned compound functional ingredient formula of ammonia sugar, comprising the following steps:

[0038] S1. Mix D-glucosamine hydrochloride, turmeric extract, and povidone K30 to form a mixture A, mix povidone K90 with water to prepare a slurry with a concentration of 5%, mix the mixture A into the slurry, and fully Dissolve until clear and transparent, put the obtained mixed material into a wet granulator, stir and mix to obtain the glucosamine hydrochloride turmeric extract granules;

[0039] S2. Mix the frankincense extract and calcium carbonate to obtain a mixture B, prepare a slurry with a concentration of 1% with an appropriate amount of water and hypromellose, mix the mixture B into the slurry, fully dissolve until it is clear and transparent, and obtain Put the mixed material into the wet granulator, stir and mix, and obtain the f...

Embodiment 1

[0047] The preparation of the compound functional ingredient dosage form of glucosamine comprises the following steps:

[0048] 1) Prepare glucosamine hydrochloride turmeric extract granules; mix 77.6wt% D-glucosamine hydrochloride, 20wt% turmeric extract, and 2wt% povidone K30 to obtain mixture A. Prepare 0.4wt% povidone K90 with an appropriate amount of water to make a slurry with a concentration of 5wt%, fully dissolve the mixture A into the slurry until it is clear and transparent, put the obtained mixed material into a wet granulator, stir for 10 minutes, and mix well , to obtain glucosamine hydrochloride turmeric extract granules.

[0049] 2) Wet granulation of Boswellia extract: Mix 52 parts by weight of Boswellia extract, 47 parts by weight of calcium carbonate, and 1 part by weight of hypromellose to obtain a mixture B. Prepare hypromellose with an appropriate amount of water to make a slurry with a concentration of 1 wt%, fully dissolve the mixture B until it is cle...

Embodiment 2

[0054]1) Preparation of glucosamine hydrochloride turmeric extract granules: Mix 77.6wt% D-glucosamine hydrochloride, 20wt% turmeric extract, and 2wt% povidone K30 to obtain mixture A. Prepare 0.4wt% povidone K90 with an appropriate amount of water to make a slurry with a concentration of 5wt%, fully dissolve the mixture A into the slurry until it is clear and transparent, put the obtained mixed material into a wet granulator, stir for 10 minutes, and mix well , to obtain glucosamine hydrochloride turmeric extract granules.

[0055] 2) Wet granulation of Boswellia extract: Mix 52 parts by weight of Boswellia extract, 47 parts by weight of calcium carbonate, and 1 part by weight of hypromellose to obtain a mixture B. Prepare hypromellose with an appropriate amount of water to make a slurry with a concentration of 1 wt%, fully dissolve the mixture B until it is clear and transparent, put the obtained mixture into a wet granulator, stir for 5 minutes, and mix well to obtain the f...

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Abstract

The invention discloses a glucosamine composite functional component formula, a tablet containing the glucosamine composite functional component formula and a preparation method thereof. The glucosamine composite functional component formula comprises the following components in percentage by weight: 30-65% of glucosamine hydrochloride turmeric extract particles; 5-30% of sodium chondroitin sulfate; 1-20% of frankincense extract particles; 2-20% of a horse chestnut extract; 0.2-8% of a black pepper extract; 0.5-10% of vitamin C; 8-20% of microcrystalline cellulose; 0-2% of croscarmellose sodium; 0-2.5% of silicon dioxide; 0-2.5% of polyvinylpolypyrrolidone; 0.2-2% of magnesium stearate; and 4-10% of a coating premix. According to the invention, Chinese and western medicines are adopted to form a compound, the components and contents are selected, and the direct synergistic effect of the components is utilized, so that the bioavailability is greatly enhanced, the enhancement effect in the aspects of bone mineral density and immunity is improved, and especially curcumin and piperine components are utilized to play a crucial auxiliary role in relieving inflammation.

Description

technical field [0001] The invention belongs to the technical field of food, and in particular relates to a compound functional formula of ammonia sugar, a tablet containing it and a preparation method. Background technique [0002] Osteoarthropathy, as a stubborn disease, is afflicting countless patients, and it is urgent to prevent and treat osteoarthrosis. As a dietary supplement with a wide range of sources, glucosamine and chondroitin sulfate have preventive and therapeutic effects on osteoarthritis in middle-aged and elderly people and some special populations. Glucosamine can reduce the concentration of pro-inflammatory transcription factors, enhance the toughness of specific parts of cartilage, and prevent collagen denaturation by inhibiting the activity of hydrolytic enzymes and reducing the oxidation of lipids and proteins. Glucosamine can improve the metabolic function and nutrient absorption of bone and cartilage tissue by stimulating the biochemical synthesis o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/125A23L33/10A23L33/105A23L33/15A23P10/28
CPCA23L33/125A23L33/10A23L33/105A23L33/15A23P10/28A23V2002/00A23V2200/30A23V2200/306A23V2250/2112A23V2250/21A23V2250/51084A23V2250/51088A23V2250/708
Inventor 陈洋张国栋贺庆夏旭东张兴张勇
Owner JIANGSU ALAND NOURISHMENT
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